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Select item 88217471.

Protein Kinase C Controls the Excitability of Cortical Pyramidal Neurons by Regulating Kv2.2 Channel Activity

Zhaoyang Li, Wenhao Dong, Xinyuan Zhang, Jun-Mei Lu, Yan-Ai Mei, Changlong Hu

Neurosci Bull. 2022 Feb; 38(2): 135–148. Published online 2021 Sep 20. doi: 10.1007/s12264-021-00773-x

PMCID:: PMC8821747

Abstract Article PDF–1.9M

Select item 85529072.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 85507593.

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja

eLife. 2021; 10: e65759. Published online 2021 Oct 27. doi: 10.7554/eLife.65759

PMCID:: PMC8550759

Abstract Article PDF–7.4M

Select item 82550274.

Kv2 channel–AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking

Emily E. Maverick, Ashley N. Leek, Michael M. Tamkun

J Cell Sci. 2021 Jun 15; 134(12): jcs256339. Published online 2021 Jun 17. doi: 10.1242/jcs.256339

PMCID:: PMC8255027

Abstract Article

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 77054506.

FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts

Thomas Di Mattia, Arthur Martinet, Souade Ikhlef, Alastair G McEwen, Yves Nominé, Corinne Wendling, Pierre Poussin‐Courmontagne, Laetitia Voilquin, Pascal Eberling, Frank Ruffenach, Jean Cavarelli, John Slee, Timothy P Levine, Guillaume Drin, Catherine Tomasetto, Fabien Alpy

EMBO J. 2020 Dec 1; 39(23): e104369. Published online 2020 Oct 30. doi: 10.15252/embj.2019104369

PMCID:: PMC7705450

Abstract Article PDF–4.4M

Select item 70215497.

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential

Leena Yadav, Elina Pietilä, Tiina Öhman, Xiaonan Liu, Arun K. Mahato, Yulia Sidorova, Kaisa Lehti, Mart Saarma, Markku Varjosalo

iScience. 2020 Feb 21; 23(2): 100871. Published online 2020 Jan 31. doi: 10.1016/j.isci.2020.100871

PMCID:: PMC7021549

Abstract Article PDF–8.1M

Select item 68399198.

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

Nicholas C Vierra, Michael Kirmiz, Deborah van der List, L Fernando Santana, James S Trimmer

eLife. 2019; 8: e49953. Published online 2019 Oct 30. doi: 10.7554/eLife.49953

PMCID:: PMC6839919

Abstract Article PDF–8.9M

Select item 58648329.

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

Xiaonan Liu, Kari Salokas, Fitsum Tamene, Yaming Jiu, Rigbe G. Weldatsadik, Tiina Öhman, Markku Varjosalo

Nat Commun. 2018; 9: 1188. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03523-2

PMCID:: PMC5864832

Abstract Article PDF–4.5M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 548207511.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Jianyang Fu, Xiaoqing Dai, Gregory Plummer, Kunimasa Suzuki, Austin Bautista, John M. Githaka, Laura Senior, Mette Jensen, Dafna Greitzer-Antes, Jocelyn E. Manning Fox, Herbert Y. Gaisano, Christopher B. Newgard, Nicolas Touret, Patrick E. MacDonald

Diabetes. 2017 Jul; 66(7): 1890–1900. Published online 2017 Jun 15. doi: 10.2337/db16-1170

PMCID:: PMC5482075

Abstract Article PDF–1.8M

Select item 503734512.

Pore size matters for potassium channel conductance

David Naranjo, Hans Moldenhauer, Matías Pincuntureo, Ignacio Díaz-Franulic

J Gen Physiol. 2016 Oct; 148(4): 277–291. doi: 10.1085/jgp.201611625

PMCID:: PMC5037345

Abstract Article PDF–1.6M

Select item 433481413.

