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Select item 110742991.

Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis

Chao-Yu Yang, Chia-I Lien, Yi-Chun Tseng, Yi-Fan Tu, Arkadiusz W. Kulczyk, Yen-Chen Lu, Yin-Ting Wang, Tsung-Wei Su, Li-Chung Hsu, Yu-Chih Lo, Su-Chang Lin

Nat Commun. 2024; 15: 3791. Published online 2024 May 6. doi: 10.1038/s41467-024-47990-2

PMCID:: PMC11074299

Abstract Article PDF–5.7M

Select item 102485542.

The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity

Sahezeel Awadia, Merna Sitto, Sundaresh Ram, Wenbin Ji, Yajing Liu, Raheema Damani, Dipankar Ray, Theodore S. Lawrence, Craig J. Galban, Steven D. Cappell, Alnawaz Rehemtulla

J Biol Chem. 2023 Jun; 299(6): 104786. Published online 2023 May 4. doi: 10.1016/j.jbc.2023.104786

PMCID:: PMC10248554

Abstract Article PDF–6.8M

Select item 102443833.

IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death

Choong-Sil Lee, Gyuho Hwang, Young Woo Nam, Chi Hyun Hwang, Jaewhan Song

Cell Death Differ. 2023 Jun; 30(6): 1575–1584. Published online 2023 Apr 21. doi: 10.1038/s41418-023-01161-w

PMCID:: PMC10244383

Abstract Article PDF–2.8M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99284565.

FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition

Yan Lin, Fangfang Cai, Xiaoyang Wang, Yunwen Yang, Yongzhe Ren, Chun Yao, Xiaoxing Yin, Hongqin Zhuang, Zichun Hua

Cell Cycle. 2023; 22(5): 580–595. Published online 2022 Oct 24. doi: 10.1080/15384101.2022.2136463

PMCID:: PMC9928456

Abstract Article PDF–3.7M

Select item 97385226.

A Dual Role for FADD in Human Precursor T-Cell Neoplasms

José Luis Marín-Rubio, Laura Vela-Martín, Jack Gudgeon, Eduardo Pérez-Gómez, Frances R. Sidgwick, Matthias Trost, Debbie L. Cunningham, Javier Santos, José Fernández-Piqueras, María Villa-Morales

Int J Mol Sci. 2022 Dec; 23(23): 15157. Published online 2022 Dec 2. doi: 10.3390/ijms232315157

PMCID:: PMC9738522

Abstract Article PDF–2.5M

Select item 93600007.

OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Daisuke Oikawa, Min Gi, Hidetaka Kosako, Kouhei Shimizu, Hirotaka Takahashi, Masayuki Shiota, Shuhei Hosomi, Keidai Komakura, Hideki Wanibuchi, Daisuke Tsuruta, Tatsuya Sawasaki, Fuminori Tokunaga

Cell Death Dis. 2022 Aug; 13(8): 694. Published online 2022 Aug 8. doi: 10.1038/s41419-022-05145-5

PMCID:: PMC9360000

Abstract Article PDF–6.1M

Select item 92792858.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91776949.

Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1

Yiming Hu, Haohao Zhang, Ningxia Xie, Dandan Liu, Yuhang Jiang, Zhi Liu, Deji Ye, Sanhong Liu, Xi Chen, Cuifeng Li, Qi Wang, Xingxu Huang, Yongzhong Liu, Yufang Shi, Xiaoren Zhang

Cell Death Differ. 2022 Jun; 29(6): 1176–1186. Published online 2021 Dec 1. doi: 10.1038/s41418-021-00908-7

PMCID:: PMC9177694

Abstract Article PDF–3.7M

Select item 917759910.

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB

Minho Won, Kyeong Ah Park, Sup Kim, Eunjin Ju, Youngbok Ko, Heonjong Yoo, Hyunju Ro, Jaeseob Lee, Junseo Oh, Eun Gyo Lee, Sang Yean Kim, Suk Woo Nam, Han-Ming Shen, Min-Kyung Yeo, Jin Man Kim, Gang Min Hur

Cell Death Differ. 2022 Jun; 29(6): 1152–1163. Published online 2021 Nov 27. doi: 10.1038/s41418-021-00906-9

PMCID:: PMC9177599

Abstract Article PDF–3.4M

Select item 913490911.

