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Select item 109256481.

Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant

Yan Wang, Chao Yang, Jun Wen, Lingling Ju, Zhengyun Ren, Tongtong Zhang, Yanjun Liu

Front Endocrinol (Lausanne) 2024; 15: 1334342. Published online 2024 Feb 26. doi: 10.3389/fendo.2024.1334342

PMCID:: PMC10925648

Abstract Article PDF–781K

Select item 109146262.

CaMKK2 as an emerging treatment target for bipolar disorder

Jacqueline Kaiser, Kevin Nay, Christopher R. Horne, Luke M. McAloon, Oliver K. Fuller, Abbey G. Muller, Douglas G. Whyte, Anthony R. Means, Ken Walder, Michael Berk, Anthony J. Hannan, James M. Murphy, Mark A. Febbraio, Andrew L. Gundlach, John W. Scott

Mol Psychiatry. 2023; 28(11): 4500–4511. Published online 2023 Sep 20. doi: 10.1038/s41380-023-02260-3

PMCID:: PMC10914626

Abstract Article PDF–1.2M

Select item 104721103.

Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis

Debarati Mukherjee, Rebecca A. Previs, Corinne Haines, Muthana Al Abo, Patrick K. Juras, Kyle C. Strickland, Binita Chakraborty, Sandeep Artham, Regina S. Whitaker, Katherine Hebert, Jake Fontenot, Steven R. Patierno, Jennifer A. Freedman, Frank H. Lau, Matthew E. Burow, Ching-Yi Chang, Donald P. McDonnell

Cancer Res. 2023 Sep 1; 83(17): 2889–2907. Published online 2023 Jun 19. doi: 10.1158/0008-5472.CAN-22-1622

PMCID:: PMC10472110

Abstract Article PDF–19M

Select item 104042154.

Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy

Jessica Gaff, Fitri Octaviana, Connie Jackaman, Peter Kamerman, John Papadimitriou, Silvia Lee, Jenjira Mountford, Patricia Price

J Neurovirol. 2023; 29(3): 241–251. Published online 2023 May 11. doi: 10.1007/s13365-023-01134-2

PMCID:: PMC10404215

Abstract Article PDF–1.7M

Select item 100729065.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 99879986.

The role of CaMKK2 in Golgi-associated vesicle trafficking

Grace Kennedy, Olivia Gibson, Dáire T. O'Hare, Ian G. Mills, Emma Evergren

Biochem Soc Trans. 2023 Feb 27; 51(1): 331–342. Published online 2023 Feb 23. doi: 10.1042/BST20220833

PMCID:: PMC9987998

Abstract Article PDF–2.3M

Select item 98442537.

Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ

Fan Wu, Kayla Hill, Qiaojun Fang, Zuhong He, Hongwei Zheng, Xianren Wang, Hao Xiong, Su-Hua Sha

Cell Mol Life Sci. 2022 May; 79(5): 249. Published online 2022 Apr 19. doi: 10.1007/s00018-022-04268-4

PMCID:: PMC9844253

Abstract Article PDF–5.4M

Select item 96179498.

Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma

William H. Tomaszewski, Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, Mustafa Khasraw, David M. Ashley, Peter E. Fecci, Luigi Racioppi, Luis Sanchez-Perez, Michael D. Gunn, John H. Sampson

Nat Commun. 2022; 13: 6483. Published online 2022 Oct 29. doi: 10.1038/s41467-022-34175-y

PMCID:: PMC9617949

Abstract Article PDF–8.1M

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 869936010.

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid

Faten Merhi, Karla Alvarez-Valadez, Jenifer Trepiana, Claire Lescoat, Alexis Groppi, Jean-William Dupuy, Pierre Soubeyran, Guido Kroemer, Pierre Vacher, Mojgan Djavaheri-Mergny

Cells. 2021 Dec; 10(12): 3364. Published online 2021 Nov 30. doi: 10.3390/cells10123364

PMCID:: PMC8699360

Abstract Article PDF–3.2M

Select item 856163411.

CARS senses cysteine deprivation to activate AMPK for cell survival

Mengqiu Yuan, Ronghui Yan, Yi Zhang, Yue Qiu, Zetan Jiang, Haiying Liu, Ying Wang, Linchong Sun, Huafeng Zhang, Ping Gao

EMBO J. 2021 Nov 2; 40(21): e108028. Published online 2021 Sep 2. doi: 10.15252/embj.2021108028

PMCID:: PMC8561634

Abstract Article PDF–4.6M

Select item 856077012.

CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation

Lorna M. Stewart, Lisa Gerner, Mandy Rettel, Frank Stein, James F. Burrows, Ian G. Mills, Emma Evergren

Cell Death Dis. 2021 Nov; 12(11): 1040. Published online 2021 Nov 1. doi: 10.1038/s41419-021-04335-x

PMCID:: PMC8560770

Abstract Article PDF–4.7M

Select item 846690813.

CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner

Mohammad Golam Sabbir, Carla G. Taylor, Peter Zahradka

Cell Commun Signal. 2021; 19: 98. Published online 2021 Sep 25. doi: 10.1186/s12964-021-00778-z

PMCID:: PMC8466908

Abstract Article PDF–8.0M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 793576215.

Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling

Chenchu Lin, Alicia M. Blessing, Thomas L. Pulliam, Yan Shi, Sandi R. Wilkenfeld, Jenny J. Han, Mollianne M. Murray, Alexander H. Pham, Kevin Duong, Sonja N. Brun, Reuben J. Shaw, Michael M. Ittmann, Daniel E. Frigo

Oncogene. Author manuscript; available in PMC 2021 Aug 2.

Published in final edited form as: Oncogene. 2021 Mar; 40(9): 1690–1705. Published online 2021 Feb 2. doi: 10.1038/s41388-021-01658-z

PMCID:: PMC7935762

Abstract Article PDF–1.3M

Select item 778549416.

AMPK, a key regulator of metabolism and autophagy, is activated by lysosomal damage via a novel galectin-directed ubiquitin signal transduction system

Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R. Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic

Mol Cell. Author manuscript; available in PMC 2021 Mar 5.

Published in final edited form as: Mol Cell. 2020 Mar 5; 77(5): 951–969.e9. Published online 2020 Jan 28. doi: 10.1016/j.molcel.2019.12.028

PMCID:: PMC7785494

Abstract Article PDF–2.9M

Select item 770530017.

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

Christopher G. Langendorf, Matthew T. O'Brien, Kevin R. W. Ngoei, Luke M. McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi X. Y. Ling, Toby A. Dite, Sandra Galic, Kim Loh, Michael W. Parker, Jonathan S. Oakhill, Bruce E. Kemp, John W. Scott

J Biol Chem. 2020 Nov 27; 295(48): 16239–16250. Published online 2020 Sep 9. doi: 10.1074/jbc.RA120.013756

PMCID:: PMC7705300

Abstract Article PDF–15M

Select item 755922418.

Effects of Single-Nucleotide Polymorphisms in Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2): A Comprehensive Study

Zoya Khalid, Omar Almaghrabi

Comput Math Methods Med. 2020; 2020: 7419512. Published online 2020 Oct 6. doi: 10.1155/2020/7419512

PMCID:: PMC7559224

Abstract Article PDF–2.2M

Select item 742732719.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001