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Sergio E. Baranzini, Joanne Wang, Rachel A. Gibson, Nicholas Galwey, Yvonne Naegelin, Frederik Barkhof, Ernst-Wilhelm Radue, Raija L.P. Lindberg, Bernard M.G. Uitdehaag, Michael R. Johnson, Aspasia Angelakopoulou, Leslie Hall, Jill C. Richardson, Rab K. Prinjha, Achim Gass, Jeroen J.G. Geurts, Jolijn Kragt, Madeleine Sombekke, Hugo Vrenken, Pamela Qualley, Robin R. Lincoln, Refujia Gomez, Stacy J. Caillier, Michaela F. George, Hourieh Mousavi, Rosa Guerrero, Darin T. Okuda, Bruce A. C. Cree, Ari J. Green, Emmanuelle Waubant, Douglas S. Goodin, Daniel Pelletier, Paul M. Matthews, Stephen L. Hauser, Ludwig Kappos, Chris H. Polman, Jorge R. Oksenberg

Hum Mol Genet. 2009 Feb 15; 18(4): 767–778. Published online 2008 Nov 14. doi: 10.1093/hmg/ddn388

PMCID:: PMC4334814

Abstract Article PDF–274K

Select item 428617914.

Genome-wide Association Studies of Maximum Number of Drinks

Yue Pan, Xingguang Luo, Xuefeng Liu, Long-Yang Wu, Qunyuan Zhang, Liang Wang, Weize Wang, Lingjun Zuo, Ke-Sheng Wang

J Psychiatr Res. Author manuscript; available in PMC 2015 Jan 7.

Published in final edited form as: J Psychiatr Res. 2013 Nov; 47(11): 1717–1724. Published online 2013 Aug 13. doi: 10.1016/j.jpsychires.2013.07.013

PMCID:: PMC4286179

Abstract Article PDF–365K

Select item 420684115.

Disease-Targeted Sequencing of Ion Channel Genes identifies de novo mutations in Patients with Non-Familial Brugada Syndrome

Jyh-Ming Jimmy Juang, Tzu-Pin Lu, Liang-Chuan Lai, Chia-Chuan Ho, Yen-Bin Liu, Chia-Ti Tsai, Lian-Yu Lin, Chih-Chieh Yu, Wen-Jone Chen, Fu-Tien Chiang, Shih-Fan Sherri Yeh, Ling-Ping Lai, Eric Y. Chuang, Jiunn-Lee Lin

Sci Rep. 2014; 4: 6733. Published online 2014 Oct 23. doi: 10.1038/srep06733

PMCID:: PMC4206841

Abstract Article PDF–1.4M

Select item 337801916.

Expression and function of K_V2-containing channels in human urinary bladder smooth muscle

Kiril L. Hristov, Muyan Chen, Serge A. Y. Afeli, Qiuping Cheng, Eric S. Rovner, Georgi V. Petkov

Am J Physiol Cell Physiol. 2012 Jun 1; 302(11): C1599–C1608. Published online 2012 Mar 14. doi: 10.1152/ajpcell.00447.2011

PMCID:: PMC3378019

Abstract Article

Select item 329757317.

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

Eimear E. Kenny, Itsik Pe'er, Amir Karban, Laurie Ozelius, Adele A. Mitchell, Sok Meng Ng, Monica Erazo, Harry Ostrer, Clara Abraham, Maria T. Abreu, Gil Atzmon, Nir Barzilai, Steven R. Brant, Susan Bressman, Edward R. Burns, Yehuda Chowers, Lorraine N. Clark, Ariel Darvasi, Dana Doheny, Richard H. Duerr, Rami Eliakim, Nir Giladi, Peter K. Gregersen, Hakon Hakonarson, Michelle R. Jones, Karen Marder, Dermot P. B. McGovern, Jennifer Mulle, Avi Orr-Urtreger, Deborah D. Proctor, Ann Pulver, Jerome I. Rotter, Mark S. Silverberg, Thomas Ullman, Stephen T. Warren, Matti Waterman, Wei Zhang, Aviv Bergman, Lloyd Mayer, Seymour Katz, Robert J. Desnick, Judy H. Cho, Inga Peter

PLoS Genet. 2012 Mar; 8(3): e1002559. Published online 2012 Mar 8. doi: 10.1371/journal.pgen.1002559