The Classical Apoptotic Adaptor FADD Regulates Glycolytic Capacity in Acute Lymphoblastic Leukemia

Wenzhao Zhou, Yueyang Lai, Jianhui Zhu, Xuebo Xu, Wenliang Yu, Zengzheng Du, Leyang Wu, Xuerui Zhang, Zichun Hua

Int J Biol Sci. 2022; 18(8): 3137–3155. Published online 2022 May 1. doi: 10.7150/ijbs.68016

PMCID:: PMC9134909

Abstract Article PDF–3.6M

Select item 904055612.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 886377313.

The deubiquitinase Usp27x as a novel regulator of cFLIP_L protein expression and sensitizer to death-receptor-induced apoptosis

Manuel Nico Dold, Xiulin Ng, Claudia Alber, Ian Edward Gentle, Georg Häcker, Arnim Weber

Apoptosis. 2022; 27(1-2): 112–132. Published online 2022 Jan 19. doi: 10.1007/s10495-021-01706-9

PMCID:: PMC8863773

Abstract Article PDF–2.7M

Select item 837349114.

Development and Validation of an Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma

Chang Liu, Wenling Wu, Meng Xu, Jinglin Mi, Longjiang Xu, Rensheng Wang

Biomed Res Int. 2021; 2021: 1028158. Published online 2021 Aug 11. doi: 10.1155/2021/1028158

PMCID:: PMC8373491

Abstract Article PDF–3.1M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 796219416.

Loss of FADD and Caspases Affects the Response of T-Cell Leukemia Jurkat Cells to Anti-Cancer Drugs

Zuzana Mrkvová, Michaela Portešová, Iva Slaninová

Int J Mol Sci. 2021 Mar; 22(5): 2702. Published online 2021 Mar 7. doi: 10.3390/ijms22052702

PMCID:: PMC7962194

Abstract Article PDF–3.0M

Select item 786495917.

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane

Nat Commun. 2021; 12: 819. Published online 2021 Feb 5. doi: 10.1038/s41467-020-20806-9

PMCID:: PMC7864959

Abstract Article PDF–8.3M

Select item 781571918.

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP_L

Osamu Nakabayashi, Hirotaka Takahashi, Kenta Moriwaki, Sachiko Komazawa-Sakon, Fumiaki Ohtake, Shin Murai, Yuichi Tsuchiya, Yuki Koyahara, Yasushi Saeki, Yukiko Yoshida, Soh Yamazaki, Fuminori Tokunaga, Tatsuya Sawasaki, Hiroyasu Nakano

Commun Biol. 2021; 4: 80. Published online 2021 Jan 19. doi: 10.1038/s42003-020-01603-y

PMCID:: PMC7815719

Abstract Article PDF–4.3M

Select item 753254119.

AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway

Tianke Chen, Xiaowei Dai, Juji Dai, Chaodong Ding, Zheng Zhang, Ziqi Lin, Jin Hu, Mei Lu, Zhanyu Wang, Yalei Qi, Li Zhang, Rulu Pan, Zhu Zhao, Liting Lu, Wanqin Liao, Xincheng Lu

Cell Death Dis. 2020 Oct; 11(10): 822. Published online 2020 Oct 2. doi: 10.1038/s41419-020-03030-7

PMCID:: PMC7532541

Abstract Article PDF–2.7M

Select item 742984520.

The SCF^Skp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

Jamie Z. Roberts, Caitriona Holohan, Tamas Sessler, Jennifer Fox, Nyree Crawford, Joel S. Riley, Hajrah Khawaja, Joanna Majkut, Emma Evergren, Luke M. Humphreys, Jennifer Ferris, Catherine Higgins, Margarita Espona-Fiedler, Paul Moynagh, Simon S. McDade, Daniel B. Longley

Cell Death Differ. 2020 Sep; 27(9): 2726–2741. Published online 2020 Apr 20. doi: 10.1038/s41418-020-0539-7

PMCID:: PMC7429845

Abstract Article PDF–4.6M

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