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Select item 110762831.

YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway

Yue Shi, Yue Cheng, Wei Wang, Liu Tang, Wensheng Li, Liyuan Zhang, Zheng Yuan, Feng Zhu, Qiuhong Duan

Sci Rep. 2024; 14: 10507. Published online 2024 May 7. doi: 10.1038/s41598-024-61157-5

PMCID:: PMC11076283

Abstract Article PDF–9.3M

Select item 109168662.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 106477953.

Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells

Ying Zhang, Huanyu Zheng, Ming Xu, Noriko Maeda, Ryouichi Tsunedomi, Hiroko Kishi, Hiroaki Nagano, Sei Kobayashi

Int J Mol Sci. 2023 Nov; 24(21): 15980. Published online 2023 Nov 5. doi: 10.3390/ijms242115980

PMCID:: PMC10647795

Abstract Article PDF–3.5M

Select item 101894954.

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K.T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage

iScience. 2023 May 19; 26(5): 106701. Published online 2023 Apr 18. doi: 10.1016/j.isci.2023.106701

PMCID:: PMC10189495

Abstract Article PDF–5.3M

Select item 100729065.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 99786356.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 99011607.

FYN: emerging biological roles and potential therapeutic targets in cancer

SanFei Peng, Yang Fu

J Transl Med. 2023; 21: 84. Published online 2023 Feb 5. doi: 10.1186/s12967-023-03930-0

PMCID:: PMC9901160

Abstract Article PDF–1.5M

Select item 97979888.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 91754829.

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression

Xuexue Xu, Pengsheng Ding, Lan Shi, Gang Wu, Xiaoling Ma

BMC Cancer. 2022; 22: 630. Published online 2022 Jun 8. doi: 10.1186/s12885-022-09680-4

PMCID:: PMC9175482

Abstract Article PDF–15M

Select item 899431910.

A new finding in the key prognosis-related proto-oncogene FYN in hepatocellular carcinoma based on the WGCNA hub-gene screening trategy

Chenkai Huang, Juanjuan Zhou, Yuan Nie, Guihai Guo, Anjiang Wang, Xuan Zhu

BMC Cancer. 2022; 22: 380. Published online 2022 Apr 9. doi: 10.1186/s12885-022-09388-5

PMCID:: PMC8994319

Abstract Article PDF–4.4M

Select item 889938911.

Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling

Rebecca Cabral-Dias, Stefanie Lucarelli, Karolina Zak, Sadia Rahmani, Gurjeet Judge, John Abousawan, Laura F. DiGiovanni, Dafne Vural, Karen E. Anderson, Michael G. Sugiyama, Gizem Genc, Wanjin Hong, Roberto J. Botelho, Gregory D. Fairn, Peter K. Kim, Costin N. Antonescu

J Cell Biol. 2022 Apr 4; 221(4): e201808181. Published online 2022 Mar 3. doi: 10.1083/jcb.201808181

PMCID:: PMC8899389

Abstract Article PDF–7.1M

Select item 856647312.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 855290713.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 835481814.

Profibrotic epithelial TGF-β1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN

Carmen Veith, Milena Hristova, Karamatullah Danyal, Aida Habibovic, Christopher M. Dustin, John E. McDonough, Bart M. Vanaudenaerde, Michael Kreuter, Marc A. Schneider, Nicolas Kahn, Frederik J. van Schooten, Agnes W. Boots, Albert van der Vliet

Am J Physiol Lung Cell Mol Physiol. 2021 Mar 1; 320(3): L356–L367. Published online 2020 Dec 16. doi: 10.1152/ajplung.00444.2019

PMCID:: PMC8354818

Abstract Article

Select item 821170015.

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Nicole Mentens, Olga Gielen, Kris Jacobs, Michael Broux, Gregor Verhoef, Lucienne Michaux, Carlos Graux, Iwona Wlodarska, Philippe Gaulard, Laurence de Leval, Thomas Tousseyn, Jan Cools, Daan Dierickx

Nat Commun. 2021; 12: 3705. Published online 2021 Jun 17. doi: 10.1038/s41467-021-24037-4

PMCID:: PMC8211700

Abstract Article PDF–5.6M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 807916617.

Synergy and allostery in ligand binding by HIV-1 Nef

Abdullah Aldehaiman, Afaque A. Momin, Audrey Restouin, Luyao Wang, Xiaoli Shi, Safia Aljedani, Sandrine Opi, Adrien Lugari, Umar F. Shahul Hameed, Luc Ponchon, Xavier Morelli, Mingdong Huang, Christian Dumas, Yves Collette, Stefan T. Arold

Biochem J. 2021 Apr 30; 478(8): 1525–1545. Prepublished online 2021 Mar 31. Published online 2021 Apr 21. doi: 10.1042/BCJ20201002

Correction in:: Biochem J. 2021 Oct 29; 478(20): 3807.

PMCID:: PMC8079166

Abstract Article PDF–9.8M

Select item 801500018.

FYN and ABL Regulate the Interaction Networks of the DCBLD Receptor Family

Anna M. Schmoker, Jaye L. Weinert, Jacob M. Markwood, Kathryn S. Albretsen, Michelle L. Lunde, Marion E. Weir, Alicia M. Ebert, Karen L. Hinkle, Bryan A. Ballif

Mol Cell Proteomics. 2020 Oct; 19(10): 1586–1601. Published online 2020 Nov 25. doi: 10.1074/mcp.RA120.002163

PMCID:: PMC8015000

Abstract Article PDF–2.9M

Select item 794894719.

Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation

Goce Taleski, Diana Schuhmacher, Henry Su, Jean-Marie Sontag, Estelle Sontag

J Biol Chem. 2021 Jan-Jun; 296: 100237. Published online 2021 Jan 7. doi: 10.1074/jbc.RA120.016069

PMCID:: PMC7948947

Abstract Article PDF–3.5M

Select item 787755320.

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

Travis Rush, Jonathan R. Roth, Samantha J. Thompson, Adam R. Aldaher, J. Nicholas Cochran, Erik D. Roberson

Neurobiol Dis. Author manuscript; available in PMC 2021 Feb 11.

Published in final edited form as: Neurobiol Dis. 2020 Feb; 134: 104668. Published online 2019 Nov 5. doi: 10.1016/j.nbd.2019.104668

PMCID:: PMC7877553

Abstract Article PDF–2.3M

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