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Select item 88970221.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 65140803.

De novo and inherited loss-of-function variants of ATP2B2 are associated with rapidly progressive hearing impairment

Jeroen J. Smits, Jaap Oostrik, Andy J. Beynon, Sarina G. Kant, Pia A. M. de Koning Gans, Liselotte J. C. Rotteveel, Jolien S. Klein Wassink-Ruiter, Rolien H. Free, Saskia M. Maas, Jiddeke van de Kamp, Paul Merkus, DOOFNL Consortium, Wouter Koole, Ilse Feenstra, Ronald J. C. Admiraal, Cornelis P. Lanting, Margit Schraders, Helger G. Yntema, Ronald J. E. Pennings, Hannie Kremer

Hum Genet. 2019; 138(1): 61–72. Published online 2018 Dec 8. doi: 10.1007/s00439-018-1965-1

PMCID:: PMC6514080

Abstract Article PDF–1.2M

Select item 61007244.

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

Gustav N Sundell, Roland Arnold, Muhammad Ali, Piangfan Naksukpaiboon, Julien Orts, Peter Güntert, Celestine N Chi, Ylva Ivarsson

Mol Syst Biol. 2018 Aug; 14(8): e8129. Published online 2018 Aug 20. doi: 10.15252/msb.20178129

PMCID:: PMC6100724

Abstract Article PDF–2.4M

Select item 55316115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 53991076.

The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2

Jaekwang Jeong, Joshua N. VanHouten, Wonnam Kim, Pamela Dann, Catherine Sullivan, Jungmin Choi, W. Bruce Sneddon, Peter A. Friedman, John J. Wysolmerski

J Biol Chem. 2017 Apr 21; 292(16): 6555–6568. Published online 2017 Feb 24. doi: 10.1074/jbc.M116.770883

PMCID:: PMC5399107

Abstract Article PDF–5.8M

Select item 50365277.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

Select item 48691708.

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, Konstantinos Koutroumpas, Thanh-Minh T. Nguyen, Yves Texier, Sylvia E. C. van Beersum, Nicola Horn, Jason R. Willer, Dorus A. Mans, Gerard Dougherty, Ideke J. C. Lamers, Karlien L. M. Coene, Heleen H. Arts, Matthew J. Betts, Tina Beyer, Emine Bolat, Christian Johannes Gloeckner, Khatera Haidari, Lisette Hetterschijt, Daniela Iaconis, Dagan Jenkins, Franziska Klose, Barbara Knapp, Brooke Latour, Stef J. F. Letteboer, Carlo L. Marcelis, Dragana Mitic, Manuela Morleo, Machteld M. Oud, Moniek Riemersma, Susan Rix, Paulien A. Terhal, Grischa Toedt, Teunis J. P. van Dam, Erik de Vrieze, Yasmin Wissinger, Ka Man Wu, Gordana Apic, Philip L. Beales, Oliver E. Blacque, Toby J. Gibson, Martijn A. Huynen, Nicholas Katsanis, Hannie Kremer, Heymut Omran, Erwin van Wijk, Uwe Wolfrum, François Kepes, Erica E. Davis, Brunella Franco, Rachel H. Giles, Marius Ueffing, Robert B. Russell, Ronald Roepman, UK10K Rare Diseases Group

Nat Commun. 2016; 7: 11491. Published online 2016 May 13. doi: 10.1038/ncomms11491

PMCID:: PMC4869170

Abstract Article PDF–2.0M

Select item 48577939.

The calcium pump plasma membrane Ca²⁺-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin

Amelia A. Peters, Michael J. G. Milevskiy, Wei C. Lee, Merril C. Curry, Chanel E. Smart, Jodi M. Saunus, Lynne Reid, Leonard da Silva, Daneth L. Marcial, Eloise Dray, Melissa A. Brown, Sunil R. Lakhani, Sarah J. Roberts-Thomson, Gregory R. Monteith

Sci Rep. 2016; 6: 25505. Published online 2016 May 5. doi: 10.1038/srep25505

PMCID:: PMC4857793

Abstract Article PDF–2.0M

Select item 472547310.

PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer

Jaekwang Jeong, Joshua N. VanHouten, Pamela Dann, Wonnam Kim, Catherine Sullivan, Herbert Yu, Lance Liotta, Virginia Espina, David F. Stern, Peter A. Friedman, John J. Wysolmerski

Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3): E282–E290. Published online 2016 Jan 4. doi: 10.1073/pnas.1516138113

PMCID:: PMC4725473

Abstract Article PDF–2.5M

Select item 461721111.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 461025712.

Systematic VCP-UBXD Adaptor Network Proteomics Identifies a Role for UBXN10 in Regulating Ciliogenesis

Malavika Raman, Mikhail Sergeev, Maija Garnaas, John R. Lydeard, Edward L. Huttlin, Wolfram Goessling, Jagesh V. Shah, J. Wade Harper

Nat Cell Biol. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nat Cell Biol. 2015 Oct; 17(10): 1356–1369. Published online 2015 Sep 21. doi: 10.1038/ncb3238

Correction in:: Nat Cell Biol. 2016 Mar; 18(3): 347.

PMCID:: PMC4610257

Abstract Article PDF–4.5M

Select item 397730513.

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

Kendra S. Carmon, Xing Gong, Jing Yi, Anthony Thomas, Qingyun Liu

Proc Natl Acad Sci U S A. 2014 Apr 1; 111(13): E1221–E1229. Published online 2014 Mar 17. doi: 10.1073/pnas.1323106111

PMCID:: PMC3977305

Abstract Article PDF–1.7M

Select item 363120014.

The Evidence for Association of ATP2B2 Polymorphisms with Autism in Chinese Han Population

Wen Yang, Jing Liu, Fanfan Zheng, Meixiang Jia, Linnan Zhao, Tianlan Lu, Yanyan Ruan, Jishui Zhang, Weihua Yue, Dai Zhang, Lifang Wang

PLoS One. 2013; 8(4): e61021. Published online 2013 Apr 19. doi: 10.1371/journal.pone.0061021

PMCID:: PMC3631200

Abstract Article PDF–185K

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 313943216.

Apical localization of PMCA2w/b is enhanced in terminally polarized MDCK cells

Géza Antalffy, Ariel J. Caride, Katalin Pászty, Luca Hegedus, Rita Padanyi, Emanuel E. Strehler, Ágnes Enyedi

Biochem Biophys Res Commun. Author manuscript; available in PMC 2012 Jul 1.

Published in final edited form as: Biochem Biophys Res Commun. 2011 Jul 1; 410(2): 322–327. Published online 2011 Jun 6. doi: 10.1016/j.bbrc.2011.05.147

PMCID:: PMC3139432

Abstract Article PDF–1.0M

Select item 295124217.

Apical Scaffolding Protein NHERF2 Modulates the Localization of Alternatively Spliced Plasma Membrane Ca²⁺ Pump 2B Variants in Polarized Epithelial Cells

Rita Padányi, Yuning Xiong, Géza Antalffy, Krisztina Lór, Katalin Pászty, Emanuel E. Strehler, Ágnes Enyedi

J Biol Chem. 2010 Oct 8; 285(41): 31704–31712. Published online 2010 Jul 27. doi: 10.1074/jbc.M110.164137

PMCID:: PMC2951242

Abstract Article PDF–2.5M

Select item 294516818.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452