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Select item 112342091.

Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma

Ming-Hao Xu, Yi-Min Zheng, Bu-Gang Liang, Wen-Xin Xu, Jun Cao, Pei Wang, Zi-Ying Dong, Chen-Hao Zhou, Hui-Chuan Sun, Ning Ren, Ai-Wu Ke, Ying-Hao Shen

Int J Biol Sci. 2024; 20(9): 3269–3284. Published online 2024 Jun 3. doi: 10.7150/ijbs.96031

PMCID:: PMC11234209

Abstract Article PDF–9.9M

Select item 106618262.

A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity

Kristian Assing, Sofie E. Jørgensen, Katrine S. Sandgaard, Kerstin De Keukeleere, Marie B.-Hansen, Mikkel S. Petersen, Ulla B. Hartling, Thanis M. K.-de Vaal, Christian Nielsen, Marianne A. Jakobsen, Eleanor Watt, Stuart Adams, Qin Hao, Christina Fagerberg, Trine H. Mogensen

J Clin Immunol. 2023; 43(8): 1927–1940. Published online 2023 Aug 15. doi: 10.1007/s10875-023-01561-0

PMCID:: PMC10661826

Abstract Article PDF–4.5M

Select item 105722173.

PAK1 and Therapy Resistance in Melanoma

Julia V. Kichina, Alexei Maslov, Eugene S. Kandel

Cells. 2023 Oct; 12(19): 2373. Published online 2023 Sep 28. doi: 10.3390/cells12192373

PMCID:: PMC10572217

Abstract Article PDF–1.6M

Select item 104114774.

PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry

Chien-Feng Li, Ti-Chun Chan, Fu-Min Fang, Shih-Chen Yu, Hsuan-Ying Huang

Int J Biol Sci. 2023; 19(12): 3920–3936. Published online 2023 Jul 31. doi: 10.7150/ijbs.83467

PMCID:: PMC10411477

Abstract Article PDF–6.3M

Select item 102987845.

PAK1 copy number in breast cancer—Associations with proliferation and molecular subtypes

Anette H. Skjervold, Marit Valla, Borgny Ytterhus, Anna M. Bofin

PLoS One. 2023; 18(6): e0287608. Published online 2023 Jun 27. doi: 10.1371/journal.pone.0287608

PMCID:: PMC10298784

Abstract Article PDF–1.2M

Select item 102841176.

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry

Fenglong Jiao, Leah J. Salituro, Clinton Yu, Craig B. Gutierrez, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Anal Chem. 2023 Jan 31; 95(4): 2532–2539. Published online 2023 Jan 18. doi: 10.1021/acs.analchem.2c04986

PMCID:: PMC10284117

Abstract Article PDF–2.5M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100534038.

Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling

Tao Xu, Peng Gao, Yifan Huang, Mengyuan Wu, Jiang Yi, Zheng Zhou, Xuan Zhao, Tao Jiang, Hao Liu, Tao Qin, Zhenqi Yang, Xiaowei Wang, Tianyi Bao, Jian Chen, Shujie Zhao, Guoyong Yin

Redox Biol. 2023 Jun; 62: 102682. Published online 2023 Mar 20. doi: 10.1016/j.redox.2023.102682

PMCID:: PMC10053403

Abstract Article PDF–12M

Select item 99786359.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 980021410.

阻断PAK1激酶活性对急性巨核细胞白血病细胞分化及凋亡的影响

王淑瑾, 王春晴, 胡雪婷, 于翔茹, 付春玲

Zhonghua Xue Ye Xue Za Zhi. 2022 Jun; 43(6): 499–505. Chinese. doi: 10.3760/cma.j.issn.0253-2727.2022.06.010

PMCID:: PMC9800214

Abstract Article PDF–1.3M

Select item 977132611.

Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1

Mingzhe Li, Jiaxin Zhou, Zhengkui Zhang, Jisong Li, Feng Wang, Ling Ma, Xiaodong Tian, Zebin Mao, Yinmo Yang

Chin Med J (Engl) 2022 Oct 5; 135(19): 2326–2337. Published online 2022 Nov 17. doi: 10.1097/CM9.0000000000002154

PMCID:: PMC9771326

Abstract Article PDF–5.2M

Select item 934857612.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 927928513.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 911973614.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 888114415.

Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis

Karla E. Merz, Ragadeepthi Tunduguru, Miwon Ahn, Vishal A. Salunkhe, Rajakrishnan Veluthakal, Jinhee Hwang, Supriyo Bhattacharya, Erika M. McCown, Pablo A. Garcia, Chunxue Zhou, Eunjin Oh, Stephanie M. Yoder, Jeffrey S. Elmendorf, Debbie C. Thurmond

Front Endocrinol (Lausanne) 2022; 13: 821849. Published online 2022 Feb 11. doi: 10.3389/fendo.2022.821849

PMCID:: PMC8881144

Abstract Article PDF–7.7M

Select item 876907216.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 860245117.

Identification of proximal SUMO-dependent interactors using SUMO-ID

Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland

Nat Commun. 2021; 12: 6671. Published online 2021 Nov 18. doi: 10.1038/s41467-021-26807-6

PMCID:: PMC8602451

Abstract Article PDF–11M

Select item 831454718.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 820346819.

DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome

Xiao-Yan Tang, Lei Xu, Jingshen Wang, Yuan Hong, Yuanyuan Wang, Qian Zhu, Da Wang, Xin-Yue Zhang, Chun-Yue Liu, Kai-Heng Fang, Xiao Han, Shihua Wang, Xin Wang, Min Xu, Anita Bhattacharyya, Xing Guo, Mingyan Lin, Yan Liu

J Clin Invest. 2021 Jun 15; 131(12): e135763. Published online 2021 Jun 15. doi: 10.1172/JCI135763

PMCID:: PMC8203468

Abstract Article PDF–5.8M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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