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Select item 111862881.

Evidence for a relationship between genetic polymorphisms of the L-DOPA transporter LAT2/4F2hc and risk of hypertension in the context of chronic kidney disease

Paolina Crocco, Serena Dato, Rossella La Grotta, Giuseppe Passarino, Giuseppina Rose

BMC Med Genomics. 2024; 17: 163. Published online 2024 Jun 18. doi: 10.1186/s12920-024-01935-2

PMCID:: PMC11186288

Abstract Article PDF–755K

Select item 108663992.

SLC7A8 overexpression inhibits the growth and metastasis of lung adenocarcinoma and is correlated with a dismal prognosis

Fang-Ming Wang, Li-Qiang Xu, Zhong-Chao Zhang, Qiang Guo, Zhi-Peng Du, Yue Lei, Xu Han, Chuang-Yan Wu, Feng Zhao, Jiu-Ling Chen

Aging (Albany NY) 2024 Jan 31; 16(2): 1605–1619. Published online 2024 Jan 18. doi: 10.18632/aging.205446

PMCID:: PMC10866399

Abstract Article PDF–2.3M

Select item 97506663.

Identification and verification of microRNA signature and key genes in the development of osteosarcoma with lung metastasis

Fanjian Meng, Lulu Wang, Guangyu Gao, Jinpeng Chen, Xinghua Wang, Gaochen Wu, Yiqi Miu

Medicine (Baltimore) 2022 Dec 9; 101(49): e32258. Published online 2022 Dec 9. doi: 10.1097/MD.0000000000032258

PMCID:: PMC9750666

Abstract Article PDF–1.8M

Select item 84923454.

Genomic and epigenomic evolution of acquired resistance to combination therapy in esophageal squamous cell carcinoma

Qingjie Min, Yan Wang, Qingnan Wu, Xianfeng Li, Huajing Teng, Jiawen Fan, Yiren Cao, Pingsheng Fan, Qimin Zhan

JCI Insight. 2021 Sep 8; 6(17): e150203. Published online 2021 Sep 8. doi: 10.1172/jci.insight.150203

PMCID:: PMC8492345

Abstract Article PDF–1.4M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76870086.

Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno‐foetal amino acid transport

Jonas Zaugg, Xiao Huang, Fabian Ziegler, Matthias Rubin, Julien Graff, Jennifer Müller, Ruedi Moser‐Hässig, Theresa Powell, Jürg Gertsch, Karl‐Heinz Altmann, Christiane Albrecht

J Cell Mol Med. 2020 Nov; 24(21): 12681–12693. Published online 2020 Oct 1. doi: 10.1111/jcmm.15840

PMCID:: PMC7687008

Abstract Article PDF–1.3M

Select item 76539417.

Structural insight into the substrate recognition and transport mechanism of the human LAT2–4F2hc complex

Renhong Yan, Jiayao Zhou, Yaning Li, Jianlin Lei, Qiang Zhou

Cell Discov. 2020; 6: 82. Published online 2020 Nov 10. doi: 10.1038/s41421-020-00207-4

PMCID:: PMC7653941

Article PDF–711K

Select item 75897578.

The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2

Satish Kantipudi, Jean-Marc Jeckelmann, Zöhre Ucurum, Patrick D. Bosshart, Dimitrios Fotiadis

Int J Mol Sci. 2020 Oct; 21(20): 7573. Published online 2020 Oct 14. doi: 10.3390/ijms21207573

PMCID:: PMC7589757

Abstract Article PDF–1.3M

Select item 75840349.

Sub-Nanometer Cryo-EM Density Map of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2

Jean-Marc Jeckelmann, Dimitrios Fotiadis

Int J Mol Sci. 2020 Oct; 21(19): 7094. Published online 2020 Sep 25. doi: 10.3390/ijms21197094

PMCID:: PMC7584034

Abstract Article PDF–4.0M

Select item 718263410.

The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer

Rokaya El Ansari, Lutfi Alfarsi, Madeleine L. Craze, Brendah K. Masisi, Ian O. Ellis, Emad A. Rakha, Andrew R. Green

Breast Cancer Res Treat. 2020; 181(1): 1–12. Published online 2020 Mar 21. doi: 10.1007/s10549-020-05586-6

PMCID:: PMC7182634

Abstract Article PDF–1.7M

Select item 716998311.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 697825712.

