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Select item 90163201.

A Hypoxia-Induced SCF^FBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis

Jun Zeng, Xiao-qing Xiao, Zhi-yong Zhou

Cancer Res Treat. 2022 Apr; 54(2): 525–540. Published online 2021 Jun 29. doi: 10.4143/crt.2021.373

PMCID:: PMC9016320

Abstract Article PDF–3.0M

Select item 77337862.

Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity

Qiu-Wen Wang, Si-Yao Lu, Yao-Nan Liu, Yun Chen, Hui Wei, Wei Shen, Yan-Fen Chen, Chong-Lei Fu, Ying-Han Wang, Anbang Dai, Xuan Huang, Fred H. Gage, Qi Xu, Jun Yao

Proc Natl Acad Sci U S A. 2020 Dec 8; 117(49): 31438–31447. Published online 2020 Nov 23. doi: 10.1073/pnas.2016416117

Correction in:: Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2111933118.

PMCID:: PMC7733786

Abstract Article PDF–2.5M

Select item 73720813.

Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding

Duc T. Tran, Anita Pottekat, Saiful A. Mir, Salvatore Loguercio, Insook Jang, Alexandre Rosa Campos, Kathleen M. Scully, Reyhaneh Lahmy, Ming Liu, Peter Arvan, William E. Balch, Randal J. Kaufman, Pamela Itkin-Ansari

Diabetes. 2020 Aug; 69(8): 1723–1734. Published online 2020 May 26. doi: 10.2337/db20-0245

PMCID:: PMC7372081

Abstract Article PDF–2.0M

Select item 70491554.

Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice

Wei Shen, Qiu-Wen Wang, Yao-Nan Liu, Maria C. Marchetto, Sara Linker, Si-Yao Lu, Yun Chen, Chuihong Liu, Chongye Guo, Zhikai Xing, Wei Shi, John R. Kelsoe, Martin Alda, Hongwei Wang, Yi Zhong, Sen-Fang Sui, Mei Zhao, Yiming Yang, Shuangli Mi, Liping Cao, Fred H. Gage, Jun Yao

Proc Natl Acad Sci U S A. 2020 Feb 25; 117(8): 4392–4399. Published online 2020 Feb 10. doi: 10.1073/pnas.1918165117

PMCID:: PMC7049155

Abstract Article PDF–1.2M

Select item 69420445.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 67468226.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

Select item 64288687.

Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7

Hai T. Tran, Lauren H. Anderson, Jefferson D. Knight

Biophys J. 2019 Mar 19; 116(6): 1025–1036. Published online 2019 Feb 5. doi: 10.1016/j.bpj.2019.01.035

PMCID:: PMC6428868

Abstract Article PDF–1.5M

Select item 63865888.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 63672069.

Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells

Zhenhua Fei, Wei Gao, Raoying Xie, Ganzhu Feng, Xiaolin Chen, Yiyan Jiang

Biosci Rep. 2019 Feb 28; 39(2): BSR20181298. Prepublished online 2019 Jan 15. Published online 2019 Feb 8. doi: 10.1042/BSR20181298

PMCID:: PMC6367206

Abstract Article PDF–1.1M

Select item 616668210.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 589241111.

Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses

Josef Turecek, Skyler L. Jackman, Wade G. Regehr

Nature. Author manuscript; available in PMC 2018 Apr 30.

Published in final edited form as: Nature. 2017 Nov 23; 551(7681): 503–506. Published online 2017 Oct 30. doi: 10.1038/nature24474

PMCID:: PMC5892411

Abstract Article PDF–2.8M

Select item 555766012.

Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed at Atomic Detail

Josh V. Vermaas, Emad Tajkhorshid

Biochemistry. Author manuscript; available in PMC 2017 Aug 15.

Published in final edited form as: Biochemistry. 2017 Jan 10; 56(1): 281–293. Published online 2016 Dec 20. doi: 10.1021/acs.biochem.6b00468

PMCID:: PMC5557660

Abstract Article PDF–3.7M

Select item 545599613.

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

Joseph Rosenbluh, Johnathan Mercer, Yashaswi Shrestha, Rachel Oliver, Pablo Tamayo, John G. Doench, Itay Tirosh, Federica Piccioni, Ella Hartenian, Heiko Horn, Lola Fagbami, David E. Root, Jacob Jaffe, Kasper Lage, Jesse S. Boehm, William C. Hahn

Cell Syst. Author manuscript; available in PMC 2017 Sep 28.

