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Select item 112510551.

FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer

Nicla Lorito, Angela Subbiani, Alfredo Smiriglia, Marina Bacci, Francesca Bonechi, Laura Tronci, Elisabetta Romano, Alessia Corrado, Dario Livio Longo, Marta Iozzo, Luigi Ippolito, Giuseppina Comito, Elisa Giannoni, Icro Meattini, Alexandra Avgustinova, Paola Chiarugi, Angela Bachi, Andrea Morandi

EMBO Mol Med. 2024 Jul; 16(7): 1533–1559. Published online 2024 Jun 26. doi: 10.1038/s44321-024-00090-6

PMCID:: PMC11251055

Abstract Article PDF–9.2M

Select item 108446342.

Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function

Xueyan Wu, Lei Jiang, Hongyan Qi, Chunyan Hu, Xiaojing Jia, Hong Lin, Shuangyuan Wang, Lin Lin, Yifang Zhang, Ruizhi Zheng, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Yuhong Chen, Jie Zheng, Yufang Bi, Jieli Lu

Transl Psychiatry. 2024; 14: 77. Published online 2024 Feb 5. doi: 10.1038/s41398-024-02784-4

PMCID:: PMC10844634

Abstract Article PDF–1.3M

Select item 107991083.

Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men

Michael Fridén, Erika Olsson, Lars Lind, Fredrik Rosqvist, Ulf Risérus

Eur J Nutr. 2024; 63(1): 145–153. Published online 2023 Sep 20. doi: 10.1007/s00394-023-03249-y

PMCID:: PMC10799108

Abstract Article PDF–553K

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102293835.

Effect of FADS1 rs174556 Genotype on Polyunsaturated Fatty Acid Status: A Systematic Review and Meta-Analysis

Wen-Chieh Wu, Pei-Yu Wu, Chien-Yi Chan, Ming-Fen Lee, Chun-Yin Huang

Adv Nutr. 2023 Mar; 14(2): 352–362. Published online 2023 Feb 5. doi: 10.1016/j.advnut.2023.01.007

PMCID:: PMC10229383

Abstract Article PDF–1.7M

Select item 100901356.

FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer

Chunjie Xu, Lei Gu, Lipeng Hu, Chunhui Jiang, Qing Li, Longci Sun, Hong Zhou, Ye Liu, Hanbing Xue, Jun Li, Zhigang Zhang, Xueli Zhang, Qing Xu

Nat Commun. 2023; 14: 2042. Published online 2023 Apr 11. doi: 10.1038/s41467-023-37590-x

PMCID:: PMC10090135

Abstract Article PDF–4.6M

Select item 99191707.

Association of Fatty Acid Desaturase 1 rs174547 Polymorphism with the Composition of Long-Chain Polyunsaturated Fatty Acids in Serum Glycerophospholipids during Pregnancy

Terue Kawabata, Hideoki Fukuoka, Michiru Harada, Kumiko Shoji, Yoshinori Kubo, Chisato Mori, Kenichi Sakurai, Takeshi Ohkubo, Kyoichi Oshida, Yuichiro Yamashiro

Nutrients. 2023 Feb; 15(3): 722. Published online 2023 Jan 31. doi: 10.3390/nu15030722

PMCID:: PMC9919170

Abstract Article PDF–457K

Select item 91437608.

Investigation of Maternal Diet and FADS1 Polymorphism Associated with Long-Chain Polyunsaturated Fatty Acid Compositions in Human Milk

Sakurako Niwa, Terue Kawabata, Kumiko Shoji, Hiromitsu Ogata, Yasuo Kagawa, Kazuhiro Nakayama, Yoshiko Yanagisawa, Sadahiko Iwamoto, Nozomi Tatsuta, Kaname Asato, Takahiro Arima, Nobuo Yaegashi, Kunihiko Nakai

Nutrients. 2022 May; 14(10): 2160. Published online 2022 May 23. doi: 10.3390/nu14102160

PMCID:: PMC9143760

Abstract Article PDF–294K

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 901471110.