Abnormalities in the genes that encode Large Amino Acid Transporters increase the risk of Autism Spectrum Disorder

Lauren Cascio, Chin‐Fu Chen, Rini Pauly, Sujata Srikanth, Kelly Jones, Cindy D. Skinner, Roger E. Stevenson, Charles E. Schwartz, Luigi Boccuto

Mol Genet Genomic Med. 2020 Jan; 8(1): e1036. Published online 2019 Nov 7. doi: 10.1002/mgg3.1036

PMCID:: PMC6978257

Abstract Article PDF–826K

Select item 633509913.

Blood-Brain Barrier: From Physiology to Disease and Back

Melanie D. Sweeney, Zhen Zhao, Axel Montagne, Amy R. Nelson, Berislav V. Zlokovic

Physiol Rev. 2019 Jan 1; 99(1): 21–78. Published online 2018 Oct 3. doi: 10.1152/physrev.00050.2017

PMCID:: PMC6335099

Abstract Article

Select item 623356514.

LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

Mengyu Feng, Guangbing Xiong, Zhe Cao, Gang Yang, Suli Zheng, Jiangdong Qiu, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao

J Exp Clin Cancer Res. 2018; 37: 274. Published online 2018 Nov 12. doi: 10.1186/s13046-018-0947-4

PMCID:: PMC6233565

Abstract Article PDF–8.1M

Select item 581121515.

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

Meritxell Espino Guarch, Mariona Font-Llitjós, Silvia Murillo-Cuesta, Ekaitz Errasti- Murugarren, Adelaida M Celaya, Giorgia Girotto, Dragana Vuckovic, Massimo Mezzavilla, Clara Vilches, Susanna Bodoy, Ignasi Sahún, Laura González, Esther Prat, Antonio Zorzano, Mara Dierssen, Isabel Varela-Nieto, Paolo Gasparini, Manuel Palacín, Virginia Nunes

eLife. 2018; 7: e31511. Published online 2018 Jan 22. doi: 10.7554/eLife.31511

PMCID:: PMC5811215

Abstract Article PDF–4.3M

Select item 488030316.

Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors

Susi Barollo, Loris Bertazza, Sara Watutantrige-Fernando, Simona Censi, Elisabetta Cavedon, Francesca Galuppini, Gianmaria Pennelli, Ambrogio Fassina, Marilisa Citton, Beatrice Rubin, Raffaele Pezzani, Clara Benna, Giuseppe Opocher, Maurizio Iacobone, Caterina Mian

PLoS One. 2016; 11(5): e0156044. Published online 2016 May 25. doi: 10.1371/journal.pone.0156044

PMCID:: PMC4880303

Abstract Article PDF–3.1M

Select item 446207917.

Expression and functional characterisation of System L amino acid transporters in the human term placenta

Francesca Gaccioli, Irving L. M. H. Aye, Sara Roos, Susanne Lager, Vanessa I. Ramirez, Yoshikatsu Kanai, Theresa L. Powell, Thomas Jansson

Reprod Biol Endocrinol. 2015; 13: 57. Published online 2015 Jun 9. doi: 10.1186/s12958-015-0054-8

PMCID:: PMC4462079

Abstract Article PDF–1.3M

Select item 419258618.

Detergent-Induced Stabilization and Improved 3D Map of the Human Heteromeric Amino Acid Transporter 4F2hc-LAT2

Marcel Meury, Meritxell Costa, Daniel Harder, Mirko Stauffer, Jean-Marc Jeckelmann, Béla Brühlmann, Albert Rosell, Hüseyin Ilgü, Karin Kovar, Manuel Palacín, Dimitrios Fotiadis

PLoS One. 2014; 9(10): e109882. Published online 2014 Oct 9. doi: 10.1371/journal.pone.0109882

PMCID:: PMC4192586

Abstract Article PDF–1.0M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311255820.

The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation

S-Y Chan, A Martín-Santos, L S Loubière, A M González, B Stieger, A Logan, C J McCabe, J A Franklyn, M D Kilby

J Physiol. 2011 Jun 1; 589(Pt 11): 2827–2845. Published online 2011 Mar 21. doi: 10.1113/jphysiol.2011.207290

PMCID:: PMC3112558

Abstract Article PDF–564K

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