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Select item 111907181.

MiR-106a-5p targets PFKFB3 and improves sepsis through regulating macrophage pyroptosis and inflammatory response

Yixin Chen, Ping Zhang, Fangwei Han, Yanying Zhou, Juexian Wei, Cailing Wang, Mingchuan Song, Shaopeng Lin, Yiming Xu, Xiaohui Chen

J Biol Chem. 2024 Jun; 300(6): 107334. Published online 2024 May 3. doi: 10.1016/j.jbc.2024.107334

PMCID:: PMC11190718

Abstract Article PDF–6.2M

Select item 110176152.

Multi-omics and immunogenomics analysis revealed PFKFB3 as a targetable hallmark and mediates sunitinib resistance in papillary renal cell carcinoma: in silico study with laboratory verification

Zhongwen Lu, Yongsheng Pan, Songbo Wang, Jiajin Wu, Chenkui Miao, Zengjun Wang

Eur J Med Res. 2024; 29: 236. Published online 2024 Apr 15. doi: 10.1186/s40001-024-01808-5

PMCID:: PMC11017615

Abstract Article PDF–12M

Select item 108611473.

Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition

Baixue Yu, Kaiyuan Shen, Tingting Li, Jiawei Li, Mei Meng, Wenjie Liu, Qunye Tang, Tongyu Zhu, Xin Wang, Susan W. S. Leung, Yi Shi

Am J Physiol Cell Physiol. 2023 Nov 1; 325(5): C1354–C1368. Published online 2023 Oct 2. doi: 10.1152/ajpcell.00261.2023

PMCID:: PMC10861147

Abstract Article

Select item 107826434.

Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis

Xin Tracy Liu, Yu Huang, Da Liu, Yingxin Celia Jiang, Min Zhao, Long Hoa Chung, Xingxing Daisy Han, Yinan Zhao, Jinbiao Chen, Paul Coleman, Ka Ka Ting, Collin Tran, Yingying Su, Claude Vincent Dennis, Atul Bhatnagar, Ken Liu, Anthony Simon Don, Mathew Alexander Vadas, Mark Douglas Gorrell, Shubiao Zhang, Michael Murray, Mary Meltem Kavurma, Geoffrey William McCaughan, Jennifer Ruth Gamble, Yanfei Qi

J Transl Med. 2024; 22: 43. Published online 2024 Jan 10. doi: 10.1186/s12967-023-04830-z

PMCID:: PMC10782643

Abstract Article PDF–7.3M

Select item 102580275.

Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers

Qingen Da, Lei Huang, Can Huang, Zee Chen, Zhitong Jiang, Fang Huang, Tao Shen, Lu Sun, Zilong Yan, Xiaoqiang Ye, Jing Yi, Yu Huang, JingJing Da, Mingming Ren, Jikui Liu, Tao Wang, Zhen Han, Kunfu Ouyang

Aging (Albany NY) 2023 May 31; 15(10): 4533–4559. Published online 2023 May 30. doi: 10.18632/aging.204758

PMCID:: PMC10258027

Abstract Article PDF–8.3M

Select item 100770486.

Deubiquitinase USP33 promotes the glycolysis and growth of osteosarcoma by modifying PFKFB3 ubiquitination and degradation

Bin Zhou, Nanye Wang, Qirui Chen, Juntao Ren, Xiaoling Fu, Xigao Cheng

Am J Cancer Res. 2023; 13(3): 922–935. Published online 2023 Mar 15.

PMCID:: PMC10077048

Abstract Article PDF–2.6M

Select item 100443957.

Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation

Xiao Cheng, Xiupeng Jia, Chunnian Wang, Shangyan Zhou, Jiayi Chen, Lei Chen, Jinping Chen

World J Surg Oncol. 2023; 21: 112. Published online 2023 Mar 28. doi: 10.1186/s12957-023-02990-2

PMCID:: PMC10044395

Abstract Article PDF–2.6M

Select item 98870478.

PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

Irina Larionova, Marina Patysheva, Pavel Iamshchikov, Elena Kazakova, Anna Kazakova, Militsa Rakina, Evgeniya Grigoryeva, Anna Tarasova, Sergei Afanasiev, Natalia Bezgodova, Artem Kiselev, Alexey Dobrodeev, Dmitriy Kostromitskiy, Nadezhda Cherdyntseva, Julia Kzhyshkowska

Front Immunol. 2022; 13: 1080501. Published online 2023 Jan 17. doi: 10.3389/fimmu.2022.1080501

PMCID:: PMC9887047

Abstract Article PDF–10M

Select item 98519739.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 972267010.

KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells

Xinhua Zhang, Bin Zheng, Lingdan Zhao, Jiayi Shen, Zhan Yang, Yu Zhang, Ruirui Fan, Manli Zhang, Dong Ma, Lemin Zheng, Mingming Zhao, Huirong Liu, Jinkun Wen

Commun Biol. 2022; 5: 1332. Published online 2022 Dec 5. doi: 10.1038/s42003-022-04302-y

PMCID:: PMC9722670

Abstract Article PDF–4.4M

Select item 967019011.

Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation

Zhou Zhou, Leonie G. Plug, Thiago A. Patente, Eveline S. M. de Jonge-Muller, Amir Abou Elmagd, Andrea E. van der Meulen-de Jong, Bart Everts, Marieke C. Barnhoorn, Lukas J. A. C. Hawinkels

Front Immunol. 2022; 13: 966067. Published online 2022 Nov 2. doi: 10.3389/fimmu.2022.966067

PMCID:: PMC9670190

Abstract Article PDF–16M

Select item 952364512.

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang, Zhe Han

Commun Biol. 2022; 5: 1039. Published online 2022 Sep 30. doi: 10.1038/s42003-022-03986-6

PMCID:: PMC9523645

Abstract Article PDF–3.9M

Select item 951953713.

PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM

Sayantani Sarkar Bhattacharya, Prabhu Thirusangu, Ling Jin, Julie Staub, Viji Shridhar, Julian R. Molina

Br J Cancer. 2022 Oct 19; 127(7): 1352–1364. Published online 2022 Jul 6. doi: 10.1038/s41416-022-01867-7

PMCID:: PMC9519537

Abstract Article PDF–4.8M

Select item 948263314.

PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma

Emma Phillips, Jörg Balss, Frederic Bethke, Stefan Pusch, Stefan Christen, Thomas Hielscher, Martina Schnölzer, Michael N. C. Fletcher, Antje Habel, Claudia Tessmer, Lisa-Marie Brenner, Mona Göttmann, David Capper, Christel Herold-Mende, Andreas von Deimling, Sarah-Maria Fendt, Violaine Goidts

Oncogenesis. 2022 Dec; 11(1): 57. Published online 2022 Sep 17. doi: 10.1038/s41389-022-00433-3

PMCID:: PMC9482633

Abstract Article PDF–3.4M

Select item 937459315.

PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma

Prabhu Thirusangu, Upasana Ray, Sayantani Sarkar Bhattacharya, Derek B. Oien, Ling Jin, Julie Staub, Nagarajan Kannan, Julian R. Molina, Viji Shridhar

Oncogene. 2022; 41(33): 4003–4017. Published online 2022 Jul 8. doi: 10.1038/s41388-022-02391-x