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Select item 112579451.

Retinoic acid related orphan receptor α is a genetic modifier that rescues retinal degeneration in a mouse model of Stargardt disease and Dry AMD

M. Akula, S. M. McNamee, Z. Love, N. Nasraty, N. P. M. Chan, M. Whalen, M. O. Avola, A. M. Olivares, B. D. Leehy, A. S. Jelcick, P. Singh, A. K. Upadhyay, D. F. Chen, N. B. Haider

Gene Ther. 2024; 31(7-8): 413–421. Published online 2024 May 16. doi: 10.1038/s41434-024-00455-z

PMCID:: PMC11257945

Abstract Article PDF–2.2M

Select item 112512892.

Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene

Silvia Sánchez-Martin, Antonio Altuna-Coy, Verónica Arreaza-Gil, Xana Bernal-Escoté, Joan Francesc Garcia Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas, Matilde R. Chacón

J Transl Med. 2024; 22: 661. Published online 2024 Jul 15. doi: 10.1186/s12967-024-05458-3

PMCID:: PMC11251289

Abstract Article PDF–3.4M

Select item 107666233.

The single-cell transcriptomic atlas and RORA-mediated 3D epigenomic remodeling in driving corneal epithelial differentiation

Mingsen Li, Huizhen Guo, Bofeng Wang, Zhuo Han, Siqi Wu, Jiafeng Liu, Huaxing Huang, Jin Zhu, Fengjiao An, Zesong Lin, Kunlun Mo, Jieying Tan, Chunqiao Liu, Li Wang, Xin Deng, Guigang Li, Jianping Ji, Hong Ouyang

Nat Commun. 2024; 15: 256. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44471-w

PMCID:: PMC10766623

Abstract Article PDF–8.2M

Select item 99590494.

Novel Therapeutic Potential of Retinoid-Related Orphan Receptor α in Cardiovascular Diseases

Yun Chen, Shu-Ping Zhang, Wei-Wei Gong, Yang-Yang Zheng, Jie-Ru Shen, Xiao Liu, Yun-Hui Gu, Jia-Hai Shi, Guo-Liang Meng

Int J Mol Sci. 2023 Feb; 24(4): 3462. Published online 2023 Feb 9. doi: 10.3390/ijms24043462

PMCID:: PMC9959049

Abstract Article PDF–3.2M

Select item 98075265.

ROS inhibits RORα degradation by decreasing its arginine methylation in liver cancer

Hyuntae Im, Hee‐ji Baek, Eunbi Yang, Kyeongkyu Kim, Se Kyu Oh, Jung‐Shin Lee, Hyunkyung Kim, Ji Min Lee

Cancer Sci. 2023 Jan; 114(1): 187–200. Published online 2022 Oct 1. doi: 10.1111/cas.15595

PMCID:: PMC9807526

Abstract Article PDF–7.6M

Select item 95275896.

ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease

Zhifeng Bai, Yuanyuan Luo, Linyun Tian

FEBS Open Bio. 2022 Oct; 12(10): 1814–1827. Published online 2022 Aug 7. doi: 10.1002/2211-5463.13469

PMCID:: PMC9527589

Abstract Article PDF–2.7M

Select item 92185147.

Retinoid orphan nuclear receptor alpha (RORα) suppresses the epithelial–mesenchymal transition (EMT) by directly repressing Snail transcription

Gaofeng Xiong, Ren Xu

J Biol Chem. 2022 Jul; 298(7): 102059. Published online 2022 May 20. doi: 10.1016/j.jbc.2022.102059

PMCID:: PMC9218514

Abstract Article PDF–3.4M

Select item 90649418.

The disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases

Anna A Brozyna, Michał A Żmijewski, Kinga Linowiecka, Tae-Kang Kim, Radomir M Slominski, Andrzej T Slominski

Exp Dermatol. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Exp Dermatol. 2022 May; 31(5): 781–788. Published online 2022 Jan 13. doi: 10.1111/exd.14521

PMCID:: PMC9064941

Abstract Article PDF–931K

Select item 87213609.

RORα and REV-ERBα are Associated With Clinicopathological Parameters and are Independent Biomarkers of Prognosis in Gastric Cancer

Xiaoshan Wang, Ru Jia, Ke Chen, Jingjing Wang, Kai Jiang, Zhengguang Wang

Technol Cancer Res Treat. 2021; 20: 15330338211039670. Published online 2021 Dec 21. doi: 10.1177/15330338211039670

PMCID:: PMC8721360

Abstract Article PDF–3.1M

Select item 852491510.

CircGSK3B promotes RORA expression and suppresses gastric cancer progression through the prevention of EZH2 trans-inhibition

Xianxiong Ma, Hengyu Chen, Lei Li, Feng Yang, Chuanqing Wu, Kaixiong Tao

J Exp Clin Cancer Res. 2021; 40: 330. Published online 2021 Oct 19. doi: 10.1186/s13046-021-02136-w

PMCID:: PMC8524915

Abstract Article PDF–14M

Select item 847897811.

Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway

Tongzhou Liang, Taiqiu Chen, Jincheng Qiu, Wenjie Gao, Xianjian Qiu, Yuanxin Zhu, Xudong Wang, Yanbo Chen, Hang Zhou, Zhihuai Deng, Pengfei Li, Caixia Xu, Yan Peng, Anjing Liang, Peiqiang Su, Bo Gao, Dongsheng Huang

Cell Death Dis. 2021 Oct; 12(10): 886. Published online 2021 Sep 28. doi: 10.1038/s41419-021-04170-0

PMCID:: PMC8478978

Abstract Article PDF–6.2M

Select item 838499512.

Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth

Johanna M. Huusko, Heli Tiensuu, Antti M. Haapalainen, Anu Pasanen, Pinja Tissarinen, Minna K. Karjalainen, Ge Zhang, Kaare Christensen, Kelli K. Ryckman, Bo Jacobsson, Jeffrey C. Murray, Stephen F. Kingsmore, Mikko Hallman, Louis J. Muglia, Mika Rämet

Sci Rep. 2021; 11: 17115. Published online 2021 Aug 24. doi: 10.1038/s41598-021-96374-9

PMCID:: PMC8384995

Abstract Article PDF–2.6M

Select item 786643013.

Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility

Clara Benna, Senthilkumar Rajendran, Giovanna Spiro, Chiara Menin, Luigi Dall’Olmo, Carlo Riccardo Rossi, Simone Mocellin

J Transl Med. 2021; 19: 57. Published online 2021 Feb 6. doi: 10.1186/s12967-021-02725-5

PMCID:: PMC7866430

Abstract Article PDF–957K

Select item 783521814.

Tumor exosome promotes Th17 cell differentiation by transmitting the lncRNA CRNDE-h in colorectal cancer

Junfeng Sun, Haowei Jia, Xingqi Bao, Yue Wu, Tianyu Zhu, Ruixin Li, Hongchao Zhao

Cell Death Dis. 2021 Jan; 12(1): 123. Published online 2021 Jan 25. doi: 10.1038/s41419-020-03376-y

PMCID:: PMC7835218

Abstract Article PDF–4.9M

Select item 770223215.

Sedigheh Farahani, Leila Solgi, Sahar Bayat, Atieh Abedin Do, Shohreh Zare‐Karizi, Behnam Safarpour Lima, Reza Mirfakhraie

CNS Neurosci Ther. 2020 Dec; 26(12): 1315–1321. Published online 2020 Sep 5. doi: 10.1111/cns.13453

PMCID:: PMC7702232

Abstract Article PDF–949K

Select item 764684116.

lncRNA FGD5 antisense RNA 1 upregulates RORA to suppress hypoxic injury of human cardiomyocyte cells by inhibiting oxidative stress and apoptosis via miR-195

Xinyong Cai, Ping Zhang, Shu Wang, Lang Hong, Songping Yu, Bin Li, Hong Zeng, Xu Yang, Liang Shao

Mol Med Rep. 2020 Dec; 22(6): 4579–4588. Published online 2020 Oct 2. doi: 10.3892/mmr.2020.11558

PMCID:: PMC7646841

Abstract Article PDF–1.6M

Select item 752726117.

RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells

Hao Hu, Masahiko Negishi

Biochem J. 2020 Sep 30; 477(18): 3583–3598. Prepublished online 2020 Jul 20. Published online 2020 Sep 28. doi: 10.1042/BCJ20200427

PMCID:: PMC7527261

Abstract Article PDF–2.5M

Select item 748242718.

Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity

Emily Hams, Joseph Roberts, Rachel Bermingham, Andrew E. Hogan, Donal O'Shea, Luke O'Neill, Padraic G. Fallon

Front Immunol. 2020; 11: 1966. Published online 2020 Aug 27. doi: 10.3389/fimmu.2020.01966

PMCID:: PMC7482427

Abstract Article PDF–2.3M

Select item 731041019.

Retinoic acid receptor-related orphan receptor α reduces lipid droplets by upregulating neutral cholesterol ester hydrolase 1 in macrophages

Hiroshi Matsuoka, Riki Tokunaga, Miyu Katayama, Yuichiro Hosoda, Kaoruko Miya, Kento Sumi, Ami Ohishi, Jun Kamishikiryo, Akiho Shima, Akihiro Michihara

BMC Mol Cell Biol. 2020; 21: 32. Published online 2020 Apr 22. doi: 10.1186/s12860-020-00276-z

PMCID:: PMC7310410

Abstract Article PDF–2.1M

Select item 724680520.

Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation

Hiroshi Matsuoka, Miyu Katayama, Ami Ohishi, Kaoruko Miya, Riki Tokunaga, Sou Kobayashi, Yuya Nishimoto, Kazutake Hirooka, Akiho Shima, Akihiro Michihara

Int J Mol Sci. 2020 May; 21(9): 3309. Published online 2020 May 7. doi: 10.3390/ijms21093309