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Select item 100729061.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100339372.

Assessment of community efforts to advance network-based prediction of protein–protein interactions

Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu

Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7

PMCID:: PMC10033937

Abstract Article PDF–1.5M

Select item 91011883.

Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding

Lara Barthold, Sebastian Heber, Christoph Q. Schmidt, Marion Gradl, Gilbert Weidinger, Holger Barth, Stephan Fischer

Int J Mol Sci. 2022 May; 23(9): 4509. Published online 2022 Apr 19. doi: 10.3390/ijms23094509

PMCID:: PMC9101188

Abstract Article PDF–20M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699835.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 70250396.

Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy

Shaozhen Feng, Zhong Zhong, Jinjin Fan, Xiaoyan Li, Dianchun Shi, Lanping Jiang

Dis Markers. 2020; 2020: 2078279. Published online 2020 Feb 5. doi: 10.1155/2020/2078279

Correction in:: Dis Markers. 2022; 2022: 9797825.

PMCID:: PMC7025039

Abstract Article PDF–806K

Select item 67426467.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 63975838.

Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments

D. Ehmann, J. Wendler, L. Koeninger, I. S. Larsen, T. Klag, J. Berger, A. Marette, M. Schaller, E. F. Stange, N. P. Malek, B. A. H. Jensen, J. Wehkamp

Proc Natl Acad Sci U S A. 2019 Feb 26; 116(9): 3746–3751. Published online 2019 Feb 11. doi: 10.1073/pnas.1817376116

PMCID:: PMC6397583

Abstract Article PDF–1.1M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 546642910.

Disentangling nanonets: Human α-defensin 6 targets C. albicans virulence

Lynette Cegelski

Biochemistry. Author manuscript; available in PMC 2017 Jun 9.

Published in final edited form as: Biochemistry. 2017 Feb 28; 56(8): 1027–1028. Published online 2017 Feb 15. doi: 10.1021/acs.biochem.7b00062

PMCID:: PMC5466429

Abstract Article PDF–313K

Select item 464794111.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 442438812.

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide

B O Schroeder, D Ehmann, J C Precht, P A Castillo, R Küchler, J Berger, M Schaller, E F Stange, J Wehkamp

Mucosal Immunol. 2015 May; 8(3): 661–671. Published online 2014 Nov 5. doi: 10.1038/mi.2014.100

PMCID:: PMC4424388

Abstract Article PDF–2.8M

Select item 433240613.

Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets

Hiutung Chu, Marzena Pazgier, Grace Jung, Sean-Paul Nuccio, Patricia A. Castillo, Maarten F. de Jong, Maria G. Winter, Sebastian E. Winter, Jan Wehkamp, Bo Shen, Nita H. Salzman, Mark A. Underwood, Renee M. Tsolis, Glenn M. Young, Wuyuan Lu, Robert I. Lehrer, Andreas J. Bäumler, Charles L. Bevins

Science. Author manuscript; available in PMC 2015 Feb 18.

Published in final edited form as: Science. 2012 Jul 27; 337(6093): 477–481. Published online 2012 Jun 21. doi: 10.1126/science.1218831

PMCID:: PMC4332406

Abstract Article PDF–1.1M

Select item 426658814.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 418363115.

Molecular Basis for Self-Assembly of a Human Host-Defense Peptide That Entraps Bacterial Pathogens

Phoom Chairatana, Elizabeth M. Nolan

J Am Chem Soc. 2014 Sep 24; 136(38): 13267–13276. Published online 2014 Aug 26. doi: 10.1021/ja5057906

PMCID:: PMC4183631

Abstract Article PDF–3.5M

Select item 408563616.

