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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 104068362.

CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma

You Heng Chuah, Emmy Xue Yun Tay, Oleg V. Grinchuk, Jeehyun Yoon, Jia Feng, Srinivasaraghavan Kannan, Matius Robert, Rekha Jakhar, Yajing Liang, Bernice Woon Li Lee, Loo Chien Wang, Yan Ting Lim, Tianyun Zhao, Radoslaw M. Sobota, Guang Lu, Boon Chuan Low, Karen Carmelina Crasta, Chandra Shekhar Verma, Zhewang Lin, Derrick Sek Tong Ong

Cell Death Differ. 2023 Aug; 30(8): 1973–1987. Published online 2023 Jul 19. doi: 10.1038/s41418-023-01192-3

PMCID:: PMC10406836

Abstract Article PDF–5.9M

Select item 102058583.

USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination

Binggong Zhao, Wei Huo, Xiaomin Yu, Xiaoxia Shi, Linlin Lv, Yuxi Yang, Jie Kang, Shujing Li, Huijian Wu

Cell Oncol (Dordr) 2023; 46(3): 717–733. Published online 2023 Feb 3. doi: 10.1007/s13402-023-00779-9

PMCID:: PMC10205858

Abstract Article PDF–15M

Select item 101951494.

RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity: The role of RNF8 in EMT and drug sensitivity in HCC

Jingyu Kuang, Ting Duan, Changsong Gao, Chuanyang Liu, Si Chen, Lv-yun Zhu, Lu Min, Chenyu Lu, Wenlun Wang, Lingyun Zhu

Acta Biochim Biophys Sin (Shanghai) 2023 Apr; 55(4): 661–671. Published online 2023 May 6. doi: 10.3724/abbs.2023076

PMCID:: PMC10195149

Abstract Article PDF–2.7M

Select item 92792855.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92778536.

A functional reference map of the RNF8 interactome in cancer

Chuanyang Liu, Jingyu Kuang, Yuxuan Wang, Ting Duan, Lu Min, Chenyu Lu, Tianyi Zhang, Ruifen Chen, Ying Wu, Lingyun Zhu

Biol Direct. 2022; 17: 17. Published online 2022 Jul 13. doi: 10.1186/s13062-022-00331-z

PMCID:: PMC9277853

Abstract Article PDF–5.9M

Select item 90128847.

RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression

Tingting Zhou, Shengli Wang, Xiaoyu Song, Wensu Liu, Fang Dong, Yunlong Huo, Renlong Zou, Chunyu Wang, Siyi Zhang, Wei Liu, Ge Sun, Lin Lin, Kai Zeng, Xiang Dong, Qiqiang Guo, Fei Yi, Zhuo Wang, Xiaoman Li, Bo Jiang, Liu Cao, Yue Zhao

Cell Death Dis. 2022 Apr; 13(4): 352. Published online 2022 Apr 15. doi: 10.1038/s41419-022-04787-9

PMCID:: PMC9012884

Abstract Article PDF–5.8M

Select item 88970228.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 83529649.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 824203210.

Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance

Qinglei Hang, Liyong Zeng, Li Wang, Litong Nie, Fan Yao, Hongqi Teng, Yalan Deng, Shannon Yap, Yutong Sun, Steven J. Frank, Junjie Chen, Li Ma

Nat Commun. 2021; 12: 4033. Published online 2021 Jun 29. doi: 10.1038/s41467-021-24298-z

PMCID:: PMC8242032

Abstract Article PDF–4.8M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 793596512.

RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks

Qunsong Tan, Kaifeng Niu, Yuqi Zhu, Zixiang Chen, Yueyang Li, Mengge Li, Di Wei, Adayabalam S. Balajee, Hongbo Fang, Yongliang Zhao

Oncogenesis. 2021 Mar; 10(3): 24. Published online 2021 Mar 5. doi: 10.1038/s41389-021-00315-0

PMCID:: PMC7935965

Abstract Article PDF–1.8M

Select item 789840913.

