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Select item 111150091.

Light on the structure of thromboxane A₂ receptor heterodimers

Francesca Fanelli, Mario Mauri, Valérie Capra, Francesco Raimondi, Francesca Guzzi, Manuela Ambrosio, G. Enrico Rovati, Marco Parenti

Cell Mol Life Sci. 2011 Sep; 68(18): 3109–3120. Published online 2011 Jan 7. doi: 10.1007/s00018-010-0615-0

PMCID:: PMC11115009

Abstract Article PDF–600K

Select item 100182272.

In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India

Indranil Ganai, Ishita Saha, Priyajit Banerjee, Arghya Laha, Saheen Sultana, Nasima Sultana, Himani Biswas, Saibal Moitra, Sanjoy Podder

Front Immunol. 2023; 14: 1089514. Published online 2023 Mar 1. doi: 10.3389/fimmu.2023.1089514

PMCID:: PMC10018227

Abstract Article PDF–4.5M

Select item 98491413.

A proteome-scale map of the SARS-CoV-2–human contactome

Dae-Kyum Kim, Benjamin Weller, Chung-Wen Lin, Dayag Sheykhkarimli, Jennifer J. Knapp, Guillaume Dugied, Andreas Zanzoni, Carles Pons, Marie J. Tofaute, Sibusiso B. Maseko, Kerstin Spirohn, Florent Laval, Luke Lambourne, Nishka Kishore, Ashyad Rayhan, Mayra Sauer, Veronika Young, Hridi Halder, Nora Marín-de la Rosa, Oxana Pogoutse, Alexandra Strobel, Patrick Schwehn, Roujia Li, Simin T. Rothballer, Melina Altmann, Patricia Cassonnet, Atina G. Coté, Lena Elorduy Vergara, Isaiah Hazelwood, Betty B. Liu, Maria Nguyen, Ramakrishnan Pandiarajan, Bushra Dohai, Patricia A. Rodriguez Coloma, Juline Poirson, Paolo Giuliana, Luc Willems, Mikko Taipale, Yves Jacob, Tong Hao, David E. Hill, Christine Brun, Jean-Claude Twizere, Daniel Krappmann, Matthias Heinig, Claudia Falter, Patrick Aloy, Caroline Demeret, Marc Vidal, Michael A. Calderwood, Frederick P. Roth, Pascal Falter-Braun

Nat Biotechnol. 2023; 41(1): 140–149. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01475-z

PMCID:: PMC9849141

Abstract Article PDF–7.1M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699835.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 64362146.

The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke

Xingyang Yi, Jing Lin, Qiang Zhou, Ruyue Huang, Zhenxiao Chai

BMC Neurol. 2019; 19: 44. Published online 2019 Mar 26. doi: 10.1186/s12883-019-1271-0

PMCID:: PMC6436214

Abstract Article PDF–576K

Select item 61839277.

TBXA2R gene variants associated with bleeding

Stuart James Mundell, Andrew Mumford

Platelets. 2018; 29(7): 739–742. Published online 2018 Aug 8. doi: 10.1080/09537104.2018.1499888

PMCID:: PMC6183927

Abstract Article PDF–353K

Select item 60777228.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 57376349.

Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS

Thangavel Samikkannu, Marisela Agudelo, Nimisha Gandhi, Pichili V. B. Reddy, Zainulabedin M. Saiyed, Donald Nwankwo, Madhavan P. N. Nair

J Neurovirol. Author manuscript; available in PMC 2017 Dec 20.

Published in final edited form as: J Neurovirol. 2011 Jun; 17(3): 230–238. Published online 2011 Apr 14. doi: 10.1007/s13365-011-0026-5

PMCID:: PMC5737634

Abstract Article PDF–553K

Select item 550751410.

Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients

Xingyang Yi, Jing Lin, Hua Luo, Chun Wang, Yingying Liu

PLoS One. 2017; 12(7): e0180704. Published online 2017 Jul 12. doi: 10.1371/journal.pone.0180704

PMCID:: PMC5507514

Abstract Article PDF–922K

Select item 544472311.

Hyperglycemia via activation of thromboxane A2 receptor impairs the integrity and function of blood-brain barrier in microvascular endothelial cells

Zhihong Zhao, Jue Hu, Xiaoping Gao, Hui Liang, Haiya Yu, Suosi Liu, Zhan Liu

Oncotarget. 2017 May 2; 8(18): 30030–30038. Published online 2017 Mar 16. doi: 10.18632/oncotarget.16273

PMCID:: PMC5444723

Abstract Article PDF–2.6M

Select item 534242912.

Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)

Katy Orr, Niamh E. Buckley, Paula Haddock, Colin James, Jean-Luc Parent, Stephen McQuaid, Paul B. Mullan

Oncotarget. 2016 Aug 23; 7(34): 55458–55472. Published online 2016 Jul 30. doi: 10.18632/oncotarget.10969

PMCID:: PMC5342429

Abstract Article PDF–8.8M

Select item 534197113.

Expression of the TPα and TPβ isoforms of the thromboxane prostanoid receptor (TP) in prostate cancer: clinical significance and diagnostic potential

Eamon P. Mulvaney, Christine Shilling, Sarah B. Eivers, Antoinette S. Perry, Anders Bjartell, Elaine W. Kay, R. William Watson, B. Therese Kinsella

Oncotarget. 2016 Nov 8; 7(45): 73171–73187. Published online 2016 Sep 26. doi: 10.18632/oncotarget.12256

PMCID:: PMC5341971

Abstract Article PDF–7.1M

Select item 517060414.

Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex

Samuel Génier, Jade Degrandmaison, Pierrick Moreau, Pascale Labrecque, Terence E. Hébert, Jean-Luc Parent

Mol Biol Cell. 2016 Dec 1; 27(24): 3800–3812. doi: 10.1091/mbc.E16-04-0224

PMCID:: PMC5170604

Abstract Article PDF–4.9M

Select item 509941815.

Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy

Ling-ling Peng, Yuan-qi Zhao, Zi-yi Zhou, Jing Jin, Min Zhao, Xin-meng Chen, Ling-yan Chen, Ye-feng Cai, Jia-li Li, Min Huang

Acta Pharmacol Sin. 2016 Nov; 37(11): 1442–1448. Published online 2016 Sep 19. doi: 10.1038/aps.2016.90

PMCID:: PMC5099418

Abstract Article PDF–237K

Select item 492948116.

Role for the thromboxane A₂ receptor β-isoform in the pathogenesis of intrauterine growth restriction

Katie L. Powell, Veronica Stevens, Dannielle H. Upton, Sharon A. McCracken, Ann M. Simpson, Yan Cheng, Vitomir Tasevski, Jonathan M. Morris, Anthony W. Ashton

Sci Rep. 2016; 6: 28811. Published online 2016 Jul 1. doi: 10.1038/srep28811

PMCID:: PMC4929481

Abstract Article PDF–2.8M

Select item 481349917.

Thromboxane A₂ Receptor Inhibition Suppresses Multiple Myeloma Cell Proliferation by Inducing p38/c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase (MAPK)-mediated G₂/M Progression Delay and Cell Apoptosis

Qian Liu, Bo Tao, Guizhu Liu, Guilin Chen, Qian Zhu, Ying Yu, Yu Yu, Hong Xiong

J Biol Chem. 2016 Feb 26; 291(9): 4779–4792. Published online 2016 Jan 2. doi: 10.1074/jbc.M115.683052

PMCID:: PMC4813499

Abstract Article PDF–4.9M

Select item 451507218.

The Wilms’ tumour suppressor protein WT1 acts as a key transcriptional repressor of the human thromboxane A₂ receptor gene in megakaryocytes

AnneMarie M Gannon, B Therese Kinsella

J Cell Mol Med. 2009 Nov-Dec; 13(11-12): 4571–4586. Published online 2008 Dec 3. doi: 10.1111/j.1582-4934.2008.00599.x

PMCID:: PMC4515072

Abstract Article PDF–1.1M

Select item 440576419.

A novel thromboxane A₂ receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis

Andrew D. Mumford, Ban B. Dawood, Martina E. Daly, Sherina L. Murden, Michael D. Williams, Majd B. Protty, Jennifer C. Spalton, Mark Wheatley, Stuart J. Mundell, Steve P. Watson

Blood. Author manuscript; available in PMC 2015 Apr 22.

Published in final edited form as: Blood. 2010 Jan 14; 115(2): 363–369. Published online 2009 Oct 14. doi: 10.1182/blood-2009-08-236976

Correction in:: Blood, volume 119 on page 4092

PMCID:: PMC4405764

Abstract Article PDF–994K

Select item 415933220.

Regulation of the Tumor Suppressor FOXO3 by the Thromboxane-A₂ Receptors in Urothelial Cancer

Philip M. Sobolesky, Perry V. Halushka, Elizabeth Garrett-Mayer, Michael T. Smith, Omar Moussa

PLoS One. 2014; 9(9): e107530. Published online 2014 Sep 9. doi: 10.1371/journal.pone.0107530

PMCID:: PMC4159332

Abstract Article PDF–957K

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