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

Fabian Hosp, Hannes Vossfeldt, Matthias Heinig, Djordje Vasiljevic, Anup Arumughan, Emanuel Wyler, Genetic and Environmental Risk for Alzheimer’s Disease (GERAD1) Consortium, Markus Landthaler, Norbert Hubner, Erich E. Wanker, Lars Lannfelt, Martin Ingelsson, Maciej Lalowski, Aaron Voigt, Matthias Selbach

Cell Rep. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Cell Rep. 2015 May 19; 11(7): 1134–1146. Published online 2015 May 7. doi: 10.1016/j.celrep.2015.04.030

PMCID:: PMC9014711

Abstract Article PDF–2.2M

Select item 891238211.

FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study

Jerusa da Mota Santana, Marcos Pereira, Gisele Queiroz Carvalho, Maria do Carmo Gouveia Peluzio, Iúri Drumond Louro, Djanilson Barbosa dos Santos, Ana Marlucia Oliveira

Nutrients. 2022 Mar; 14(5): 1056. Published online 2022 Mar 2. doi: 10.3390/nu14051056

PMCID:: PMC8912382

Abstract Article PDF–956K

Select item 889702212.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 886447213.

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network

Rebecca Elizabeth Kattan, Han Han, Gayoung Seo, Bing Yang, Yongqi Lin, Max Dotson, Stephanie Pham, Yahya Menely, Wenqi Wang

Mol Cell Proteomics. 2022 Feb; 21(2): 100195. Published online 2022 Jan 8. doi: 10.1016/j.mcpro.2022.100195

PMCID:: PMC8864472

Abstract Article PDF–3.6M

Select item 876007714.

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Calvo Pardo, Lu Yu, Tanaji T. Talele, Jiri Bartek, Jyoti S. Choudhary, Yves Pommier, Stephen J. Pettitt, Andrew N. J. Tutt, Kristijan Ramadan, Christopher J. Lord

Nat Cell Biol. 2022; 24(1): 62–73. Published online 2022 Jan 10. doi: 10.1038/s41556-021-00807-6

PMCID:: PMC8760077

Abstract Article PDF–12M

Select item 859029215.

CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia–reperfusion injury in vivo and in vitro

Yun Ding, Pengjie Tu, Yiyong Chen, Yangyun Huang, Xiaojie Pan, Wenshu Chen

Respir Res. 2021; 22: 291. Published online 2021 Nov 13. doi: 10.1186/s12931-021-01891-w

PMCID:: PMC8590292

Abstract Article PDF–3.3M

Select item 835182316.

Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus

Shilpa S Shetty, Kumari N Suchetha, Devi Harshini, KP Sharmila, Srinidhi Rai

Afr Health Sci. 2020 Dec; 20(4): 1770–1776. doi: 10.4314/ahs.v20i4.30

PMCID:: PMC8351823

Abstract Article PDF–445K

Select item 821738717.

Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality

Tiffany Thomas, Francesca Cendali, Xiaoyun Fu, Fabia Gamboni, Evan J. Morrison, Jonathan Beirne, Travis Nemkov, Marianna H. Antonelou, Anastasios Kriebardis, Ian Welsby, Ariel Hay, Karolina H. Dziewulska, Michael P. Busch, Steven Kleinman, Paul W Buehler, Steven L Spitalnik, James C. Zimring, Angelo D’Alessandro

Transfusion. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Transfusion. 2021 Jun; 61(6): 1867–1883. Published online 2021 Apr 26. doi: 10.1111/trf.16402

PMCID:: PMC8217387

Abstract Article PDF–3.5M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 789446019.

Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity

Chenxuan Wang, Jessica Murphy, Kerri Z. Delaney, Natalie Khor, José A. Morais, Michael A. Tsoukas, Dana E. Lowry, David M. Mutch, Sylvia Santosa

Adipocyte. 2021; 10(1): 124–130. Published online 2021 Feb 17. doi: 10.1080/21623945.2021.1888470

PMCID:: PMC7894460

Abstract Article PDF–427K

Select item 752298520.

FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids

Lindsay M. Reynolds, Rahul Dutta, Michael C. Seeds, Kirsten N. Lake, Brian Hallmark, Rasika A. Mathias, Timothy D. Howard, Floyd H. Chilton

Sci Rep. 2020; 10: 15873. Published online 2020 Sep 28. doi: 10.1038/s41598-020-71948-1

PMCID:: PMC7522985

Abstract Article PDF–4.0M

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