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Select item 111137321.

Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer

Marcello Pinti, Lara Gibellini, Yongzhang Liu, Shan Xu, Bin Lu, Andrea Cossarizza

Cell Mol Life Sci. 2015 Dec; 72(24): 4807–4824. Published online 2015 Sep 12. doi: 10.1007/s00018-015-2039-3

PMCID:: PMC11113732

Abstract Article PDF–988K

Select item 109332672.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 108508183.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 107403904.

Intraneuronal β-amyloid impaired mitochondrial proteostasis through the impact on LONP1

Wenzhang Wang, Xiaopin Ma, Sabina Bhatta, Changjuan Shao, Fanpeng Zhao, Hisashi Fujioka, Sandy Torres, Fengqin Wu, Xiongwei Zhu

Proc Natl Acad Sci U S A. 2023 Dec 19; 120(51): e2316823120. Published online 2023 Dec 13. doi: 10.1073/pnas.2316823120

PMCID:: PMC10740390

Abstract Article PDF–6.3M

Select item 103292845.

A mitochondrial iron-responsive pathway regulated by DELE1

Yusuke Sekine, Ryan Houston, Eva-Maria Eckl, Evelyn Fessler, Derek P Narendra, Lucas T Jae, Shiori Sekine

Mol Cell. Author manuscript; available in PMC 2024 Jun 15.

Published in final edited form as: Mol Cell. 2023 Jun 15; 83(12): 2059–2076.e6. doi: 10.1016/j.molcel.2023.05.031

PMCID:: PMC10329284

Abstract Article PDF–3.2M

Select item 102374226.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101488437.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y

PMCID:: PMC10148843

Abstract Article PDF–11M

Select item 100058988.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 99064289.

LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease

Mi Bai, Mengqiu Wu, Mingzhu Jiang, Jia He, Xu Deng, Shuang Xu, Jiaojiao Fan, Mengqiu Miao, Ting Wang, Yuting Li, Xiaowen Yu, Lin Wang, Yue Zhang, Songming Huang, Li Yang, Zhanjun Jia, Aihua Zhang

EMBO Mol Med. 2023 Feb; 15(2): e16581. Published online 2023 Jan 11. doi: 10.15252/emmm.202216581

PMCID:: PMC9906428

Abstract Article PDF–14M

Select item 989940510.

Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination

Liyi Wu, Xinyi Yan, Ruibo Sun, Ye Ma, Wanyu Yao, Baogui Gao, Qingyuan Zhang, Junxiong You, Hao Wang, Qinrui Han, Xuegang Sun

J Transl Med. 2023; 21: 81. Published online 2023 Feb 4. doi: 10.1186/s12967-023-03925-x

PMCID:: PMC9899405

Abstract Article PDF–2.2M

Select item 973930811.

Differential Expression of Lonp1 Isoforms in Cancer Cells

Giada Zanini, Valentina Selleri, Anna De Gaetano, Lara Gibellini, Mara Malerba, Anna Vittoria Mattioli, Milena Nasi, Nadezda Apostolova, Marcello Pinti

Cells. 2022 Dec; 11(23): 3940. Published online 2022 Dec 6. doi: 10.3390/cells11233940

PMCID:: PMC9739308

Abstract Article PDF–1.9M

Select item 965761012.

Roles of LonP1 in Oral-Maxillofacial Developmental Defects and Tumors: A Novel Insight

Haozhen Ma, Wanting Chen, Wenguo Fan, Hongwen He, Fang Huang

Int J Mol Sci. 2022 Nov; 23(21): 13370. Published online 2022 Nov 2. doi: 10.3390/ijms232113370

PMCID:: PMC9657610

Abstract Article PDF–1.7M

Select item 962962113.

Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications

Nitika, Bo Zheng, Linhao Ruan, Jake T. Kline, Siddhi Omkar, Jacek Sikora, Mara Texeira Torres, Yuhao Wang, Jade E. Takakuwa, Romain Huguet, Cinzia Klemm, Verónica A. Segarra, Matthew J. Winters, Peter M. Pryciak, Peter H. Thorpe, Kazuo Tatebayashi, Rong Li, Luca Fornelli, Andrew W. Truman

PLoS Biol. 2022 Oct; 20(10): e3001839. Published online 2022 Oct 21. doi: 10.1371/journal.pbio.3001839

PMCID:: PMC9629621

Abstract Article PDF–3.4M

Select item 962912114.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 955026615.

Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition

Ilaria Iacobucci, Vittoria Monaco, Luisa Canè, Francesca Bibbò, Valentina Cioffi, Flora Cozzolino, Alfredo Guarino, Massimo Zollo, Maria Monti

Front Mol Biosci. 2022; 9: 975570. Published online 2022 Sep 26. doi: 10.3389/fmolb.2022.975570

PMCID:: PMC9550266

Abstract Article PDF–2.5M

Select item 929078116.

A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease

Zhou Sha, Monica M. Montano, Kristy Rochon, Jason A. Mears, Daniel Deredge, Patrick Wintrode, Luke Szweda, Natalie Mikita, Irene Lee

Arch Biochem Biophys. Author manuscript; available in PMC 2022 Jul 18.

Published in final edited form as: Arch Biochem Biophys. 2021 Oct 15; 710: 108983. Published online 2021 Jul 3. doi: 10.1016/j.abb.2021.108983

PMCID:: PMC9290781

Abstract Article PDF–1.5M

Select item 927928517.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 922651018.

ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia

Linjiang Lao, Isabelle Bourdeau, Lucia Gagliardi, Xiao He, Wei Shi, Bingbing Hao, Minjia Tan, Yan Hu, Junzheng Peng, Benoit Coulombe, David J Torpy, Hamish S Scott, Andre Lacroix, Hongyu Luo, Jiangping Wu

Nucleic Acids Res. 2022 Jun 24; 50(11): 6343–6367. Published online 2022 Jun 10. doi: 10.1093/nar/gkac483