Gene-Age Interactions in Blood Pressure Regulation: A Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia

Jeannette Simino, Gang Shi, Joshua C. Bis, Daniel I. Chasman, Georg B. Ehret, Xiangjun Gu, Xiuqing Guo, Shih-Jen Hwang, Eric Sijbrands, Albert V. Smith, Germaine C. Verwoert, Jennifer L. Bragg-Gresham, Gemma Cadby, Peng Chen, Ching-Yu Cheng, Tanguy Corre, Rudolf A. de Boer, Anuj Goel, Toby Johnson, Chiea-Chuen Khor, LifeLines Cohort Study, Carla Lluís-Ganella, Jian’an Luan, Leo-Pekka Lyytikäinen, Ilja M. Nolte, Xueling Sim, Siim Sõber, Peter J. van der Most, Niek Verweij, Jing Hua Zhao, Najaf Amin, Eric Boerwinkle, Claude Bouchard, Abbas Dehghan, Gudny Eiriksdottir, Roberto Elosua, Oscar H. Franco, Christian Gieger, Tamara B. Harris, Serge Hercberg, Albert Hofman, Alan L. James, Andrew D. Johnson, Mika Kähönen, Kay-Tee Khaw, Zoltan Kutalik, Martin G. Larson, Lenore J. Launer, Guo Li, Jianjun Liu, Kiang Liu, Alanna C. Morrison, Gerjan Navis, Rick Twee-Hee Ong, George J. Papanicolau, Brenda W. Penninx, Bruce M. Psaty, Leslie J. Raffel, Olli T. Raitakari, Kenneth Rice, Fernando Rivadeneira, Lynda M. Rose, Serena Sanna, Robert A. Scott, David S. Siscovick, Ronald P. Stolk, Andre G. Uitterlinden, Dhananjay Vaidya, Melanie M. van der Klauw, Ramachandran S. Vasan, Eranga Nishanthie Vithana, Uwe Völker, Henry Völzke, Hugh Watkins, Terri L. Young, Tin Aung, Murielle Bochud, Martin Farrall, Catharina A. Hartman, Maris Laan, Edward G. Lakatta, Terho Lehtimäki, Ruth J.F. Loos, Gavin Lucas, Pierre Meneton, Lyle J. Palmer, Rainer Rettig, Harold Snieder, E. Shyong Tai, Yik-Ying Teo, Pim van der Harst, Nicholas J. Wareham, Cisca Wijmenga, Tien Yin Wong, Myriam Fornage, Vilmundur Gudnason, Daniel Levy, Walter Palmas, Paul M. Ridker, Jerome I. Rotter, Cornelia M. van Duijn, Jacqueline C.M. Witteman, Aravinda Chakravarti, Dabeeru C. Rao

Am J Hum Genet. 2014 Jul 3; 95(1): 24–38. doi: 10.1016/j.ajhg.2014.05.010

PMCID:: PMC4085636

Abstract Article PDF–1.2M

Select item 344865317.

Innate Immunity and Non-Hodgkin’s Lymphoma (NHL) Related Genes in a Nested Case-Control Study for Gastric Cancer Risk

Sue K. Park, Jae Jeong Yang, Sohee Oh, Lisa Y. Cho, Seung Hyun Ma, Aesun Shin, Kwang-Pil Ko, Taesung Park, Keun-Young Yoo, Daehee Kang

PLoS One. 2012; 7(9): e45274. Published online 2012 Sep 21. doi: 10.1371/journal.pone.0045274

PMCID:: PMC3448653

Abstract Article PDF–115K

Select item 319082618.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316916720.

Risk of Meningioma and Common Variation in Genes related to Innate Immunity

Preetha Rajaraman, Alina V. Brenner, Gila Neta, Ruth Pfeiffer, Sophia S. Wang, Meredith Yeager, Gilles Thomas, Howard A. Fine, Martha S. Linet, Nathaniel Rothman, Stephen J. Chanock, Peter D. Inskip

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 Sep 7.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 May; 19(5): 1356–1361. Published online 2010 Apr 20. doi: 10.1158/1055-9965.EPI-09-1151

PMCID:: PMC3169167

Abstract Article PDF–61K

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