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Items: 1 to 20 of 358

1.
Bromodomain-containing protein 4 (BRD4): A key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics
Zonghui Ma, Andrew A. Bolinger, Jia Zhou, Bing Tian
Expert Opin Ther Targets. Author manuscript; available in PMC 2024 May 14.
Published in final edited form as: Expert Opin Ther Targets. 2023 Jan; 27(1): 1–7. Published online 2023 Feb 7. doi: 10.1080/14728222.2023.2175317
PMCID:
PMC11092387
AbstractArticlePDF–821K
2.
Cooperative interaction of interferon regulatory factor -1 and bromodomain—containing protein 4 on RNA polymerase activation for intrinsic innate immunity
Xiaofang Xu, Dianhua Qiao, Allan R. Brasier
Front Immunol. 2024; 15: 1366235. Published online 2024 Mar 27. doi: 10.3389/fimmu.2024.1366235
PMCID:
PMC11004252
AbstractArticlePDF–8.6M
3.
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Felipe Andreiuolo, Christina K. Ferrone, Sharika Rajan, Arie Perry, Ekin Guney, Elaine Cham, Caterina Giannini, Angus Toland, Nicholas Willard, Andrea Silveira de Souza, Karen Dazelle, Hye-Jung Chung, Omkar Singh, Kyle Conway, Nicholas Coley, Christopher Dampier, Zied Abdullaev, Drew Pratt, Patrick J. Cimino, Martha Quezado, Kenneth Aldape
Acta Neuropathol Commun. 2024; 12: 42. Published online 2024 Mar 18. doi: 10.1186/s40478-024-01746-7
PMCID:
PMC10946093
AbstractArticlePDF–3.2M
4.
The P53–P21–RB1 pathway promotes BRD4 degradation in liver cancer through USP1
Neng Li, Erlei Zhang, Zhenyong Li, Suli Lv, Xuefeng Zhao, Qian Ke, Qingli Zou, Wensheng Li, Yifei Wang, Haocheng Guo, Tanjing Song, Lidong Sun
J Biol Chem. 2024 Mar; 300(3): 105707. Published online 2024 Feb 1. doi: 10.1016/j.jbc.2024.105707
PMCID:
PMC10907170
AbstractArticlePDF–2.0M
5.
p53 gain-of-function mutation induces metastasis via Brd4-dependent Csf-1 expression
Gizem Efe, Karen J. Dunbar, Kensuke Sugiura, Katherine Cunningham, Saul Carcamo, Spyros Karaiskos, Qiaosi Tang, Ricardo Cruz-Acuña, Lois Resnick-Silverman, Jessica Peura, Chao Lu, Dan Hasson, Andres J. Klein-Szanto, Alison M. Taylor, James J. Manfredi, Carol Prives, Anil K. Rustgi
Cancer Discov. Author manuscript; available in PMC 2024 Jun 12.
Published in final edited form as: Cancer Discov. 2023 Dec 12; 13(12): 2632–2651. doi: 10.1158/2159-8290.CD-23-0601
PMCID:
PMC10841313
AbstractArticlePDF–1.3M
6.
Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer
Shasha Li, Lulu Wang, Jing Shi, Yi Chen, Ang Xiao, Bingyue Huo, Wenjing Tian, Shilu Zhang, Gang Yang, Wensheng Gong, Huixia Zhang
PeerJ. 2024; 12: e16752. Published online 2024 Jan 10. doi: 10.7717/peerj.16752
PMCID:
PMC10787542
AbstractArticlePDF–13M
7.
Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
Apurva T. Prabhakar, Claire D. James, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Calvin Yeager, Ronald D. Hill, Aanchal Dubey, Shwu-Yuan Wu, Cheng-Ming Chiang, Iain M. Morgan
J Virol. 2023 Oct; 97(10): e00782-23. Published online 2023 Sep 15. doi: 10.1128/jvi.00782-23
PMCID:
PMC10617519
AbstractArticlePDF–2.7M
8.
HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
Viacheslav M Morozov, Alberto Riva, Sadia Sarwar, Wan-Ju Kim, Jianping Li, Lei Zhou, Jonathan D Licht, Yehia Daaka, Alexander M Ishov
Nucleic Acids Res. 2023 Oct 27; 51(19): 10194–10217. Published online 2023 Aug 28. doi: 10.1093/nar/gkad700
PMCID:
PMC10602887
AbstractArticlePDF–3.9M
9.
JMJD6–BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells
Ruifeng Pei, Le Zhao, Yiren Ding, Zhan Su, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao, Wuyuan Zhou
J Transl Med. 2023; 21: 752. Published online 2023 Oct 25. doi: 10.1186/s12967-023-04394-y
PMCID:
PMC10599021
AbstractArticlePDF–3.0M
10.
