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Select item 88095121.

IL-37-induced activation of glycogen synthase kinase 3β promotes IL-1R8/Sigirr phosphorylation, internalization, and degradation in lung epithelial cells

Lian Li, Jianxin Wei, Tomeka L. Suber, Qinmao Ye, Jiaxing Miao, Shuang Li, Sarah J. Taleb, Kevin C. Tran, Arya S. Tamaskar, Jing Zhao, Yutong Zhao

J Cell Physiol. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: J Cell Physiol. 2021 Aug; 236(8): 5676–5685. Published online 2021 Jan 5. doi: 10.1002/jcp.30253

PMCID:: PMC8809512

Abstract Article PDF–1.6M

Select item 87489582.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 86881793.

SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut

Wei Yu, Inamul Haque, Aparna Venkatraman, Heather L. Menden, Sherry M. Mabry, Badal C. Roy, Sheng Xia, Jeremy W. Prokop, Shahid Umar, Aron M. Geurts, Venkatesh Sampath

Cell Mol Gastroenterol Hepatol. 2022; 13(2): 425–440. Published online 2021 Sep 23. doi: 10.1016/j.jcmgh.2021.09.009

PMCID:: PMC8688179

Abstract Article PDF–4.1M

Select item 81745414.

IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway

Chang Jia, Yingzhi Zhuge, Shuchi Zhang, Chao Ni, Linlin Wang, Rongzhou Wu, Chao Niu, Zhengwang Wen, Xing Rong, Huixian Qiu, Maoping Chu

Cell Death Dis. 2021 Jun; 12(6): 575. Published online 2021 Jun 3. doi: 10.1038/s41419-021-03852-z

Correction in:: Cell Death Dis. 2021 Aug; 12(8): 759.

PMCID:: PMC8174541

Abstract Article PDF–2.6M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81240006.

Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis

Xiaoke Yang, Mingyue Zhang, Shengqian Xu, Haifeng Pan, Ruixue Leng, Zongwen Shuai

Biomed Res Int. 2021; 2021: 6683148. Published online 2021 May 7. doi: 10.1155/2021/6683148

PMCID:: PMC8124000

Abstract Article PDF–415K

Select item 76810997.

IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8

Alba Sánchez-Fernández, Stephanie Zandee, Jesús Amo-Aparicio, Marc Charabati, Alexandre Prat, Cecilia Garlanda, Elan Z. Eisenmesser, Charles A. Dinarello, Rubèn López-Vales

Theranostics. 2021; 11(1): 1–13. Published online 2021 Jan 1. doi: 10.7150/thno.47435

PMCID:: PMC7681099

Abstract Article PDF–1.4M

Select item 75849448.

Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro

Feng Tian, Qiang Lu, Jie Lei, Yunfeng Ni, Nianlin Xie, Daixing Zhong, Guang Yang, Shaokui Si, Tao Jiang

J Immunol Res. 2020; 2020: 5097920. Published online 2020 Oct 15. doi: 10.1155/2020/5097920

PMCID:: PMC7584944

Abstract Article PDF–1.6M

Select item 74536629.

Single immunoglobulin and Toll-interleukin-1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll-like receptor-4 signaling pathway: A clinical and experimental study

Rulin Zhao, Conghua Song, Li Liu, Qiong Liu, Nanjin Zhou, Xiaojiang Zhou, Yong Xie

Mol Med Rep. 2020 Oct; 22(4): 2851–2859. Published online 2020 Jul 28. doi: 10.3892/mmr.2020.11379

PMCID:: PMC7453662

Abstract Article PDF–567K

Select item 709486210.

Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR

Mufadhal Al-Kuhlani, Graham Lambert, Sukumar Pal, Luis de la Maza, David M. Ojcius

PLoS One. 2020; 15(3): e0230718. Published online 2020 Mar 25. doi: 10.1371/journal.pone.0230718

PMCID:: PMC7094862

Abstract Article PDF–1.1M

Select item 638658811.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 556478212.

High IL-1R8 expression in breast tumors promotes tumor growth and contributes to impaired antitumor immunity

Luis Felipe Campesato, Ana Paula M. Silva, Luna Cordeiro, Bruna R. Correa, Fabio C.P. Navarro, Rafael F. Zanin, Marina Marçola, Lilian T. Inoue, Mariana L. Duarte, Martina Molgora, Fabio Pasqualini, Matteo Massara, Pedro Galante, Romualdo Barroso-Sousa, Nadia Polentarutti, Federica Riva, Erico T. Costa, Alberto Mantovani, Cecilia Garlanda, Anamaria A. Camargo

Oncotarget. 2017 Jul 25; 8(30): 49470–49483. Published online 2017 May 9. doi: 10.18632/oncotarget.17713

PMCID:: PMC5564782

Abstract Article PDF–7.7M

Select item 549522513.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 530844714.

