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Select item 82901981.

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events

Nirdosh Dadwal, Charlie Mix, Annegret Reinhold, Amelie Witte, Christian Freund, Burkhart Schraven, Stefanie Kliche

Front Immunol. 2021; 12: 703534. Published online 2021 Jul 6. doi: 10.3389/fimmu.2021.703534

PMCID:: PMC8290198

Abstract Article PDF–1.3M

Select item 82827642.

N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

Yuanming Cheng, Wei Xie, Brian F Pickering, Karen L Chu, Angela M Savino, Xuejing Yang, Hanzhi Luo, Diu TT Nguyen, Shanlan Mo, Ersilia Barin, Anthony Velleca, Thomas Rohwetter, Dinshaw J Patel, Samie R Jaffrey, Michael G Kharas

Cancer Cell. Author manuscript; available in PMC 2022 Jul 12.

Published in final edited form as: Cancer Cell. 2021 Jul 12; 39(7): 958–972.e8. Published online 2021 May 27. doi: 10.1016/j.ccell.2021.04.017

PMCID:: PMC8282764

Abstract Article PDF–3.4M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 63865884.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 62403005.

ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters

Juliana B. Lewis, Frank A. Scangarello, Joanne M. Murphy, Keith P. Eidell, Michelle O. Sodipo, Michael J. Ophir, Ryan Sargeant, Maria-Cristina Seminario, Stephen C. Bunnell

J Cell Sci. 2018 Nov 1; 131(21): jcs215517. Published online 2018 Nov 8. doi: 10.1242/jcs.215517

PMCID:: PMC6240300

Abstract Article

Select item 61666826.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 58625647.

The SRC-family tyrosine kinase HCK shapes the landscape of SKAP2 interactome

Jean-François Bureau, Patricia Cassonnet, Laura Grange, Julien Dessapt, Louis Jones, Caroline Demeret, Anavaj Sakuntabhai, Yves Jacob

Oncotarget. 2018 Mar 2; 9(17): 13102–13115. Published online 2018 Feb 6. doi: 10.18632/oncotarget.24424

PMCID:: PMC5862564

Abstract Article PDF–2.2M

Select item 46380398.

Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration

Benno Kuropka, Amelie Witte, Jana Sticht, Natalie Waldt, Paul Majkut, Christian P. R. Hackenberger, Burkhart Schraven, Eberhard Krause, Stefanie Kliche, Christian Freund

Mol Cell Proteomics. 2015 Nov; 14(11): 2961–2972. Published online 2015 Aug 5. doi: 10.1074/mcp.M115.048249

PMCID:: PMC4638039

Abstract Article PDF–1.5M

Select item 45693139.

Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1

Ana Dios-Esponera, Soledad Isern de Val, Silvia Sevilla-Movilla, Rosa García-Verdugo, David García-Bernal, Nohemí Arellano-Sánchez, Carlos Cabañas, Joaquin Teixidó

Mol Biol Cell. 2015 Sep 15; 26(18): 3215–3228. doi: 10.1091/mbc.E14-07-1246

PMCID:: PMC4569313

Abstract Article PDF–3.4M

Select item 441187010.

Recessive thrombocytopenia likely due to a homozygous pathogenic variant in the FYB gene: case report

Hanan Hamamy, Periklis Makrythanasis, Nasir Al-Allawi, Abdulrahman A Muhsin, Stylianos E Antonarakis

BMC Med Genet. 2014; 15: 135. Published online 2014 Dec 17. doi: 10.1186/s12881-014-0135-0

PMCID:: PMC4411870

Abstract Article PDF–631K

Select item 440912011.

The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection

Chunyang Li, Shaozhuo Jiao, Guojun Wang, Yunzhen Gao, Chang Liu, Xijun He, Chi Zhang, Jun Xiao, Weiyun Li, Guoquan Zhang, Bin Wei, Hualan Chen, Hongyan Wang

PLoS Pathog. 2015 Apr; 11(4): e1004824. Published online 2015 Apr 24. doi: 10.1371/journal.ppat.1004824

PMCID:: PMC4409120

Abstract Article PDF–3.9M

Select item 438092812.

Phospho-tyrosine dependent protein–protein interaction network

Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl

Mol Syst Biol. 2015 Mar; 11(3): 0794. Published online 2015 Mar 26. doi: 10.15252/msb.20145968

PMCID:: PMC4380928

Abstract Article PDF–1.9M

Select item 402342113.

ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding

Ana Kasirer-Friede, Jian Kang, Bryan Kahner, Feng Ye, Mark H. Ginsberg, Sanford J. Shattil

Blood. 2014 May 15; 123(20): 3156–3165. Prepublished online 2014 Feb 12. doi: 10.1182/blood-2013-08-520627

PMCID:: PMC4023421

Abstract Article

Select item 385170914.

Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors

Bin Wei, Lei Han, Truus E M Abbink, Elisabetta Groppelli, Daina Lim, Youg Raj Thaker, Wei Gao, Rongrong Zhai, Jianhua Wang, Andrew Lever, Clare Jolly, Hongyan Wang, Christopher E Rudd

Retrovirology. 2013; 10: 101. Published online 2013 Sep 18. doi: 10.1186/1742-4690-10-101

PMCID:: PMC3851709

Abstract Article PDF–2.9M

Select item 381188715.

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

Nathan P. Coussens, Ryo Hayashi, Patrick H. Brown, Lakshmi Balagopalan, Andrea Balbo, Itoro Akpan, Jon C. D. Houtman, Valarie A. Barr, Peter Schuck, Ettore Appella, Lawrence E. Samelson

Mol Cell Biol. 2013 Nov; 33(21): 4140–4151. doi: 10.1128/MCB.00410-13