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Select item 107649581.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516153.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 97725584.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 97696985.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 97080866.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 95699557.

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation

Yulemi Gonzalez Quesada, Luc DesGroseillers

Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588

PMCID:: PMC9569955

Abstract Article PDF–2.1M

Select item 95334868.

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Yongzhen Mo, Yumin Wang, Yian Wang, Xiangying Deng, Qijia Yan, Chunmei Fan, Shuai Zhang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Qianjin Liao, Can Guo, Yong Li, Guiyuan Li, Zhaoyang Zeng, Weihong Jiang, Wei Xiong, Bo Xiang

Mol Cancer. 2022; 21: 192. Published online 2022 Oct 5. doi: 10.1186/s12943-022-01659-w

PMCID:: PMC9533486

Abstract Article PDF–12M

Select item 94819339.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 934345510.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 933831311.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 929024112.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Abstract Article PDF–8.2M

Select item 917548213.

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression

Xuexue Xu, Pengsheng Ding, Lan Shi, Gang Wu, Xiaoling Ma

BMC Cancer. 2022; 22: 630. Published online 2022 Jun 8. doi: 10.1186/s12885-022-09680-4

PMCID:: PMC9175482

Abstract Article PDF–15M

Select item 911973614.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 905883615.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 905602616.

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis

Fenglong Jiao, Clinton Yu, Andrew Wheat, Xiaorong Wang, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2022 Apr 30.

Published in final edited form as: Anal Chem. 2022 Mar 15; 94(10): 4236–4242. Published online 2022 Mar 2. doi: 10.1021/acs.analchem.1c04485

PMCID:: PMC9056026

Abstract Article PDF–1.0M

Select item 889702217.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 876007718.

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Calvo Pardo, Lu Yu, Tanaji T. Talele, Jiri Bartek, Jyoti S. Choudhary, Yves Pommier, Stephen J. Pettitt, Andrew N. J. Tutt, Kristijan Ramadan, Christopher J. Lord

Nat Cell Biol. 2022; 24(1): 62–73. Published online 2022 Jan 10. doi: 10.1038/s41556-021-00807-6