A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair–targeted therapy
Xiao Lu, Lichao Peng, Jiancheng Ding, Yuanpei Li, Qing Li, Mengchen Rao, Tong Shu, Xiaoniu He, Chen Liu, Jing Ye, Wen Liu, Han You
Proc Natl Acad Sci U S A. 2023 Oct 10; 120(41): e2304534120. Published online 2023 Oct 2. doi: 10.1073/pnas.2304534120
PMCID:
PMC10576145
AbstractArticlePDF–2.6M
11.
Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription
Donald P. Cameron, Jan Grosser, Swetlana Ladigan, Vladislav Kuzin, Evanthia Iliopoulou, Anika Wiegard, Hajar Benredjem, Kathryn Jackson, Sven T. Liffers, Smiths Lueong, Phyllis F. Cheung, Deepak Vangala, Michael Pohl, Richard Viebahn, Christian Teschendorf, Heiner Wolters, Selami Usta, Keyi Geng, Claudia Kutter, Marie Arsenian-Henriksson, Jens T. Siveke, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn, Laura Baranello
Sci Adv. 2023 Oct 13; 9(41): eadg5109. Published online 2023 Oct 13. doi: 10.1126/sciadv.adg5109
PMCID:
PMC10575591
AbstractArticlePDF–2.3M
12.
Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion
Yi Liu, Hejing Liu, Miaomiao Ye, Mengying Jiang, Xin Chen, Gendi Song, Huihui Ji, Zhi-wei Wang, Xueqiong Zhu
Cell Death Dis. 2023 Sep; 14(9): 624. Published online 2023 Sep 22. doi: 10.1038/s41419-023-06149-5
PMCID:
PMC10517134
AbstractArticlePDF–6.0M
13.
High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription
Annkatrin Bressin, Olga Jasnovidova, Mirjam Arnold, Elisabeth Altendorfer, Filip Trajkovski, Thomas A. Kratz, Joanna E. Handzlik, Denes Hnisz, Andreas Mayer
Nat Commun. 2023; 14: 4971. Published online 2023 Aug 17. doi: 10.1038/s41467-023-40633-y
PMCID:
PMC10435483
AbstractArticlePDF–2.5M
14.
Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion
Hua Yu, Tiezhu Shi, Linli Yao, Dongwei Xu, Yufeng Ding, Qiang Xia, Wei Liu, Xiongjun Wang
Cell Mol Immunol. 2023 Aug; 20(8): 867–880. Published online 2023 Jun 7. doi: 10.1038/s41423-023-01048-3
PMCID:
PMC10387471
AbstractArticlePDF–16M
15.
Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing
Morgan W. Mann, Yao Fu, Robert L. Gearhart, Xiaofang Xu, David S. Roberts, Yi Li, Jia Zhou, Ying Ge, Allan R. Brasier
Front Immunol. 2023; 14: 1212770. Published online 2023 Jun 26. doi: 10.3389/fimmu.2023.1212770
PMCID:
PMC10331468
AbstractArticlePDF–3.5M
16.
High Expression Level of BRD4 Is Associated with a Poor Prognosis and Immune Infiltration in Esophageal Squamous Cell Carcinoma
Li Li, Lin Gao, Hong Zhou, Chao Shi, Xiaojuan Zhang, Dongmei Zhang, Hongbin Liu
Dig Dis Sci. 2023; 68(7): 2997–3008. Published online 2023 Mar 18. doi: 10.1007/s10620-023-07907-3
PMCID:
PMC10293338
AbstractArticlePDF–12M
17.
Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt
J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706
PMCID:
PMC10243116
AbstractArticlePDF–13M
18.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
19.
BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors
Yu Fu, Bin Yang, Yaoyuan Cui, Xingyuan Hu, Xi Li, Funian Lu, Tianyu Qin, Li Zhang, Zhe Hu, Ensong Guo, Junpeng Fan, Rourou Xiao, Wenting Li, Xu Qin, Dianxing Hu, Wenju Peng, Jingbo Liu, Beibei Wang, Gordon B Mills, Gang Chen, Chaoyang Sun
J Immunother Cancer. 2023; 11(4): e006070. Published online 2023 Apr 17. doi: 10.1136/jitc-2022-006070
PMCID:
PMC10124306
AbstractArticlePDF–13M
20.
Screening of an epigenetic compound library identifies BRD4 as a potential antiviral target for hepatitis B virus covalently closed circular DNA transcription
Xiaoyang Yu, Quanxin Long, Sheng Shen, Zhentao Liu, Jithin Chandran, Junjie Zhang, Hao Ding, Hu Zhang, Dawei Cai, Elena S. Kim, Yufei Huang, Haitao Guo
Antiviral Res. Author manuscript; available in PMC 2024 Mar 1.
Published in final edited form as: Antiviral Res. 2023 Mar; 211: 105552. Published online 2023 Feb 1. doi: 10.1016/j.antiviral.2023.105552
PMCID:
PMC10036215
AbstractArticlePDF–2.4M

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