The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple‐negative breast cancer cells

Bruno Pereira De Carvalho, Yi‐Jye Chern, Jiabei He, Chia‐Hsin Chan

FEBS Lett. 2021 Jan; 595(2): 241–252. Published online 2020 Dec 5. doi: 10.1002/1873-3468.13999

PMCID:: PMC7898409

Abstract Article PDF–2.2M

Select item 781571914.

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP_L

Osamu Nakabayashi, Hirotaka Takahashi, Kenta Moriwaki, Sachiko Komazawa-Sakon, Fumiaki Ohtake, Shin Murai, Yuichi Tsuchiya, Yuki Koyahara, Yasushi Saeki, Yukiko Yoshida, Soh Yamazaki, Fuminori Tokunaga, Tatsuya Sawasaki, Hiroyasu Nakano

Commun Biol. 2021; 4: 80. Published online 2021 Jan 19. doi: 10.1038/s42003-020-01603-y

PMCID:: PMC7815719

Abstract Article PDF–4.3M

Select item 759806915.

Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors

Lulu Wang, Lin Yang, Chen Wang, Wei Zhao, Zhenlin Ju, Wei Zhang, Jianfeng Shen, Yang Peng, Clemens An, Yen T. Luu, Shumei Song, Timothy A. Yap, Jaffer A. Ajani, Gordon B. Mills, Xuetong Shen, Guang Peng

J Clin Invest. 2020 Nov 2; 130(11): 5951–5966. Published online 2020 Oct 5. doi: 10.1172/JCI130445

PMCID:: PMC7598069

Abstract Article PDF–8.7M

Select item 729495216.

RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation

Ling Ren, Tingting Zhou, Yang Wang, Yanmei Wu, Hongde Xu, Jingwei Liu, Xiang Dong, Fei Yi, Qiqiang Guo, Zhuo Wang, Xiaoman Li, Ning Bai, Wendong Guo, Min Guo, Bo Jiang, Xuan Wu, Yanling Feng, Xiaoyu Song, Siyi Zhang, Yue Zhao, Liu Cao, Shuai Han, Chengzhong Xing

Int J Biol Sci. 2020; 16(12): 2051–2062. Published online 2020 May 1. doi: 10.7150/ijbs.44119

PMCID:: PMC7294952

Abstract Article PDF–2.1M

Select item 729302217.

RNF8 has both KU-dependent and independent roles in chromosomal break repair

Linda Jillianne Tsai, Felicia Wednesday Lopezcolorado, Ragini Bhargava, Carlos Mendez-Dorantes, Eva Jahanshir, Jeremy M Stark

Nucleic Acids Res. 2020 Jun 19; 48(11): 6032–6052. Published online 2020 May 19. doi: 10.1093/nar/gkaa380

PMCID:: PMC7293022

Abstract Article PDF–4.3M

Select item 727447018.

RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia

Huijun Zhi, Xin Guo, Yik-Khuan Ho, Nagesh Pasupala, Hampus Alexander Anders Engstrom, Oliver John Semmes, Chou-Zen Giam

PLoS Pathog. 2020 May; 16(5): e1008618. Published online 2020 May 26. doi: 10.1371/journal.ppat.1008618

PMCID:: PMC7274470

Abstract Article PDF–2.2M

Select item 716998319.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 710696420.

RNF8 promotes efficient DSB repair by inhibiting the pro‐apoptotic activity of p53 through regulating the function of Tip60

Hongyu Chen, Jin Shan, Jialing Liu, Yunpeng Feng, Yueshuang Ke, Wenjing Qi, Wenguang Liu, Xianlu Zeng

Cell Prolif. 2020 Mar; 53(3): e12780. Published online 2020 Feb 7. doi: 10.1111/cpr.12780

PMCID:: PMC7106964

Abstract Article PDF–2.2M

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