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Select item 111132571.

Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age‐dependent fashion and induces cell senescence via GDF15

Antonio Chiariello, Luca Rossetti, Sabrina Valente, Gianandrea Pasquinelli, Manuela Sollazzo, Luisa Iommarini, Anna Maria Porcelli, Monica Tognocchi, Giuseppe Conte, Aurelia Santoro, Katarzyna M. Kwiatkowska, Paolo Garagnani, Stefano Salvioli, Maria Conte

Aging Cell. 2024 May; 23(5): e14111. Published online 2024 Apr 22. doi: 10.1111/acel.14111

PMCID:: PMC11113257

Abstract Article PDF–10M

Select item 109850022.

TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2

Jun Li, Qian Zhang, Yupeng Guan, Dingzhun Liao, Huikun Chen, Haiyun Xiong, Yiyu Sheng, Xianju Chen, Jun Pang

Cell Death Dis. 2024 Apr; 15(4): 240. Published online 2024 Apr 1. doi: 10.1038/s41419-024-06627-4

PMCID:: PMC10985002

Abstract Article PDF–8.0M

Select item 108056693.

Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2

Yonat Tzur, Katarzyna Winek, Nimrod Madrer, Serafima Dubnov, Estelle R. Bennett, David S. Greenberg, Geula Hanin, Asaad Gammal, Joseph Tam, Isaiah T. Arkin, Iddo Paldor, Hermona Soreq

Mol Metab. 2024 Jan; 79: 101856. Published online 2023 Dec 22. doi: 10.1016/j.molmet.2023.101856

PMCID:: PMC10805669

Abstract Article PDF–2.6M

Select item 107024784.

Perilipin 2–positive mononuclear phagocytes accumulate in the diabetic retina and promote PPARγ-dependent vasodegeneration

Guillaume Blot, Rémi Karadayi, Lauriane Przegralek, Thérèse-Marie Sartoris, Hugo Charles-Messance, Sébastien Augustin, Pierre Negrier, Frédéric Blond, Frida Paulina Muñiz-Ruvalcaba, David Rivera-de la Parra, Lucile Vignaud, Aude Couturier, José-Alain Sahel, Niyazi Acar, Aida Jimenez-Corona, Cécile Delarasse, Yonathan Garfias, Florian Sennlaub, Xavier Guillonneau

J Clin Invest. 2023 Oct 2; 133(19): e161348. Published online 2023 Oct 2. doi: 10.1172/JCI161348

PMCID:: PMC10702478

Abstract Article PDF–13M

Select item 102358835.

Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle

Wanni Zhao, Yansong Zhang, Siyuan Lin, Yajuan Li, Alan Jian Zhu, Hanping Shi, Min Liu

J Cachexia Sarcopenia Muscle. 2023 Jun; 14(3): 1454–1467. Published online 2023 Apr 13. doi: 10.1002/jcsm.13233

PMCID:: PMC10235883

Abstract Article PDF–8.9M

Select item 98519736.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 95617817.

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2‐Dependent Mitotic Cell Death

Marcos Rios Garcia, Bettina Meissburger, Jessica Chan, Roldan M. de Guia, Frits Mattijssen, Stephanie Roessler, Andreas L. Birkenfeld, Nathanael Raschzok, Fabien Riols, Janina Tokarz, Maude Giroud, Manuel Gil Lozano, Goetz Hartleben, Peter Nawroth, Mark Haid, Miguel López, Stephan Herzig, Mauricio Berriel Diaz

Adv Sci (Weinh) 2022 Oct; 9(29): 2104291. Published online 2022 Aug 28. doi: 10.1002/advs.202104291

PMCID:: PMC9561781

Abstract Article PDF–4.4M

Select item 93323118.

Sex-Dependent Mediation of Leptin in the Association of Perilipin Polymorphisms with BMI and Plasma Lipid Levels in Children

Claudia Vales-Villamarín, Jairo Lumpuy-Castillo, Teresa Gavela-Pérez, Olaya de Dios, Iris Pérez-Nadador, Leandro Soriano-Guillén, Carmen Garcés

Nutrients. 2022 Aug; 14(15): 3072. Published online 2022 Jul 26. doi: 10.3390/nu14153072

PMCID:: PMC9332311

Abstract Article PDF–900K

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 863973110.

Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα

Ozren Stojanović, Jordi Altirriba, Dorothée Rigo, Martina Spiljar, Emilien Evrard, Benedek Roska, Salvatore Fabbiano, Nicola Zamboni, Pierre Maechler, Françoise Rohner-Jeanrenaud, Mirko Trajkovski

Nat Commun. 2021; 12: 7031. Published online 2021 Dec 2. doi: 10.1038/s41467-021-27133-7

PMCID:: PMC8639731

Abstract Article PDF–2.6M

Select item 856440411.

Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes

Xin Tong, Roland Stein

Diabetes. 2021 Nov; 70(11): 2595–2607. Published online 2021 Aug 25. doi: 10.2337/db21-0261

PMCID:: PMC8564404

Abstract Article PDF–3.5M

Select item 826228012.

Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria

Akansha Mishra, Siming Liu, Joseph Promes, Mikako Harata, William Sivitz, Brian Fink, Gourav Bhardwaj, Brian T. O’Neill, Chen Kang, Rajan Sah, Stefan Strack, Samuel Stephens, Timothy King, Laura Jackson, Andrew S. Greenberg, Frederick Anokye-Danso, Rexford S. Ahima, James Ankrum, Yumi Imai

JCI Insight. 2021 May 10; 6(9): e144341. Published online 2021 May 10. doi: 10.1172/jci.insight.144341

PMCID:: PMC8262280

Abstract Article PDF–2.0M

Select item 818645513.

Urinary Aquaporin-1 and Perilipin-2: Can These Novel Markers Accurately Characterize Small Renal Masses and Help Guide Patient Management?

Joseph B. Song, Jeremiah J. Morrissey, Jonathan M. Mobley, Karen G. Figenshau, Joel M. Vetter, Sam B. Bhayani, Evan D. Kharasch, Robert Sherburne Figenshau

Int J Urol. Author manuscript; available in PMC 2021 Jun 8.

Published in final edited form as: Int J Urol. 2019 Feb; 26(2): 260–265. Published online 2018 Nov 22. doi: 10.1111/iju.13854

PMCID:: PMC8186455

Abstract Article PDF–343K

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810853615.

A single nucleotide polymorphism of PLIN2 is associated with nonalcoholic steatohepatitis and causes phenotypic changes in hepatocyte lipid droplets: A pilot study

Claire S. Faulkner, Collin M. White, Vijay H. Shah, Loretta L. Jophlin

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2020 May; 1865(5): 158637. Published online 2020 Jan 23. doi: 10.1016/j.bbalip.2020.158637

PMCID:: PMC8108536

Article PDF–395K

Select item 807819216.

Novel genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the Ketone metabolism pathway are associated with survival of non-small cell lung cancer

Dongfang Tang, Yu Chen Zhao, Hongliang Liu, Sheng Luo, Jeffrey M. Clarke, Carolyn Glass, Li Su, Sipeng Shen, David C. Christiani, Wen Gao, Qingyi Wei

Int J Cancer. Author manuscript; available in PMC 2021 Apr 27.

Published in final edited form as: Int J Cancer. 2020 Sep 15; 147(6): 1559–1570. Published online 2020 Mar 9. doi: 10.1002/ijc.32932

PMCID:: PMC8078192

Abstract Article PDF–991K

Select item 803488417.

Circulating perilipin 2 levels are associated with fat mass, inflammatory and metabolic markers and are higher in women than men

Maria Conte, Aurelia Santoro, Salvatore Collura, Morena Martucci, Giuseppe Battista, Alberto Bazzocchi, Cristina Morsiani, Federica Sevini, Miriam Capri, Daniela Monti, Claudio Franceschi, Stefano Salvioli

Aging (Albany NY) 2021 Mar 31; 13(6): 7931–7942. Published online 2021 Mar 17. doi: 10.18632/aging.202840

PMCID:: PMC8034884

Abstract Article PDF–519K

Select item 752544118.

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion

Hyeon Gyu Seo, Han Byeol Kim, Ji Young Yoon, Tae Hyun Kweon, Yun Soo Park, Jingu Kang, Jinwoo Jung, SeongJin Son, Eugene C. Yi, Tae Ho Lee, Won Ho Yang, Jin Won Cho

Cell Death Dis. 2020 Sep; 11(9): 815. Published online 2020 Sep 29. doi: 10.1038/s41419-020-02999-5

PMCID:: PMC7525441

Abstract Article PDF–3.7M

Select item 716998319.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 696215220.

Adipophilin and perilipin 3 positively correlate with total lipid content in human breast milk

Tereza Pavlova, Zdenek Spacil, Veronika Vidova, Filip Zlamal, Eliska Cechova, Zuzana Hodicka, Julie Bienertova-Vasku

Sci Rep. 2020; 10: 360. Published online 2020 Jan 15. doi: 10.1038/s41598-019-57241-w

PMCID:: PMC6962152

Abstract Article PDF–1.0M

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