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Select item 111706671.

Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons

Afra Aabdien, Laura Sichlinger, Zoe Borgel, Madeleine R. Jones, Iain A. Waston, Nicholas J. F. Gatford, Pooja Raval, Lloyd Tanangonan, Timothy R. Powell, Rodrigo R. R. Duarte, Deepak P. Srivastava

Eur J Neurosci. 2024 Apr; 59(8): 2102–2117. Published online 2024 Jan 26. doi: 10.1111/ejn.16254

PMCID:: PMC11170667

Abstract Article PDF–6.5M

Select item 105658762.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 95236454.

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang, Zhe Han

Commun Biol. 2022; 5: 1039. Published online 2022 Sep 30. doi: 10.1038/s42003-022-03986-6

PMCID:: PMC9523645

Abstract Article PDF–3.9M

Select item 94650285.

TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I

Xiaowei Fei, Xiuquan Wu, Ya-Nan Dou, Kai Sun, Qingdong Guo, Lei Zhang, Sanzhong Li, Jialiang Wei, Yu Huan, Xin He, Zhou Fei

Mol Ther Oncolytics. 2022 Sep 15; 26: 413–428. Published online 2022 Aug 25. doi: 10.1016/j.omto.2022.08.007

PMCID:: PMC9465028

Abstract Article PDF–7.2M

Select item 92792856.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 90588367.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 89206518.

Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants

Hong Mei, Baoming Yin, Wenhong Yang, Jingli Zhang, Hongyan Lu, Xiaobin Qi, Wenhua Mei, Hongzhong Zhang, Jianduan Zhang

Biomed Res Int. 2022; 2022: 1499454. Published online 2022 Mar 7. doi: 10.1155/2022/1499454

PMCID:: PMC8920651

Abstract Article PDF–470K

Select item 88970229.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 885704910.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy, Jesus Madero-Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konrad, Michael E. Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q. Trojanowski, Virginia M.Y. Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J. Krogan, Daniel H. Geschwind, Li Gan

Cell. Author manuscript; available in PMC 2022 Feb 19.

Published in final edited form as: Cell. 2022 Feb 17; 185(4): 712–728.e14. Published online 2022 Jan 20. doi: 10.1016/j.cell.2021.12.041

PMCID:: PMC8857049

Abstract Article PDF–3.6M

Select item 882889511.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 858134012.

NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells

Shinpei Somazu, Yoichi Tanaka, Minori Tamai, Atsushi Watanabe, Keiko Kagami, Masako Abe, Daisuke Harama, Tamao Shinohara, Koshi Akahane, Kumiko Goi, Kanji Sugita, Takaya Moriyama, Jun Yang, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Junko Takita, Takeshi Inukai

J Cell Mol Med. 2021 Nov; 25(22): 10521–10533. Published online 2021 Oct 12. doi: 10.1111/jcmm.16981

PMCID:: PMC8581340

Abstract Article PDF–1.5M

Select item 831454713.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 826895414.

Cytosolic 5′-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway

Rossana Pesi, Simone Allegrini, Mercedes Garcia-Gil, Lucia Piazza, Roberta Moschini, Lars Petter Jordheim, Marcella Camici, Maria Grazia Tozzi

Int J Mol Sci. 2021 Jul; 22(13): 7004. Published online 2021 Jun 29. doi: 10.3390/ijms22137004

PMCID:: PMC8268954

Abstract Article PDF–3.0M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 808174016.

Effects of NT5C2 germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemia

Chuang Jiang, Wenjian Yang, Takaya Moriyama, Chengcheng Liu, Colton Smith, Wentao Yang, Maoxiang Qian, Ziping Li, Morten Tulstrup, Kjeld Schmiegelow, Kristine R. Crews, Hui Zhang, Ching-Hon Pui, William Evans, Mary Relling, Smita Bhatia, Jun J. YangP

Clin Pharmacol Ther. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Clin Pharmacol Ther. 2021 Jun; 109(6): 1538–1545. Published online 2020 Nov 24. doi: 10.1002/cpt.2095

PMCID:: PMC8081740

Abstract Article PDF–716K

Select item 799307617.

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

Jin-Gu Lee, Weiliang Huang, Hangnoh Lee, Joyce van de Leemput, Maureen A. Kane, Zhe Han

Cell Biosci. 2021; 11: 58. Published online 2021 Mar 25. doi: 10.1186/s13578-021-00568-7

PMCID:: PMC7993076

Abstract Article PDF–2.0M

Select item 796884418.

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

Eun Myoung Shin, Vinh Thang Huynh, Sultan Abda Neja, Chia Yi Liu, Anandhkumar Raju, Kelly Tan, Nguan Soon Tan, Jayantha Gunaratne, Xuezhi Bi, Lakshminarayan M. Iyer, L. Aravind, Vinay Tergaonkar

Sci Adv. 2021 Mar; 7(12): eabe2470. Published online 2021 Mar 17. doi: 10.1126/sciadv.abe2470

PMCID:: PMC7968844

Abstract Article PDF–1.1M

Select item 756688119.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 752756220.

NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes

Yng-Tay Chen, Wei-De Lin, Wen-Ling Liao, Ya-Ching Tsai, Jiunn-Wang Liao, Fuu-Jen Tsai

Sci Rep. 2020; 10: 16087. Published online 2020 Sep 30. doi: 10.1038/s41598-020-71336-9

Correction in:: Sci Rep. 2021; 11: 6961.

PMCID:: PMC7527562

Abstract Article PDF–1.6M

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