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Select item 112342681.

Lens autophagy protein ATG16L1: a potential target for cataract treatment

Yilei Cui, Xiaoning Yu, Jing Bao, Xiyuan Ping, Silu Shi, Yuxin Huang, Qichuan Yin, Hao Yang, Ruoqi Chen, Ke Yao, Xiangjun Chen, Xingchao Shentu

Theranostics. 2024; 14(10): 3984–3996. Published online 2024 Jul 1. doi: 10.7150/thno.93864

PMCID:: PMC11234268

Abstract Article PDF–7.6M

Select item 109790312.

Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection

Renée R. C. E. Schreurs, Athanasios Koulis, Thijs Booiman, Brigitte Boeser-Nunnink, Alexandra P. M. Cloherty, Anusca G. Rader, Kharishma S. Patel, Neeltje A. Kootstra, Carla M. S. Ribeiro

Nat Commun. 2024; 15: 2465. Published online 2024 Mar 28. doi: 10.1038/s41467-024-46606-z

PMCID:: PMC10979031

Abstract Article PDF–3.6M

Select item 108597133.

ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta‐analysis on inflammatory bowel disease risk and clinical outcomes

Isidora Simovic, Ida Hilmi, Ruey Terng Ng, Kee Seang Chew, Shin Yee Wong, Way Seah Lee, Stephen Riordan, Natalia Castaño‐Rodríguez

United European Gastroenterol J. 2024 Feb; 12(1): 103–121. Published online 2023 Oct 14. doi: 10.1002/ueg2.12477

PMCID:: PMC10859713

Abstract Article PDF–1.1M

Select item 107915584.

The V-ATPase–ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response

Tomoya Eguchi, Maria Sakurai, Yingxue Wang, Chieko Saito, Gen Yoshii, Thomas Wileman, Noboru Mizushima, Tomoki Kuwahara, Takeshi Iwatsubo

J Cell Biol. 2024 Mar 4; 223(3): e202302067. Published online 2024 Jan 16. doi: 10.1083/jcb.202302067

PMCID:: PMC10791558

Abstract Article PDF–5.8M

Select item 107430145.

Comparative Genetic Analysis of the Promoters of the ATG16L1 and ATG5 Genes Associated with Sporadic Parkinson’s Disease

Ana Gómez-Martín, José M. Fuentes, Joaquín Jordán, María F. Galindo, José Luis Fernández-García

Genes (Basel) 2023 Dec; 14(12): 2171. Published online 2023 Dec 2. doi: 10.3390/genes14122171

PMCID:: PMC10743014

Abstract Article PDF–1.6M

Select item 106882626.

Coiled-coil-mediated dimerization of Atg16 is required for binding to the PROPPIN Atg21

Miranda Bueno-Arribas, Celia Cruz-Cuevas, María-Angeles Navas, Ricardo Escalante, Olivier Vincent

Open Biol. 2023 Nov; 13(11): 230192. Published online November 22, 2023. doi: 10.1098/rsob.230192

PMCID:: PMC10688262

Abstract Article PDF–1.8M

Select item 105658767.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102628118.

TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection

Jie Wang, Xiao Qin, Yulu Huang, Qunmei Zhang, Jinyong Pei, Yi Wang, Idan Goren, Shujun Ma, Zhishan Song, Yanzi Liu, Hongxia Xing, Hui Wang, Bo Yang

Autophagy. 2023; 19(6): 1844–1862. Published online 2023 Jan 1. doi: 10.1080/15548627.2022.2162706

PMCID:: PMC10262811

Abstract Article PDF–7.7M

Select item 102582859.

Genetic Polymorphisms of NOD2 and ATG16L1 in Different Types of Digestive Tract Inflammation

Mushtaq Hashim Al-Bderee N, Faaz Nassir Al-Saad N, Jawad Al-Imari M, Mudhaher Habbeb S, Mizal Azoz A

Arch Razi Inst. 2023 Feb; 78(1): 493–498. Published online 2023 Feb 28. doi: 10.22092/ARI.2022.359754.2473

PMCID:: PMC10258285

Abstract Article PDF–381K

Select item 1023742210.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 997567911.

