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Select item 108246701.

In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex

Niina K. Hassi, Timir Weston, Giulia Rinaldi, Joseph C. Ng, Asma Smahi, Sophie Twelves, Camilla Davan-Wetton, Dana Fakhreddine, Franca Fraternali, Francesca Capon

J Invest Dermatol. 2023 Dec; 143(12): 2468–2475.e6. doi: 10.1016/j.jid.2023.06.191

PMCID:: PMC10824670

Abstract Article

Select item 93146462.

IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic

Hongna Dong, Yuqiu Hao, Wei Li, Wei Yang, Peng Gao

Front Immunol. 2022; 13: 921275. Published online 2022 Jul 12. doi: 10.3389/fimmu.2022.921275

PMCID:: PMC9314646

Abstract Article PDF–1.7M

Select item 84988823.

IL‐36γ and IL‐36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress‐Induced Cell Death

Peng Wang, Wei Yang, Hao Guo, Hong‐Peng Dong, Yu‐Yao Guo, Hu Gan, Zou Wang, Yongbo Cheng, Yu Deng, Shizhe Xie, Xinglou Yang, Dandan Lin, Bo Zhong

Adv Sci (Weinh) 2021 Oct; 8(19): 2101501. Published online 2021 Aug 8. doi: 10.1002/advs.202101501

PMCID:: PMC8498882

Abstract Article PDF–11M

Select item 84185024.

Down‐regulated IL36RN expression based on peripheral blood mononuclear cells and plasma of periodontitis patients and its clinical significance

Yue Zhou, Yufu Liang

J Clin Lab Anal. 2021 Sep; 35(9): e23899. Published online 2021 Jul 17. doi: 10.1002/jcla.23899

PMCID:: PMC8418502

Abstract Article PDF–1.4M

Select item 82359155.

SARS-CoV-2 infection inducing severe flare up of Deficiency of Interleukin Thirty-six (IL-36) Receptor Antagonist (DITRA) resulting from a mutation invalidating the activating cleavage site of the IL-36 receptor antagonist

Alizée Bozonnat, Florence Assan, Jérôme LeGoff, Emmanuelle Bourrat, Hervé Bachelez

J Clin Immunol. 2021; 41(7): 1511–1514. Published online 2021 Jun 26. doi: 10.1007/s10875-021-01076-6

PMCID:: PMC8235915

Article PDF–846K

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76475327.

Association between mutation of interleukin 36 receptor antagonist and generalized pustular psoriasis: A PRISMA-compliant systematic review and meta-analysis

Zhi-Jie Liu, Yu-Tong Tian, Bo-Yi Shi, Yin Zhou, Xue-Song Jia

Medicine (Baltimore) 2020 Nov 6; 99(45): e23068. Published online 2020 Nov 6. doi: 10.1097/MD.0000000000023068

PMCID:: PMC7647532

Abstract Article PDF–579K

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 70978489.

IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis

Marika Catapano, Marta Vergnano, Marco Romano, Satveer K. Mahil, Siew-Eng Choon, A. David Burden, Helen S. Young, Ian M. Carr, Helen J. Lachmann, Giovanna Lombardi, Catherine H. Smith, Francesca D. Ciccarelli, Jonathan N. Barker, Francesca Capon

J Invest Dermatol. 2020 Apr; 140(4): 816–826.e3. doi: 10.1016/j.jid.2019.08.444

PMCID:: PMC7097848

Abstract Article

Select item 693919010.

Lack of association between mutation in IL36RN and palmoplantar pustular psoriasis in Chinese patients

Yu Xiaoling, Shu Dan, Jin Hongzhong

An Bras Dermatol. 2019 Nov-Dec; 94(6): 658–663. Published online 2019 Oct 26. doi: 10.1016/j.abd.2019.01.008

PMCID:: PMC6939190

Abstract Article PDF–1.1M

Select item 608117311.

Genetic polymorphism of IL36RN in Han patients with generalized pustular psoriasis in Sichuan region of China: A case–control study

Zhongtao Li, Qianyi Yang, Sheng Wang

Medicine (Baltimore) 2018 Aug; 97(31): e11741. Published online 2018 Aug 3. doi: 10.1097/MD.0000000000011741

PMCID:: PMC6081173

Abstract Article PDF–190K

Select item 553161112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 525879913.

Mutations in IL36RN are associated with geographic tongue

Jianying Liang, Peichen Huang, Huaguo Li, Jia Zhang, Cheng Ni, Yirong Wang, Jinwen Shen, Chunxiao Li, Lu Kang, Jie Chen, Hui Zhang, Zhen Wang, Zhen Zhang, Ming Li, Zhirong Yao

Hum Genet. 2017; 136(2): 241–252. Published online 2016 Nov 29. doi: 10.1007/s00439-016-1750-y

PMCID:: PMC5258799

Abstract Article PDF–1.5M

Select item 497368414.

A novel mutation in IL36RN underpins childhood pustular dermatosis

J.M. Ellingford, G.C.M. Black, T.H. Clayton, M. Judge, C.E.M. Griffiths, R.B. Warren

J Eur Acad Dermatol Venereol. 2016 Feb; 30(2): 302–305. Published online 2015 Feb 16. doi: 10.1111/jdv.13034

PMCID:: PMC4973684

Abstract Article PDF–375K

Select item 484036215.

Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist

Tom Macleod, Rosella Doble, Dennis McGonagle, Christopher W. Wasson, Adewonuola Alase, Martin Stacey, Miriam Wittmann

Sci Rep. 2016; 6: 24880. Published online 2016 Apr 22. doi: 10.1038/srep24880

PMCID:: PMC4840362

Abstract Article PDF–542K

Select item 476254016.

A tale of two sisters: identical IL36RN mutations and discordant phenotypes

N. Rajan, N. Sinclair, H. Nakai, Y. Shimomura, S. Natarajan

Br J Dermatol. 2016 Feb; 174(2): 417–420. Published online 2015 Nov 25. doi: 10.1111/bjd.14003

PMCID:: PMC4762540

Article PDF–827K

Select item 440586417.

Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN

Maris Keermann, Sulev Kõks, Ene Reimann, Ele Prans, Kristi Abram, Külli Kingo

BMC Genomics. 2015; 16(1): 322. Published online 2015 Apr 19. doi: 10.1186/s12864-015-1508-2

PMCID:: PMC4405864

Abstract Article PDF–671K

Select item 426658818.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 404878819.

IL-36 promotes myeloid cell infiltration, activation and inflammatory activity in skin

Alexander M. Foster, Jaymie Baliwag, Cynthia S. Chen, Andrew M. Guzman, Stefan W. Stoll, Johann E. Gudjonsson, Nicole L. Ward, Andrew Johnston

J Immunol. Author manuscript; available in PMC 2015 Jun 15.

Published in final edited form as: J Immunol. 2014 Jun 15; 192(12): 6053–6061. Published online 2014 May 14. doi: 10.4049/jimmunol.1301481

PMCID:: PMC4048788

Abstract Article PDF–1.4M

Select item 328695020.

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

Frank L. van de Veerdonk, Angela K. Stoeckman, Gouping Wu, Aaron N. Boeckermann, Tania Azam, Mihai G. Netea, Leo A. B. Joosten, Jos W. M. van der Meer, Ruyi Hao, Vassili Kalabokis, Charles A. Dinarello

Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8): 3001–3005. Published online 2012 Feb 6. doi: 10.1073/pnas.1121534109

PMCID:: PMC3286950

Abstract Article PDF–148K

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