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Select item 103868871.

K_ATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer’s disease–related pathology

John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, James A. Snipes, Derek Kellar, Emily E. Caesar, Ryan J. Pettit-Mee, Stephen M. Day, Jonathon P. Sens, Noelle I. Nicol, Jasmeen Dhillon, Maria S. Remedi, Drew D. Kiraly, Celeste M. Karch, Colin G. Nichols, David M. Holtzman, Shannon L. Macauley

JCI Insight. 2023 May 22; 8(10): e162454. Published online 2023 May 22. doi: 10.1172/jci.insight.162454

PMCID:: PMC10386887

Abstract Article PDF–6.2M

Select item 101948232.

Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with K_ATP channel gain-of-function

Michael J Davis, Jorge A Castorena-Gonzalez, Hae Jin Kim, Min Li, Maria Remedi, Colin G Nichols

Function (Oxf) 2023; 4(3): zqad017. Published online 2023 Apr 18. doi: 10.1093/function/zqad017

PMCID:: PMC10194823

Abstract Article PDF–5.1M

Select item 97979593.

Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels

Cristiana Bercea, Roshan Limbu, Kamila Behnam, Keat-Eng Ng, Qadeer Aziz, Andrew Tinker, Francesco Tamagnini, Graeme S Cottrell, Alister J McNeish

Front Physiol. 2022; 13: 1033216. Published online 2022 Dec 15. doi: 10.3389/fphys.2022.1033216

PMCID:: PMC9797959

Abstract Article PDF–1.6M

Select item 85672274.

Single‐cell transcriptomic landscape of cardiac neural crest cell derivatives during development

Wen Chen, Xuanyu Liu, Wenke Li, Huayan Shen, Ziyi Zeng, Kunlun Yin, James R Priest, Zhou Zhou

EMBO Rep. 2021 Nov 4; 22(11): e52389. Published online 2021 Sep 27. doi: 10.15252/embr.202152389

PMCID:: PMC8567227

Abstract Article PDF–4.6M

Select item 77343375.

Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome

Rosa Scala, Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Giulia Maria Camerino, Francesco Alfredo Zito, Girolamo Ranieri, Conor McClenaghan, Theresa M. Harter, Colin G. Nichols, Domenico Tricarico

Front Pharmacol. 2020; 11: 604885. Published online 2020 Nov 30. doi: 10.3389/fphar.2020.604885

PMCID:: PMC7734337

Abstract Article PDF–2.7M

Select item 77144096.

Kir6.1- and SUR2-dependent K_ATP overactivity disrupts intestinal motility in murine models of Cantú syndrome

Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols

JCI Insight. 2020 Dec 3; 5(23): e141443. Published online 2020 Nov 10. doi: 10.1172/jci.insight.141443

PMCID:: PMC7714409

Abstract Article PDF–11M

Select item 73996917.

Vascular K_ATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia

Qadeer Aziz, Jianmin Chen, Amie J Moyes, Yiwen Li, Naomi A Anderson, Richard Ang, Dunja Aksentijevic, Sonia Sebastian, Adrian J Hobbs, Christoph Thiemermann, Andrew Tinker

J Mol Med (Berl) 2020; 98(8): 1149–1160. Published online 2020 Jul 6. doi: 10.1007/s00109-020-01946-3

PMCID:: PMC7399691

Abstract Article PDF–2.0M

Select item 72695888.

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by K_ATP channel overactivity

Conor McClenaghan, Yan Huang, Zihan Yan, Theresa M. Harter, Carmen M. Halabi, Rod Chalk, Attila Kovacs, Gijs van Haaften, Maria S. Remedi, Colin G. Nichols

J Clin Invest. 2020 Mar 2; 130(3): 1116–1121. Published online 2020 Feb 17. doi: 10.1172/JCI130571

PMCID:: PMC7269588

Abstract Article PDF–1.1M

Select item 69273329.

Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate–sensitive potassium channel subunit Kir6.1

Matthew C. Henn, M. Burhan Janjua, Haixia Zhang, Evelyn M. Kanter, Carol M. Makepeace, Richard B. Schuessler, Colin G. Nichols, Jennifer S. Lawton

J Surg Res. Author manuscript; available in PMC 2019 Dec 23.

Published in final edited form as: J Surg Res. 2016 Dec; 206(2): 460–465. Published online 2016 Aug 12. doi: 10.1016/j.jss.2016.08.043

PMCID:: PMC6927332

Abstract Article PDF–841K

Select item 680264310.

The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3

Ren-Hong Du, Ming Lu, Cong Wang, Jian-Hua Ding, Guangyu Wu, Gang Hu

Exp Mol Med. 2019 Aug; 51(8): 1–13. Published online 2019 Aug 6. doi: 10.1038/s12276-019-0291-6

PMCID:: PMC6802643

Abstract Article PDF–1.4M

Select item 677559011.

A critical role for the ATP-sensitive potassium channel subunit K_IR6.1 in the control of cerebral blood flow

Patrick S Hosford, Isabel N Christie, Arun Niranjan, Qadeer Aziz, Naomi Anderson, Richard Ang, Mark F Lythgoe, Jack A Wells, Andrew Tinker, Alexander V Gourine

J Cereb Blood Flow Metab. 2019 Oct; 39(10): 2089–2095. Published online 2018 Jun 4. doi: 10.1177/0271678X18780602

PMCID:: PMC6775590

Abstract Article PDF–450K

Select item 649337912.

Iptakalim Enhances Adult Mouse Hippocampal Neurogenesis Via Opening Kir6.1‐Composed K‐ATP Channels Expressed in Neural Stem Cells

Jing‐Zhe Yang, Xu Huang, Fang‐Fang Zhao, Qiang Xu, Gang Hu

CNS Neurosci Ther. 2012 Sep; 18(9): 737–744. Published online 2012 Jun 28. doi: 10.1111/j.1755-5949.2012.00359.x

PMCID:: PMC6493379

Abstract Article PDF–351K

Select item 649334213.

Kir6.1 Knockdown Aggravates Cerebral Ischemia/Reperfusion‐Induced Neural Injury in Mice

Yin‐Feng Dong, Lin‐Xiao Wang, Xu Huang, Wen‐Jing Cao, Ming Lu, Jian‐Hua Ding, Xiu‐Lan Sun, Gang Hu

CNS Neurosci Ther. 2013 Aug; 19(8): 617–624. Published online 2013 May 11. doi: 10.1111/cns.12117

PMCID:: PMC6493342

Abstract Article PDF–530K

Select item 632983114.

Single-cell transcriptomic analysis of mouse neocortical development

Lipin Loo, Jeremy M. Simon, Lei Xing, Eric S. McCoy, Jesse K. Niehaus, Jiami Guo, E. S. Anton, Mark J. Zylka

Nat Commun. 2019; 10: 134. Published online 2019 Jan 11. doi: 10.1038/s41467-018-08079-9

PMCID:: PMC6329831

Abstract Article PDF–3.6M

Select item 612911715.

Cardiovascular consequences of K_ATP overactivity in Cantu syndrome

Yan Huang, Conor McClenaghan, Theresa M. Harter, Kristina Hinman, Carmen M. Halabi, Scot J. Matkovich, Haixia Zhang, G. Schuyler Brown, Robert P. Mecham, Sarah K. England, Attila Kovacs, Maria S. Remedi, Colin G. Nichols

JCI Insight. 2018 Aug 9; 3(15): e121153. Published online 2018 Aug 9. doi: 10.1172/jci.insight.121153