Association of PNPLA3 (rs738409) & TM6SF2 (rs58542926) and ATG16L1 (rs2241880) genetic variants with susceptibility to hepatocellular carcinoma in a group of Egyptian patients with HCV-induced liver cirrhosis

Asmaa Mohamed Fteah, Ali Abdel Rahim, Afaf Ahmed AbdelHady, Hanan Shawky, Mohamed A Elrefaiy, Doaa Mamdouh Aly

Tumour Virus Res. 2023 Jun; 15: 200256. Published online 2023 Feb 16. doi: 10.1016/j.tvr.2023.200256

PMCID:: PMC9975679

Article PDF–493K

Select item 971371812.

Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection

Subhash Mehto, Kautilya Kumar Jena, Rina Yadav, Swatismita Priyadarsini, Pallavi Samal, Sivaram Krishna, Kollori Dhar, Ashish Jain, Nishant Ranjan Chauhan, Krushna C Murmu, Ramyasingh Bal, Rinku Sahu, Pundrik Jaiswal, Bhabani Sankar Sahoo, Srinivas Patnaik, Thomas A Kufer, Tor Erik Rusten, Swati Chauhan, Punit Prasad, Santosh Chauhan

EMBO J. 2022 Dec; 41(23): e111289. Published online 2022 Oct 11. doi: 10.15252/embj.2022111289

PMCID:: PMC9713718

Abstract Article PDF–14M

Select item 967395013.

ATG16L1 WD40 domain-dependent IL10R (interleukin 10 receptor) signaling is insensitive to the T300A Crohn disease risk polymorphism

Inmaculada Serramito-Gómez, Elena Terraza-Silvestre, Álvaro Fernández-Cabrera, Raquel Villamuera, Felipe X. Pimentel-Muiños

Autophagy. 2022; 18(12): 3023–3030. Published online 2022 Mar 29. doi: 10.1080/15548627.2022.2054241

PMCID:: PMC9673950

Abstract Article PDF–1.4M

Select item 953369214.

Altered splicing of ATG16‐L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non‐small cell lung cancer

Anne‐Sophie Hatat, Clara Benoit‐Pilven, Amélie Pucciarelli, Florence de Fraipont, Lucie Lamothe, Pascal Perron, Amandine Rey, Matteo Giaj Levra, Anne‐Claire Toffart, Didier Auboeuf, Beatrice Eymin, Sylvie Gazzeri

Mol Oncol. 2022 Oct; 16(19): 3490–3508. Published online 2022 Aug 30. doi: 10.1002/1878-0261.13229

PMCID:: PMC9533692

Abstract Article PDF–1.8M

Select item 945929415.

Associations between ATG16L1 gene polymorphism and antineutrophil cytoplasmic antibody‐associated vasculitis in the Chinese Guangxi population: A case–control study

Bing‐Mei Feng, Chao Xue, Hai‐Zheng Huang, Yu‐gan Lu, Tao Feng, Xue‐Yi Huang, Wei Li

J Clin Lab Anal. 2022 Sep; 36(9): e24642. Published online 2022 Aug 10. doi: 10.1002/jcla.24642

PMCID:: PMC9459294

Abstract Article PDF–365K

Select item 933152616.

Alterations of autophagic and innate immune responses by the Crohn’s disease-associated ATG16L1 mutation

Natsuki Okai, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Hajime Honjo, Masatoshi Kudo

World J Gastroenterol. 2022 Jul 14; 28(26): 3063–3070. Published online 2022 Jul 14. doi: 10.3748/wjg.v28.i26.3063

PMCID:: PMC9331526

Abstract Article PDF–563K

Select item 927928517.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 911973618.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983