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Items: 1 to 20 of 124

1.
Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells
Nikhil Ponnoor Anto, Awadhesh Kumar Arya, Amitha Muraleedharan, Jakeer Shaik, Pulak Ranjan Nath, Etta Livneh, Zuoming Sun, Alex Braiman, Noah Isakov
Cell Mol Life Sci. 2023 Jan; 80(1): 7. Published online 2022 Dec 10. doi: 10.1007/s00018-022-04657-9
PMCID:
PMC11072327
AbstractArticlePDF–3.1M
2.
Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain
Cédric Mongellaz, Rita Vicente, Lenora M. Noroski, Nelly Noraz, Valérie Courgnaud, Javier Chinen, Emilia Faria, Valérie S. Zimmermann, Naomi Taylor
Front Immunol. 2023; 14: 1155883. Published online 2023 May 29. doi: 10.3389/fimmu.2023.1155883
PMCID:
PMC10258307
AbstractArticlePDF–12M
3.
A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
Annika Schultz, Marvin Schnurra, Ali El-Bizri, Nadine M. Woessner, Sara Hartmann, Roland Hartig, Susana Minguet, Burkhart Schraven, Luca Simeoni
Cells. 2022 Sep; 11(17): 2723. Published online 2022 Sep 1. doi: 10.3390/cells11172723
PMCID:
PMC9455082
AbstractArticlePDF–1.7M
4.
AQP9 and ZAP70 as immune-related prognostic biomarkers suppress proliferation, migration and invasion of laryngeal cancer cells
Li Ren, Ping Li, Zhouping Li, Quan Chen
BMC Cancer. 2022; 22: 465. Published online 2022 Apr 28. doi: 10.1186/s12885-022-09458-8
PMCID:
PMC9047300
AbstractArticlePDF–12M
5.
Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
Jesse Goyette, David Depoil, Zhengmin Yang, Samuel A. Isaacson, Jun Allard, P. Anton van der Merwe, Katharina Gaus, Michael L. Dustin, Omer Dushek
Proc Natl Acad Sci U S A. 2022 Mar 1; 119(9): e2116815119. Published online 2022 Feb 23. doi: 10.1073/pnas.2116815119
PMCID:
PMC8892339
AbstractArticlePDF–2.3M
6.
T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival
Sanjay de Mel, Nurulhuda Mustafa, Viknesvaran Selvarajan, Muhammad Irfan Azaman, Patrick William Jaynes, Shruthi Venguidessane, Hoang Mai Phuong, Zubaida Talal Alnaseri, The Phyu, Louis-Pierre Girard, Wee Joo Chng, Joanna Wardyn, Ying Li, Omer An, Henry Yang, Siok Bian Ng, Anand D. Jeyasekharan
PLoS One. 2022; 17(1): e0261469. Published online 2022 Jan 25. doi: 10.1371/journal.pone.0261469
PMCID:
PMC8789098
AbstractArticlePDF–1.8M
7.
The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling
Mobashar Hussain Urf Turabe Fazil, Chandra Sekhar Chirumamilla, Claudina Perez-Novo, Brandon Han Siang Wong, Sunil Kumar, Siu Kwan Sze, Wim Vanden Berghe, Navin Kumar Verma
J Biol Chem. 2021 Dec; 297(6): 101377. Published online 2021 Nov 3. doi: 10.1016/j.jbc.2021.101377
PMCID:
PMC8637146
AbstractArticlePDF–4.8M
8.
Differences in the dynamics of the tandem‐SH2 modules of the Syk and ZAP‐70 tyrosine kinases
Helen T. Hobbs, Neel H. Shah, Jean M. Badroos, Christine L. Gee, Susan Marqusee, John Kuriyan
Protein Sci. 2021 Dec; 30(12): 2373–2384. Published online 2021 Oct 23. doi: 10.1002/pro.4199
PMCID:
PMC8605373
AbstractArticlePDF–5.8M
9.
TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection
Yongjian Wu, Minhao Wu, Siqi Ming, Xiaoxia Zhan, Shengfeng Hu, Xingyu Li, Huan Yin, Can Cao, Jiao Liu, Jinai Li, Zhilong Wu, Jie Zhou, Lei Liu, Sitang Gong, Duanman He, Xi Huang
J Clin Invest. 2021 Sep 1; 131(17): e137407. Published online 2021 Sep 1. doi: 10.1172/JCI137407
PMCID:
PMC8409584
AbstractArticlePDF–12M
10.
Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse
Bonah Kim, Hee Young Kim, Won-Woo Lee
Front Immunol. 2021; 12: 687367. Published online 2021 Jul 29. doi: 10.3389/fimmu.2021.687367
PMCID:
PMC8358678
AbstractArticlePDF–8.7M
11.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
12.
Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling
Kelsey Kaman, Monique Abrams, Kerry Dobbs, Luigi D. Notarangelo, Ottavia M. Delmonte, Boaz Palterer, Sung-Yun Pai, Alicia Johnston
J Clin Immunol. Author manuscript; available in PMC 2021 Aug 1.
Published in final edited form as: J Clin Immunol. 2021 Feb; 41(2): 470–472. Published online 2020 Nov 13. doi: 10.1007/s10875-020-00913-4
PMCID:
PMC8319789
ArticlePDF–403K
13.
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer
Teresa Sadras, Mickaël Martin, Kohei Kume, Mark E. Robinson, Supraja Saravanakumar, Gal Lenz, Zhengshan Chen, Joo Y. Song, Tanya Siddiqi, Laura Oksa, Anne Marie Knapp, Jevon Cutler, Kadriye Nehir Cosgun, Lars Klemm, Veronika Ecker, Janet Winchester, Dana Ghergus, Pauline Soulas-Sprauel, Friedemann Kiefer, Nora Heisterkamp, Akhilesh Pandey, Vu Ngo, Lili Wang, Hassan Jumaa, Maike Buchner, Jürgen Ruland, Wing-Chung Chan, Eric Meffre, Thierry Martin, Markus Müschen
Mol Cell. Author manuscript; available in PMC 2022 May 20.
Published in final edited form as: Mol Cell. 2021 May 20; 81(10): 2094–2111.e9. Published online 2021 Apr 19. doi: 10.1016/j.molcel.2021.03.043
PMCID:
PMC8239336
AbstractArticlePDF–3.6M
14.
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self ligands
Lin Shen, Mehrdad Matloubian, Theresa A. Kadlecek, Arthur Weiss
Sci Signal. Author manuscript; available in PMC 2021 Aug 2.
Published in final edited form as: Sci Signal. 2021 Feb 2; 14(668): eabc4479. Published online 2021 Feb 2. doi: 10.1126/scisignal.abc4479
PMCID:
PMC8009134
AbstractArticlePDF–2.0M
15.
T cell receptor–dependent S-acylation of ZAP-70 controls activation of T cells
Ritika Tewari, Bieerkehazhi Shayahati, Ying Fan, Askar M. Akimzhanov
J Biol Chem. 2021 Jan-Jun; 296: 100311. Published online 2021 Jan 19. doi: 10.1016/j.jbc.2021.100311
PMCID:
PMC7949058
AbstractArticlePDF–1.2M
16.
Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer
Hantao Wang, Junjie Xing, Wei Wang, Guifen Lv, Haiyan He, Yeqing Lu, Mei Sun, Haiyan Chen, Xu Li
Front Cell Dev Biol. 2020; 8: 601502. Published online 2021 Feb 11. doi: 10.3389/fcell.2020.601502
PMCID:
PMC7905040
AbstractArticlePDF–3.2M
17.
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
Jesse E. Jun, Kayla R. Kulhanek, Hang Chen, Arup Chakraborty, Jeroen P. Roose
Sci Signal. Author manuscript; available in PMC 2020 Jul 7.
Published in final edited form as: Sci Signal. 2019 Jul 23; 12(591): eaao0736. Published online 2019 Jul 23. doi: 10.1126/scisignal.aao0736
PMCID:
PMC7340343
AbstractArticlePDF–2.4M
18.
Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review
Niusha Sharifinejad, Mahnaz Jamee, Majid Zaki-Dizaji, Bernice Lo, Mohammadreza Shaghaghi, Hamed Mohammadi, Farhad Jadidi-Niaragh, Shiva Shaghaghi, Reza Yazdani, Hassan Abolhassani, Asghar Aghamohammadi, Gholamreza Azizi
Front Immunol. 2020; 11: 831. Published online 2020 May 5. doi: 10.3389/fimmu.2020.00831
PMCID:
PMC7214800
AbstractArticlePDF–704K
19.
Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling
Jiji Xie, Xuemei Han, Chensi Zhao, Ann J. Canonigo-Balancio, John R. Yates, III, Yingqiu Li, Björn F. Lillemeier, Amnon Altman
Sci Signal. Author manuscript; available in PMC 2020 May 2.
Published in final edited form as: Sci Signal. 2019 Apr 16; 12(577): eaar3349. Published online 2019 Apr 16. doi: 10.1126/scisignal.aar3349
PMCID:
PMC7195849
AbstractArticlePDF–2.0M
20.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch
Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9
PMCID:
PMC6981206
AbstractArticlePDF–3.7M

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