Published in final edited form as: Cell Syst. 2016 Sep 28; 3(3): 302–316.e4. doi: 10.1016/j.cels.2016.09.001

PMCID:: PMC5455996

Abstract Article PDF–3.1M

Select item 538463714.

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells

Subhankar Dolai, Li Xie, Dan Zhu, Tao Liang, Tairan Qin, Huanli Xie, Youhou Kang, Edwin R. Chapman, Herbert Y. Gaisano

Diabetes. 2016 Jul; 65(7): 1962–1976. Published online 2016 Apr 26. doi: 10.2337/db15-1436

PMCID:: PMC5384637

Abstract Article PDF–2.5M

Select item 510212115.

Plexin C1 deficiency permits synaptotagmin 7–mediated macrophage migration and enhances mammalian lung fibrosis

Xueyan Peng, Meagan Moore, Aditi Mathur, Yang Zhou, Huanxing Sun, Ye Gan, Jose D. Herazo-Maya, Naftali Kaminski, Xinyuan Hu, Hongyi Pan, Changwan Ryu, Awo Osafo-Addo, Robert J. Homer, Carol Feghali-Bostwick, Wassim H. Fares, Mridu Gulati, Buqu Hu, Chun-Geun Lee, Jack A. Elias, Erica L. Herzog

FASEB J. 2016 Dec; 30(12): 4056–4070. Published online 2016 Sep 8. doi: 10.1096/fj.201600373R

PMCID:: PMC5102121

Abstract Article

Select item 497239716.

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

Zhenhuan Guo, Lisa J Neilson, Hang Zhong, Paul S Murray, Megha Vaman Rao, Sara Zanivan, Ronen Zaidel-Bar

Sci Signal. Author manuscript; available in PMC 2016 Aug 3.

Published in final edited form as: Sci Signal. 2014 Dec 2; 7(354): rs7. Published online 2014 Dec 2. doi: 10.1126/scisignal.2005473

PMCID:: PMC4972397

Abstract Article PDF–3.1M

Select item 427867917.

Lateral Diffusion of Proteins on Supported Lipid Bilayers: Additive Friction of Synaptotagmin 7 C2A–C2B Tandem Domains

Joseph K. Vasquez, Kan Chantranuvatana, Daniel T. Giardina, Matthew D. Coffman, Jefferson D. Knight

Biochemistry. 2014 Dec 23; 53(50): 7904–7913. Published online 2014 Dec 1. doi: 10.1021/bi5012223

PMCID:: PMC4278679

Abstract Article PDF–4.8M

Select item 426658818.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 412386219.

Genome-Wide Association Study of Plasma N6 Polyunsaturated Fatty Acids within the CHARGE Consortium

Weihua Guan, Brian T. Steffen, Rozenn N. Lemaitre, Jason H.Y. Wu, Toshiko Tanaka, Ani Manichaikul, Millennia Foy, Stephen S. Rich, Lu Wang, Jennifer A. Nettleton, Weihong Tang, Xiangjun Gu, Stafania Bandinelli, Irena B. King, Barbara McKnight, Bruce M. Psaty, David Siscovick, Luc Djousse, Yii-Der Ida Chen, Luigi Ferrucci, Myriam Fornage, Dariush Mozafarrian, Michael Y. Tsai, Lyn M. Steffen

Circ Cardiovasc Genet. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Jun; 7(3): 321–331. Published online 2014 May 13. doi: 10.1161/CIRCGENETICS.113.000208

PMCID:: PMC4123862

Abstract Article PDF–430K

Select item 377350520.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

Simona Principe, E. Ellen Jones, Yunee Kim, Ankit Sinha, Julius O. Nyalwidhe, Jasmin Brooks, O. John Semmes, Dean A. Troyer, Raymond S. Lance, Thomas Kislinger, Richard R. Drake

Proteomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Proteomics. 2013 May; 13(0): 1667–1671. Published online 2013 Apr 23. doi: 10.1002/pmic.201200561

PMCID:: PMC3773505

Abstract Article PDF–630K

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