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Select item 107101321.

PAM variants in patients with thyrotrophinomas, cyclical Cushing’s disease and prolactinomas

Sunita M. C. De Sousa, Angeline Shen, Christopher J. Yates, Roderick Clifton-Bligh, Stephen Santoreneos, James King, John Toubia, Giampaolo Trivellin, Andrea G. Lania, Constantine A. Stratakis, David J. Torpy, Hamish S. Scott

Front Endocrinol (Lausanne) 2023; 14: 1305606. Published online 2023 Nov 23. doi: 10.3389/fendo.2023.1305606

PMCID:: PMC10710132

Abstract Article PDF–2.4M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 92316233.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80459325.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington

Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331

PMCID:: PMC8045932

Abstract Article PDF–1.9M

Select item 78645906.

PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice

Yi-Chun Chen, Richard E. Mains, Betty A. Eipper, Brad G. Hoffman, Traci A. Czyzyk, John E. Pintar, C. Bruce Verchere

Diabetologia. Author manuscript; available in PMC 2021 Feb 5.

Published in final edited form as: Diabetologia. 2020 Mar; 63(3): 561–576. Published online 2020 Jan 27. doi: 10.1007/s00125-019-05060-z

Correction in:: Diabetologia. 2020 Mar 14

PMCID:: PMC7864590

Abstract Article PDF–2.6M

Select item 62372737.

Type 2 Diabetes Risk Alleles in PAM Impact Insulin Release from Human Pancreatic Beta Cells

Soren K. Thomsen, Anne Raimondo, Benoit Hastoy, Shahana Sengupta, Xiao-Qing Dai, Austin Bautista, Jenny Censin, Anthony J. Payne, Mahesh M. Umapathysivam, Aliya F Spigelman, Amy Barrett, Christopher J. Groves, Nicola L. Beer, Jocelyn E. Manning Fox, Mark I. McCarthy, Anne Clark, Anubha Mahajan, Patrik Rorsman, Patrick E. MacDonald, Anna L. Gloyn

Nat Genet. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Nat Genet. 2018 Aug; 50(8): 1122–1131. Published online 2018 Jul 27. doi: 10.1038/s41588-018-0173-1

PMCID:: PMC6237273

Abstract Article PDF–2.4M

Select item 61309508.

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

Muriel Desbois, Oliver Crawley, Paul R. Evans, Scott T. Baker, Ikuo Masuho, Ryohei Yasuda, Brock Grill

J Biol Chem. 2018 Sep 7; 293(36): 13897–13909. Published online 2018 Jul 11. doi: 10.1074/jbc.RA118.002176

PMCID:: PMC6130950

Abstract Article PDF–2.5M

Select item 60777229.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 574982510.

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation

Anna Stockum, Ambrosius P. Snijders, Goedele N. Maertens

PLoS One. 2018; 13(1): e0190513. Published online 2018 Jan 2. doi: 10.1371/journal.pone.0190513

PMCID:: PMC5749825

Abstract Article PDF–8.0M

Select item 569673211.

The peptidylglycine-α-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population

Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Jey Sook Chae, Sang-Hyun Lee, Jong Ho Lee

Hum Genomics. 2017; 11: 29. Published online 2017 Nov 21. doi: 10.1186/s40246-017-0125-3

PMCID:: PMC5696732

Abstract Article PDF–410K

Select item 559213512.

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together

Nils Bäck, Kristiina Kanerva, Vishwanatha Kurutihalli, Andrew Yanik, Elina Ikonen, Richard E. Mains, Betty A. Eipper

Eur J Cell Biol. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Eur J Cell Biol. 2017 Aug; 96(5): 407–417. Published online 2017 Mar 28. doi: 10.1016/j.ejcb.2017.03.007

PMCID:: PMC5592135

Abstract Article PDF–2.0M

Select item 555356813.

A role for mitochondrial translation in promotion of viability in K-Ras mutant cells

Timothy D. Martin, Danielle R. Cook, Mei Yuk Choi, Mamie Z. Li, Kevin M. Haigis, Stephen J. Elledge

Cell Rep. Author manuscript; available in PMC 2017 Aug 11.

Published in final edited form as: Cell Rep. 2017 Jul 11; 20(2): 427–438. doi: 10.1016/j.celrep.2017.06.061

PMCID:: PMC5553568

Abstract Article PDF–1.8M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 487961815.

Stopped-Flow Studies of the Reduction of the Copper Centers Suggest a Bifurcated Electron Transfer Pathway in Peptidylglycine Monooxygenase

Shefali Chauhan, Parisa Hosseinzadeh, Yi Lu, Ninian J. Blackburn

Biochemistry. Author manuscript; available in PMC 2017 Apr 5.

Published in final edited form as: Biochemistry. 2016 Apr 5; 55(13): 2008–2021. Published online 2016 Mar 23. doi: 10.1021/acs.biochem.6b00061

PMCID:: PMC4879618

Abstract Article PDF–1.4M

Select item 475775916.

Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

Yuta Hatori, Ye Yan, Katharina Schmidt, Eri Furukawa, Nesrin M. Hasan, Nan Yang, Chin-Nung Liu, Shanthini Sockanathan, Svetlana Lutsenko

Nat Commun. 2016; 7: 10640. Published online 2016 Feb 16. doi: 10.1038/ncomms10640

PMCID:: PMC4757759

Abstract Article PDF–1.6M

Select item 461721117.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 459900918.

A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells

Feihan F. Dai, Alpana Bhattacharjee, Ying Liu, Battsetseg Batchuluun, Ming Zhang, Xinye Serena Wang, Xinyi Huang, Lemieux Luu, Dan Zhu, Herbert Gaisano, Michael B. Wheeler

J Biol Chem. 2015 Oct 9; 290(41): 25045–25061. Published online 2015 Aug 13. doi: 10.1074/jbc.M115.648592

PMCID:: PMC4599009

Abstract Article PDF–2.7M

Select item 459899819.

Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells

Peter D. Simpson, Betty A. Eipper, Maximiliano J. Katz, Lautaro Gandara, Pablo Wappner, Roman Fischer, Emma J. Hodson, Peter J. Ratcliffe, Norma Masson

J Biol Chem. 2015 Oct 9; 290(41): 24891–24901. Published online 2015 Aug 19. doi: 10.1074/jbc.M115.667246

PMCID:: PMC4598998

Abstract Article PDF–2.7M

Select item 377350520.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

Simona Principe, E. Ellen Jones, Yunee Kim, Ankit Sinha, Julius O. Nyalwidhe, Jasmin Brooks, O. John Semmes, Dean A. Troyer, Raymond S. Lance, Thomas Kislinger, Richard R. Drake

Proteomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Proteomics. 2013 May; 13(0): 1667–1671. Published online 2013 Apr 23. doi: 10.1002/pmic.201200561

PMCID:: PMC3773505

Abstract Article PDF–630K

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