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Select item 106832401.

Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer

Zheqiong Tan, Pragney Deme, Keerti Boyapati, Britt S. R. Claes, Annet A. M. Duivenvoorden, Ron M. A. Heeren, Caitlin M. Tressler, Norman James Haughey, Kristine Glunde

Breast Cancer Res. 2023; 25: 148. Published online 2023 Nov 28. doi: 10.1186/s13058-023-01742-0

PMCID:: PMC10683240

Abstract Article PDF–15M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99786353.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71705225.

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA₂γ knockout

Xinping Liu, Harold F. Sims, Christopher M. Jenkins, Shaoping Guan, Beverly G. Dilthey, Richard W. Gross

J Biol Chem. 2020 Apr 17; 295(16): 5307–5320. Published online 2020 Mar 11. doi: 10.1074/jbc.RA119.012296

PMCID:: PMC7170522

Abstract Article PDF–3.1M

Select item 67781376.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 65811977.

Gain of additional BIRC3 protein functions through 3′UTR-mediated protein complex formation

Shih-Han Lee, Christine Mayr

Mol Cell. Author manuscript; available in PMC 2020 May 16.

Published in final edited form as: Mol Cell. 2019 May 16; 74(4): 701–712.e9. Published online 2019 Apr 1. doi: 10.1016/j.molcel.2019.03.006

PMCID:: PMC6581197

Abstract Article PDF–2.0M

Select item 61666828.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 59184169.

A Neurodegenerative Mitochondrial Disease Phenotype Due to Biallelic Loss-of-function Variants in PNPLA8 Encoding Calcium-independent Phospholipase A2γ

Anju Shukla, Russell P Saneto, Malavika Hebbar, Ghayda Mirzaa, Katta M Girisha

Am J Med Genet A. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Am J Med Genet A. 2018 May; 176(5): 1232–1237. doi: 10.1002/ajmg.a.38687

PMCID:: PMC5918416

Abstract Article PDF–659K

Select item 586483210.

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

Xiaonan Liu, Kari Salokas, Fitsum Tamene, Yaming Jiu, Rigbe G. Weldatsadik, Tiina Öhman, Markku Varjosalo

Nat Commun. 2018; 9: 1188. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03523-2

PMCID:: PMC5864832

Abstract Article PDF–4.5M

Select item 583915811.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 576691312.

Heart failure–induced activation of phospholipase iPLA₂γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore

Sung Ho Moon, Xinping Liu, Ari M. Cedars, Kui Yang, Michael A. Kiebish, Susan M. Joseph, John Kelley, Christopher M. Jenkins, Richard W. Gross

J Biol Chem. 2018 Jan 5; 293(1): 115–129. Published online 2017 Nov 20. doi: 10.1074/jbc.RA117.000405

PMCID:: PMC5766913

Abstract Article PDF–1.1M

Select item 548157213.

The phospholipase iPLA₂γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling

Gao-Yuan Liu, Sung Ho Moon, Christopher M. Jenkins, Maoyin Li, Harold F. Sims, Shaoping Guan, Richard W. Gross

J Biol Chem. 2017 Jun 23; 292(25): 10672–10684. Published online 2017 Apr 25. doi: 10.1074/jbc.M117.783068

PMCID:: PMC5481572

Abstract Article PDF–2.7M

Select item 436130714.

Loss of function variants in human PNPLA8 encoding calcium-independent phospholipase A₂γ recapitulate the mitochondriopathy of the homologous null mouse

Carol J. Saunders, Sung Ho Moon, Xinping Liu, Isabelle Thiffault, Keith Coffman, Jean-Baptiste LePichon, Eugenio Taboada, Laurie D. Smith, Emily G. Farrow, Neil Miller, Margaret Gibson, Melanie Patterson, Stephen F. Kingsmore, Richard W. Gross

Hum Mutat. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: Hum Mutat. 2015 Mar; 36(3): 301–306. doi: 10.1002/humu.22743

Correction in:: volume 36 on page 656

PMCID:: PMC4361307

Abstract Article PDF–506K

Select item 427556915.

Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence

Dankyu Yoon, Young-Jin Kim, Wen-Yan Cui, Andrew Van der Vaart, Yoon Shin Cho, Jong-Young Lee, Jennie Z. Ma, Thomas J. Payne, Ming D. Li, Taesung Park

Hum Genet. Author manuscript; available in PMC 2014 Dec 24.

Published in final edited form as: Hum Genet. 2012 Jun; 131(6): 1009–1021. Published online 2011 Oct 18. doi: 10.1007/s00439-011-1102-x

PMCID:: PMC4275569

Abstract Article PDF–1.1M

Select item 419690216.

Group VIB Calcium-Independent Phospholipase A₂ (iPLA₂γ) Regulates Platelet Activation, Hemostasis and Thrombosis in Mice

Emiko Yoda, Kohmi Rai, Mai Ogawa, Yuki Takakura, Hiroshi Kuwata, Hidenori Suzuki, Yoshihito Nakatani, Makoto Murakami, Shuntaro Hara

PLoS One. 2014; 9(10): e109409. Published online 2014 Oct 14. doi: 10.1371/journal.pone.0109409

PMCID:: PMC4196902

Abstract Article PDF–1.2M

Select item 369761117.

The Absence of Myocardial Calcium-Independent Phospholipase A₂γ Results in Impaired Prostaglandin E₂ Production and Decreased Survival in Mice with Acute Trypanosoma cruzi Infection

Janhavi Sharma, Christopher S. Eickhoff, Daniel F. Hoft, David A. Ford, Richard W. Gross, Jane McHowat

Infect Immun. 2013 Jul; 81(7): 2278–2287. doi: 10.1128/IAI.00497-12

PMCID:: PMC3697611

Abstract Article PDF–1.0M

Select item 360398918.

Fine Mapping for Weaver Syndrome in Brown Swiss Cattle and the Identification of 41 Concordant Mutations across NRCAM, PNPLA8 and CTTNBP2

Matthew McClure, Euisoo Kim, Derek Bickhart, Daniel Null, Tabatha Cooper, John Cole, George Wiggans, Paolo Ajmone-Marsan, Licia Colli, Enrico Santus, George E. Liu, Steve Schroeder, Lakshmi Matukumalli, Curt Van Tassell, Tad Sonstegard

PLoS One. 2013; 8(3): e59251. Published online 2013 Mar 20. doi: 10.1371/journal.pone.0059251

PMCID:: PMC3603989

Abstract Article PDF–923K

Select item 356764119.

Complement-mediated Activation of Calcium-independent Phospholipase A₂γ: ROLE OF PROTEIN KINASES AND PHOSPHORYLATION

Hanan Elimam, Joan Papillon, Tomoko Takano, Andrey V. Cybulsky

J Biol Chem. 2013 Feb 8; 288(6): 3871–3885. Published online 2012 Dec 20. doi: 10.1074/jbc.M112.396614

PMCID:: PMC3567641

Abstract Article PDF–2.3M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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