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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 93428992.

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

Jacqueline J.T. Marshall, Joshua J. Cull, Hajed O. Alharbi, May Zaw Thin, Susanna T.E. Cooper, Christopher Barrington, Hannah Vanyai, Thomas Snoeks, Bernard Siow, Alejandro Suáarez-Bonnet, Eleanor Herbert, Daniel J. Stuckey, Angus J.M. Cameron, Fabrice Prin, Andrew C. Cook, Simon L. Priestnall, Sonia Chotani, Owen J. L. Rackham, Daniel N. Meijles, Tim Mohun, Angela Clerk, Peter J. Parker

Biochem J. 2022 Jul 15; 479(13): 1467–1486. Prepublished online 2022 Jun 22. Published online 2022 Jul 12. doi: 10.1042/BCJ20220281

PMCID:: PMC9342899

Abstract Article PDF–30M

Select item 90145593.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 88103974.

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

Elizabeth R. Murray, Shinelle Menezes, Jack C. Henry, Josie L. Williams, Lorena Alba-Castellón, Priththivika Baskaran, Ivan Quétier, Ami Desai, Jacqueline J.T. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward P. Carter, Kairbaan Hodivala-Dilke, Richard P. Grose, Hemant M. Kocher, Nuria Gavara, Oliver Pearce, Pedro Cutillas, John F. Marshall, Angus J.M. Cameron

Cell Rep. 2022 Jan 25; 38(4): 110227. Published online 2022 Jan 25. doi: 10.1016/j.celrep.2021.110227

PMCID:: PMC8810397

Abstract Article

Select item 85535585.

Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation

Young-June Jin, Ramesh Chennupati, Rui Li, Guozheng Liang, ShengPeng Wang, András Iring, Johannes Graumann, Nina Wettschureck, Stefan Offermanns

J Clin Invest. 2021 Nov 1; 131(21): e145734. Published online 2021 Nov 1. doi: 10.1172/JCI145734

PMCID:: PMC8553558

Abstract Article PDF–7.7M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74159917.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 70542678.

Novel roles of PRK1 and PRK2 in cilia and cancer biology

Hitesh Patel, Jun Li, Ana Herrero, Jakob Kroboth, Adam Byron, Alex Von Kriegsheim, Valerie Brunton, Neil Carragher, Toby Hurd, Margaret Frame

Sci Rep. 2020; 10: 3902. Published online 2020 Mar 3. doi: 10.1038/s41598-020-60604-3

PMCID:: PMC7054267

Abstract Article PDF–3.2M

Select item 56693649.

The Protein Kinase C Super-family Member PKN is Regulated by mTOR and Influences Differentiation During Prostate Cancer Progression

Chun-Song Yang, Tiffany A. Melhuish, Adam Spencer, Li Ni, Yi Hao, Kasey Jividen, Thurl Harris, Chelsi Snow, Henry Frierson, David Wotton, Bryce M. Paschal

Prostate. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Prostate. 2017 Nov; 77(15): 1452–1467. Published online 2017 Sep 6. doi: 10.1002/pros.23400

PMCID:: PMC5669364

Abstract Article PDF–1.7M

Select item 566859410.

Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle

Maxwell A. Ruby, Isabelle Riedl, Julie Massart, Marcus Åhlin, Juleen R. Zierath

Am J Physiol Endocrinol Metab. 2017 Oct 1; 313(4): E483–E491. Published online 2017 Jul 18. doi: 10.1152/ajpendo.00147.2017

PMCID:: PMC5668594

Abstract Article

Select item 550974011.

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

Brent Wilkinson, Jing Li, Marcelo P. Coba

Sci Rep. 2017; 7: 5272. Published online 2017 Jul 13. doi: 10.1038/s41598-017-05588-3

PMCID:: PMC5509740

Abstract Article PDF–4.6M

Select item 513396812.

PKN2 and Cdo interact to activate AKT and promote myoblast differentiation

Sang-Jin Lee, Jeongmi Hwang, Hyeon-Ju Jeong, Miran Yoo, Ga-Yeon Go, Jae-Rin Lee, Young-Eun Leem, Jong Woo Park, Dong-Wan Seo, Yong Kee Kim, Myong-Joon Hahn, Jeung-Whan Han, Jong-Sun Kang, Gyu-Un Bae

Cell Death Dis. 2016 Oct; 7(10): e2431. Published online 2016 Oct 20. doi: 10.1038/cddis.2016.296

PMCID:: PMC5133968

Abstract Article PDF–3.9M

Select item 502538613.

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

Lawton K. Chung, Yong Hwan Park, Yueting Zheng, Igor E. Brodsky, Patrick Hearing, Daniel L. Kastner, Jae Jin Chae, James B. Bliska

Cell Host Microbe. Author manuscript; available in PMC 2017 Sep 14.

Published in final edited form as: Cell Host Microbe. 2016 Sep 14; 20(3): 296–306. Published online 2016 Aug 25. doi: 10.1016/j.chom.2016.07.018

PMCID:: PMC5025386

Abstract Article PDF–1.1M

Select item 476550314.

DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly

Rieko Ajima, Joseph A Bisson, Jay-Christian Helt, Masa-Aki Nakaya, Raymond Habas, Lino Tessarollo, Xi He, Edward E Morrisey, Terry P. Yamaguchi, Ethan David Cohen

Dev Biol. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Dev Biol. 2015 Dec 1; 408(1): 126–139. Published online 2015 Oct 23. doi: 10.1016/j.ydbio.2015.10.003

PMCID:: PMC4765503

Abstract Article PDF–4.4M

Select item 473308715.

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron

Cell Rep. 2016 Jan 26; 14(3): 440–448. Published online 2016 Jan 7. doi: 10.1016/j.celrep.2015.12.049

PMCID:: PMC4733087

Abstract Article PDF–3.2M

Select item 435840316.

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt

Jernej Murn, Kathi Zarnack, Yawei J. Yang, Omer Durak, Elisabeth A. Murphy, Sihem Cheloufi, Dilenny M. Gonzalez, Marianna Teplova, Tomaž Curk, Johannes Zuber, Dinshaw J. Patel, Jernej Ule, Nicholas M. Luscombe, Li-Huei Tsai, Christopher A. Walsh, Yang Shi

Genes Dev. 2015 Mar 1; 29(5): 501–512. doi: 10.1101/gad.258483.115

PMCID:: PMC4358403

Abstract Article PDF–1.4M

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 352903318.

Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation

Teruhito Yasui, Kaori Sakakibara-Yada, Taki Nishimura, Kentaro Morita, Satoru Tada, George Mosialos, Elliott Kieff, Hitoshi Kikutani

Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51): 21022–21027. Published online 2012 Dec 5. doi: 10.1073/pnas.1218925110

PMCID:: PMC3529033

Abstract Article PDF–1.1M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253420.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

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