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Items: 1 to 20 of 43

1.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
2.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
3.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
4.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis
Artem Kalinichenko, Giovanna Perinetti Casoni, Loïc Dupré, Luca Trotta, Jakob Huemer, Donatella Galgano, Yolla German, Ben Haladik, Julia Pazmandi, Marini Thian, Özlem Yüce Petronczki, Samuel C. Chiang, Mervi Taskinen, Anne Hekkala, Saila Kauppila, Outi Lindgren, Terhi Tapiainen, Michael J. Kraakman, Kim Vettenranta, Alexis J. Lomakin, Janna Saarela, Mikko R. J. Seppänen, Yenan T. Bryceson, Kaan Boztug
Blood. 2021 Apr 15; 137(15): 2033–2045. Prepublished online 2021 Jan 29. doi: 10.1182/blood.2020008738
PMCID:
PMC8057258
AbstractArticle
7.
Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms
Hui Luo, Dan Liu, Wenbing Liu, Gaoxiang Wang, Liting Chen, Yang Cao, Jia Wei, Min Xiao, Xin Liu, Gang Huang, Wei Wang, Jianfeng Zhou, Qian-fei Wang
Eur J Hum Genet. 2021 Aug; 29(8): 1312–1315. Published online 2021 Apr 19. doi: 10.1038/s41431-021-00886-x
PMCID:
PMC8053565
AbstractArticlePDF–626K
8.
Unc-13 homolog D mediates an antiviral effect of the chromosome 19 microRNA cluster miR-517a
Kamil Krawczynski, Yingshi Ouyang, Jean-Francois Mouillet, Tianjiao Chu, Carolyn B. Coyne, Yoel Sadovsky
J Cell Sci. 2020 Mar 1; 134(5): jcs246769. Published online 2020 Nov 19. doi: 10.1242/jcs.246769
PMCID:
PMC7687871
AbstractArticle
9.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
10.
Lentiviral Gene Therapy for Familial Hemophagocytic Lymphohistiocytosis Type 3, Caused by UNC13D Genetic Defects
Sarah E. Takushi, Na Yoon Paik, Andrew Fedanov, Chengyu Prince, Christopher B. Doering, H. Trent Spencer, Shanmuganathan Chandrakasan
Hum Gene Ther. June 2020; 31(11-12): 626–638. Published online 2020 Jun 12. doi: 10.1089/hum.2019.329
PMCID:
PMC7310202
AbstractArticlePDF–920K
11.
Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets
Donatella Galgano, Tayebeh Soheili, Matthias Voss, Lamberto Torralba-Raga, Bianca Tesi, Frank Cichocki, Isabelle Andre, Jens Rettig, Marina Cavazzana, Yenan Bryceson
Front Immunol. 2020; 11: 1154. Published online 2020 Jun 9. doi: 10.3389/fimmu.2020.01154
PMCID:
PMC7296141
AbstractArticlePDF–2.3M
12.
Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency
Jinzhong Zhang, Jing He, Jennifer L. Johnson, Gennaro Napolitano, Mahalakshmi Ramadass, Farhana Rahman, Sergio D. Catz
Autophagy. 2019; 15(10): 1738–1756. Published online 2019 Apr 5. doi: 10.1080/15548627.2019.1596475
PMCID:
PMC6735675
AbstractArticlePDF–6.5M
13.
Haploinsufficiency of UNC13D increases the risk of lymphoma
Alexandra Löfstedt, Clas Ahlm, Bianca Tesi, Ingvar A. Bergdahl, Magnus Nordenskjöld, Yenan T. Bryceson, Jan‐Inge Henter, Marie Meeths
Cancer. 2019 Jun 1; 125(11): 1848–1854. Published online 2019 Feb 13. doi: 10.1002/cncr.32011
PMCID:
PMC6593970
AbstractArticlePDF–172K
14.
Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases
Sanjeev Kiran Gotru, Johanna P. van Geffen, Magdolna Nagy, Elmina Mammadova-Bach, Julia Eilenberger, Julia Volz, Georgi Manukjan, Harald Schulze, Leonard Wagner, Stefan Eber, Christian Schambeck, Carsten Deppermann, Sanne Brouns, Paquita Nurden, Andreas Greinacher, Ulrich Sachs, Bernhard Nieswandt, Heike M. Hermanns, Johan W. M. Heemskerk, Attila Braun
Sci Rep. 2019; 9: 8333. Published online 2019 Jun 6. doi: 10.1038/s41598-019-44751-w
PMCID:
PMC6554314
AbstractArticlePDF–1.1M
15.
A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4
Scott W. Messenger, Sang Su Woo, Zhongze Sun, Thomas F.J. Martin
J Cell Biol. 2018 Aug 6; 217(8): 2877–2890. doi: 10.1083/jcb.201710132
Correction in:
J Cell Biol. 2019 Apr 1; 218(4): 1423.
PMCID:
PMC6080937
AbstractArticlePDF–2.1M
16.
Identification of a novel nonsense mutation in the UNC13D gene from a patient with hemophagocytic lymphohistiocytosis: a case report
Xijiang Hu, Dongling Liu, Xiwen Jiang, Bo Gao, Changying Chen
BMC Med Genet. 2018; 19: 82. Published online 2018 May 21. doi: 10.1186/s12881-018-0600-2
PMCID:
PMC5963187
AbstractArticlePDF–1.3M
17.
A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel–Palade body exocytosis in endothelial cells
Tarek Chehab, Nina Criado Santos, Anna Holthenrich, Sophia N. Koerdt, Jennifer Disse, Christian Schuberth, Ali Reza Nazmi, Maaike Neeft, Henriette Koch, Kwun Nok M. Man, Sonja M. Wojcik, Thomas F. J. Martin, Peter van der Sluijs, Nils Brose, Volker Gerke
Mol Biol Cell. 2017 Jun 15; 28(12): 1688–1700. doi: 10.1091/mbc.E17-02-0128
PMCID:
PMC5469611
AbstractArticlePDF–3.6M
18.
Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion
Michael C. Chicka, Qiansheng Ren, David Richards, Lance M. Hellman, Jinchao Zhang, Michael G. Fried, Sidney W. Whiteheart
Biochem J. Author manuscript; available in PMC 2017 May 27.
Published in final edited form as: Biochem J. 2016 Mar 1; 473(5): 627–639. Published online 2015 Dec 4. doi: 10.1042/BJ20151150
PMCID:
PMC5446777
AbstractArticlePDF–838K
19.
Panorama of ancient metazoan macromolecular complexes
Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili
Nature. Author manuscript; available in PMC 2016 Sep 26.
Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877
PMCID:
PMC5036527
AbstractArticlePDF–4.7M
20.
Novel Rab27a mutation binds melanophilin, but not Munc13-4 causing immunodeficiency without albinism
Petra Netter, Sanny K. Chan, Pinaki P. Banerjee, Linda Monaco-Shawver, Lenora M. Noroski, Imelda C. Hanson, Lisa R. Forbes, Emily M. Mace, Javier Chinen, H. Bobby Gaspar, Patrick Sleiman, Hakon Hakonarson, Christoph Klein, Mohammad S. Ehlayel, Jordan S. Orange
J Allergy Clin Immunol. Author manuscript; available in PMC 2017 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Aug; 138(2): 599–601.e3. Published online 2016 Mar 23. doi: 10.1016/j.jaci.2015.12.1337
PMCID:
PMC4976026
ArticlePDF–403K

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