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Items: 1 to 20 of 26

1.
Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10
Pratik Rajendra Patil, A. Maxwell Burroughs, Mohit Misra, Federico Cerullo, Carlos Costas-Insua, Hao-Chih Hung, Ivan Dikic, L. Aravind, Claudio A.P. Joazeiro
Cell Rep. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113100. Published online 2023 Sep 6. doi: 10.1016/j.celrep.2023.113100
PMCID:
PMC10591846
AbstractArticlePDF–1.9M
2.
Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets
Filip Mihalič, Caroline Benz, Eszter Kassa, Richard Lindqvist, Leandro Simonetti, Raviteja Inturi, Hanna Aronsson, Eva Andersson, Celestine N. Chi, Norman E. Davey, Anna K. Överby, Per Jemth, Ylva Ivarsson
Nat Commun. 2023; 14: 5636. Published online 2023 Sep 13. doi: 10.1038/s41467-023-41312-8
PMCID:
PMC10499821
AbstractArticlePDF–2.6M
3.
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer
Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang, Jing Gao
Cell Commun Signal. 2022; 20: 170. Published online 2022 Oct 28. doi: 10.1186/s12964-022-00984-3
PMCID:
PMC9615392
AbstractArticlePDF–13M
4.
EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing
Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6
PMCID:
PMC8748958
AbstractArticlePDF–3.0M
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing
Anna Thrun, Aitor Garzia, Yu Kigoshi-Tansho, Pratik R. Patil, Charles S. Umbaugh, Teresa Dallinger, Jia Liu, Sylvia Kreger, Annarita Patrizi, Gregory A. Cox, Thomas Tuschl, Claudio A.P. Joazeiro
Mol Cell. Author manuscript; available in PMC 2022 May 20.
Published in final edited form as: Mol Cell. 2021 May 20; 81(10): 2112–2122.e7. Published online 2021 Apr 27. doi: 10.1016/j.molcel.2021.03.004
PMCID:
PMC8141035
AbstractArticlePDF–1.3M
7.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
8.
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease
Ruinan Shen, Xiaobei Zhao, Lu He, Yongbo Ding, Wei Xu, Suzhen Lin, Savannah Fang, Wanlin Yang, Kijung Sung, Brian Spencer, Robert A. Rissman, Ming Lei, Jianqing Ding, Chengbiao Wu
Transl Neurodegener. 2020; 9: 26. Published online 2020 Jun 18. doi: 10.1186/s40035-020-00206-1
PMCID:
PMC7301499
AbstractArticlePDF–14M
9.
ARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection
Ruth Hüttenhain, Jiewei Xu, Lily A. Burton, David E. Gordon, Judd F. Hultquist, Jeffrey R. Johnson, Laura Satkamp, Joseph Hiatt, David Y. Rhee, Kheewoong Baek, David C. Crosby, Alan D. Frankel, Alexander Marson, J. Wade Harper, Arno F. Alpi, Brenda A. Schulman, John D. Gross, Nevan J. Krogan
Cell Host Microbe. Author manuscript; available in PMC 2020 Jul 10.
Published in final edited form as: Cell Host Microbe. 2019 Jul 10; 26(1): 86–99.e7. Published online 2019 Jun 25. doi: 10.1016/j.chom.2019.05.008
PMCID:
PMC7153695
AbstractArticlePDF–2.6M
10.
The Eukaryotic Proteome is Shaped by E3 Ubiquitin Ligases Targeting C-terminal Degrons
Itay Koren, Richard T. Timms, Tomasz Kula, Qikai Xu, Mamie Z. Li, Stephen J. Elledge
Cell. Author manuscript; available in PMC 2019 Jun 14.
Published in final edited form as: Cell. 2018 Jun 14; 173(7): 1622–1635.e14. Published online 2018 May 17. doi: 10.1016/j.cell.2018.04.028
PMCID:
PMC6003881
AbstractArticlePDF–933K
11.
Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions
Kinga Winczura, Manfred Schmid, Claudia Iasillo, Kelly R. Molloy, Lea Mørch Harder, Jens S. Andersen, John LaCava, Torben Heick Jensen
Cell Rep. 2018 Jan 2; 22(1): 44–58. Published online 2018 Jan 2. doi: 10.1016/j.celrep.2017.12.037
PMCID:
PMC5770337
AbstractArticle
12.
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski
BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9
PMCID:
PMC5678581
AbstractArticlePDF–3.2M
13.
Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase
Daniel C. Scott, Jared T. Hammill, Jaeki Min, David Y. Rhee, Michele Connelly, Vladislav O. Sviderskiy, Deepak Bhasin, Yizhe Chen, Su-Sien Ong, Sergio C. Chai, Asli N. Goktug, Guochang Huang, Julie K. Monda, Jonathan Low, Ho Shin Kim, Joao A. Paulo, Joe R. Cannon, Anang A. Shelat, Taosheng Chen, Ian R. Kelsall, Arno F. Alpi, Vishwajeeth Pagala, Xusheng Wang, Junmin Peng, Bhuvanesh Singh, J. Wade Harper, Brenda A. Schulman, R. Kip Guy
Nat Chem Biol. Author manuscript; available in PMC 2017 Dec 5.
Published in final edited form as: Nat Chem Biol. 2017 Aug; 13(8): 850–857. Published online 2017 Jun 5. doi: 10.1038/nchembio.2386
PMCID:
PMC5577376
AbstractArticlePDF–1.2M
14.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
15.
USP25 regulates Wnt signaling by controlling the stability of tankyrases
Daichao Xu, Jianping Liu, Tao Fu, Bing Shan, Lihui Qian, Lifeng Pan, Junying Yuan
Genes Dev. 2017 May 15; 31(10): 1024–1035. doi: 10.1101/gad.300889.117
PMCID:
PMC5495119
AbstractArticlePDF–666K
16.
Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones
Anna Malinová, Zuzana Cvačková, Daniel Matějů, Zuzana Hořejší, Claire Abéza, Franck Vandermoere, Edouard Bertrand, David Staněk, Céline Verheggen
J Cell Biol. 2017 Jun 5; 216(6): 1579–1596. doi: 10.1083/jcb.201701165
PMCID:
PMC5461031
AbstractArticlePDF–2.9M
17.
Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation
Daniel C. Scott, David Y. Rhee, David M. Duda, Ian R. Kelsall, Jennifer L. Olszewski, Joao A. Paulo, Annemieke de Jong, Huib Ovaa, Arno F. Alpi, J. Wade Harper, Brenda A. Schulman
Cell. Author manuscript; available in PMC 2017 Aug 25.
Published in final edited form as: Cell. 2016 Aug 25; 166(5): 1198–1214.e24. doi: 10.1016/j.cell.2016.07.027
PMCID:
PMC5091668
AbstractArticlePDF–4.2M
18.
?F508 CFTR interactome remodeling promotes rescue of Cystic Fibrosis
Sandra Pankow, Casimir Bamberger, Diego Calzolari, Salvador Martínez-Bartolomé, Mathieu Lavallée-Adam, William E. Balch, John R. Yates, III
Nature. Author manuscript; available in PMC 2016 May 30.
Published in final edited form as: Nature. 2015 Dec 24; 528(7583): 510–516. Published online 2015 Nov 30. doi: 10.1038/nature15729
PMCID:
PMC4826614
AbstractArticlePDF–5.7M
19.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
20.
Systematic VCP-UBXD Adaptor Network Proteomics Identifies a Role for UBXN10 in Regulating Ciliogenesis
Malavika Raman, Mikhail Sergeev, Maija Garnaas, John R. Lydeard, Edward L. Huttlin, Wolfram Goessling, Jagesh V. Shah, J. Wade Harper
Nat Cell Biol. Author manuscript; available in PMC 2016 Apr 1.
Published in final edited form as: Nat Cell Biol. 2015 Oct; 17(10): 1356–1369. Published online 2015 Sep 21. doi: 10.1038/ncb3238
Correction in:
Nat Cell Biol. 2016 Mar; 18(3): 347.
PMCID:
PMC4610257
AbstractArticlePDF–4.5M

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