Human Colon Tumors Express a Dominant-negative Form of SIGIRR That Promotes Inflammation and Colitis-associated Colon Cancer in Mice

Junjie Zhao, Katarzyna Bulek, Muhammet Fatih Gulen, Jarod A. Zepp, Georgio Karagkounis, Bradley N Martin, Hao Zhou, Minjia Yu, Xiuli Liu, Emina Huang, Paul L. Fox, Matthew F. Kalady, Sanford D. Markowitz, Xiaoxia Li

Gastroenterology. Author manuscript; available in PMC 2017 Feb 14.

Published in final edited form as: Gastroenterology. 2015 Dec; 149(7): 1860–1871.e8. Published online 2015 Sep 5. doi: 10.1053/j.gastro.2015.08.051

PMCID:: PMC5308447

Abstract Article PDF–2.1M

Select item 466962015.

SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells

Dan Li, Xin Zhang, Baiyi Chen

BMC Immunol. 2015; 16: 73. Published online 2015 Dec 3. doi: 10.1186/s12865-015-0137-5

PMCID:: PMC4669620

Abstract Article PDF–2.6M

Select item 466109816.

SIGIRR/TIR8, an important regulator of TLR4 and IL-1R-mediated NF-kB activation, predicts biochemical recurrence after prostatectomy in low-grade prostate carcinomas

Tyler M. Bauman, Alexander J. Becka, Priyanka D. Sehgal, Wei Huang, William A. Ricke

Hum Pathol. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Hum Pathol. 2015 Nov; 46(11): 1744–1751. Published online 2015 Jul 29. doi: 10.1016/j.humpath.2015.07.015

PMCID:: PMC4661098

Abstract Article PDF–530K

Select item 444480017.

SIGIRR Genetic Variants in Premature Infants With Necrotizing Enterocolitis

Venkatesh Sampath, Heather Menden, Daniel Helbling, Keguo Li, Adam Gastonguay, Ramani Ramchandran, David P. Dimmock

Pediatrics. 2015 Jun; 135(6): e1530–e1534. doi: 10.1542/peds.2014-3386

PMCID:: PMC4444800

Abstract Article PDF–689K

Select item 434560818.

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

Suzhao Li, C. Preston Neff, Kristina Barber, Jaewoo Hong, Yuchun Luo, Tania Azam, Brent E. Palmer, Mayumi Fujita, Cecilia Garlanda, Alberto Mantovani, Soohyun Kim, Charles Anthony Dinarello

Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8): 2497–2502. Published online 2015 Feb 5. doi: 10.1073/pnas.1424626112

PMCID:: PMC4345608

Abstract Article PDF–1.2M

Select item 414026119.

Lipopolysaccharide Decreases Single Immunoglobulin Interleukin-1 Receptor-related Molecule (SIGIRR) Expression by Suppressing Specificity Protein 1 (Sp1) via the Toll-like Receptor 4 (TLR4)-p38 Pathway in Monocytes and Neutrophils

Keiko Ueno-Shuto, Kosuke Kato, Yukihiro Tasaki, Miki Sato, Keizo Sato, Yuji Uchida, Hiromichi Sakai, Tomomi Ono, Mary Ann Suico, Kazunori Mitsutake, Naofumi Tokutomi, Hirofumi Kai, Tsuyoshi Shuto

J Biol Chem. 2014 Jun 27; 289(26): 18097–18109. Published online 2014 May 12. doi: 10.1074/jbc.M113.532093

PMCID:: PMC4140261

Abstract Article PDF–3.2M

Select item 365255220.

The Single IgG IL-1 related receptor (Sigirr) controls Toll-like receptor responses in differentiated human intestinal epithelial cells

Mohammed A. Khan, Ho Pan Sham, Kirk Bergstrom, Jingtian T. Huang, Theodore S. Steiner, Kiran Assi, Bill Salh, Isabella T. Tai, Xiaoxia Li, Bruce A. Vallance

J Immunol. Author manuscript; available in PMC 2013 May 13.

Published in final edited form as: J Immunol. 2010 Mar 1; 184(5): 2305–2313. Published online 2010 Feb 3. doi: 10.4049/jimmunol.0900021

PMCID:: PMC3652552

Abstract Article PDF–3.5M

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PMC Links for GEO Profiles (Select 131393954) (30)
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Influenza A effect on plasmacytoid dendritic cells
Influenza A effect on plasmacytoid dendritic cells
Accession: GDS6063

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HOXB2 [Centrocercus urophasianus]
HOXB2 [Centrocercus urophasianus]
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