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Select item 107843981.

Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo

Marina Paul, Anna Paredes Barreda, Amy Gregson, Richard Kahl, Madeline King, Waleed M. Hussein, Frederick R. Walker, Roger Smith, Tamas Zakar, Jonathan W. Paul

Reprod Sci. 2024 Jan; 31(1): 150–161. Published online 2023 Aug 30. doi: 10.1007/s43032-023-01333-6

PMCID:: PMC10784398

Abstract Article PDF–3.6M

Select item 103541702.

20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index

Marina Paul, Tamas Zakar, Jason Phung, Amy Gregson, Anna Paredes Barreda, Trent A. Butler, Frederick R. Walker, Craig Pennell, Roger Smith, Jonathan W. Paul

Reprod Sci. 2023 Aug; 30(8): 2512–2523. Published online 2023 Feb 10. doi: 10.1007/s43032-023-01183-2

PMCID:: PMC10354170

Abstract Article PDF–2.7M

Select item 97725583.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 94637174.

AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye

Xin Zuo, Hao Zeng, Bowen Wang, Xue Yang, Dalian He, Li Wang, Hong Ouyang, Jin Yuan

Invest Ophthalmol Vis Sci. 2022 Sep; 63(10): 3. Published online 2022 Sep 6. doi: 10.1167/iovs.63.10.3

PMCID:: PMC9463717

Abstract Article PDF–4.5M

Select item 93383135.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 91027266.

VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway

Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan

J Transl Med. 2022; 20: 212. Published online 2022 May 13. doi: 10.1186/s12967-022-03416-5

PMCID:: PMC9102726

Abstract Article PDF–15M

Select item 86236277.

Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death

Nang Lae Lae Phoo, Pornngarm Dejkriengkraikul, Patompong Khaw-On, Supachai Yodkeeree

Int J Mol Sci. 2021 Nov; 22(22): 12512. Published online 2021 Nov 19. doi: 10.3390/ijms222212512

PMCID:: PMC8623627

Abstract Article PDF–6.5M

Select item 82619718.

Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor

Xuenan Liu, Xiaomin Lian, Xuejiao Liu, Yangge Du, Yuan Zhu, Menglong Hu, Ping Zhang, Yunsong Liu, Yongsheng Zhou

Stem Cell Res Ther. 2021; 12: 383. Published online 2021 Jul 7. doi: 10.1186/s13287-021-02425-3

PMCID:: PMC8261971

Abstract Article PDF–2.7M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 752370610.

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis

Katrin Tiemann, Carolina Garri, Sang Bok Lee, Paymaneh D. Malihi, Mincheol Park, Ruth M. Alvarez, Li Peng Yap, Parag Mallick, Jonathan E. Katz, Mitchell E. Gross, Kian Kani

Oncogene. Author manuscript; available in PMC 2020 Sep 29.

Published in final edited form as: Oncogene. 2019 Apr; 38(16): 3003–3018. Published online 2018 Dec 21. doi: 10.1038/s41388-018-0638-9

PMCID:: PMC7523706

Abstract Article PDF–2.3M

Select item 750335511.

Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema

Sandro Michelini, Pietro Chiurazzi, Valerio Marino, Daniele Dell’Orco, Elena Manara, Mirko Baglivo, Alessandro Fiorentino, Paolo Enrico Maltese, Michele Pinelli, Karen Louise Herbst, Astrit Dautaj, Matteo Bertelli

Int J Mol Sci. 2020 Sep; 21(17): 6264. Published online 2020 Aug 29. doi: 10.3390/ijms21176264

PMCID:: PMC7503355

Abstract Article PDF–1.4M

Select item 730600512.

Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer

Shaokun Shu, Hua-Jun Wu, Jennifer Y. Ge, Rhamy Zeid, Isaac S. Harris, Bojana Jovanović, Katherine Murphy, Binbin Wang, Xintao Qiu, Jennifer E. Endress, Jaime Reyes, Klothilda Lim, Alba Font-Tello, Sudeepa Syamala, Tengfei Xiao, Chandra Sekhar Reddy Chilamakuri, Evangelia K. Papachristou, Clive D’Santos, Jayati Anand, Kunihiko Hinohara, Wei Li, Thomas O. McDonald, Adrienne Luoma, Rebecca J. Modiste, Quang-De Nguyen, Brittany Michel, Paloma Cejas, Cigall Kadoch, Jacob D. Jaffe, Kai W. Wucherpfennig, Jun Qi, X. Shirley Liu, Henry Long, Myles Brown, Jason S. Carroll, Joan S. Brugge, James Bradner, Franziska Michor, Kornelia Polyak

Mol Cell. Author manuscript; available in PMC 2021 Jun 18.

Published in final edited form as: Mol Cell. 2020 Jun 18; 78(6): 1096–1113.e8. Published online 2020 May 15. doi: 10.1016/j.molcel.2020.04.027

PMCID:: PMC7306005

Abstract Article PDF–3.2M

Select item 729412713.

Loss of AKR1C1 is a good prognostic factor in advanced NPC cases and increases chemosensitivity to cisplatin in NPC cells

Chen Zhou, Guowen Shen, Fan Yang, Jingling Duan, Zhen Wu, Mingqing Yang, Yi Liu, Xueli Du, Xiaoling Zhang, Shengjun Xiao

J Cell Mol Med. 2020 Jun; 24(11): 6438–6447. Published online 2020 Apr 19. doi: 10.1111/jcmm.15291

PMCID:: PMC7294127

Abstract Article PDF–1.8M

Select item 716998314.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 701915815.

The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer

Hong Zhu, Yan Hu, Chenming Zeng, Linlin Chang, Fujin Ge, Weihua Wang, Fangjie Yan, Qinxin Zhao, Ji Cao, Meidan Ying, Yongchuan Gu, Lin Zheng, Qiaojun He, Bo Yang

Theranostics. 2020; 10(5): 2188–2200. Published online 2020 Jan 12. doi: 10.7150/thno.39151

PMCID:: PMC7019158

Abstract Article PDF–2.1M

Select item 688306616.

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

Mara Gagliardi, Diego Cotella, Claudio Santoro, Davide Corà, Nickolai A. Barlev, Mauro Piacentini, Marco Corazzari

Cell Death Dis. 2019 Dec; 10(12): 902. Published online 2019 Nov 28. doi: 10.1038/s41419-019-2143-7

PMCID:: PMC6883066

Abstract Article PDF–1.2M

Select item 661481417.

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA

You Li, Li Wang, Efraín E Rivera-Serrano, Xian Chen, Stanley M Lemon

Nucleic Acids Res. 2019 Jul 9; 47(12): 6411–6424. Published online 2019 Apr 18. doi: 10.1093/nar/gkz278

PMCID:: PMC6614814

Abstract Article PDF–4.9M

Select item 655889818.

AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway

Wei-Min Chang, Yu-Chan Chang, Yi-Chieh Yang, Sze-Kwan Lin, Peter Mu-Hsin Chang, Michael Hsiao

J Exp Clin Cancer Res. 2019; 38: 245. Published online 2019 Jun 10. doi: 10.1186/s13046-019-1256-2

PMCID:: PMC6558898

Abstract Article PDF–4.5M

Select item 577108519.

AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer

Hong ZHU, Lin-Lin CHANG, Fang-Jie YAN, Yan HU, Chen-Ming ZENG, Tian-Yi ZHOU, Tao YUAN, Mei-Dan YING, Ji CAO, Qiao-Jun HE, Bo YANG

Theranostics. 2018; 8(3): 676–692. Published online 2018 Jan 1. doi: 10.7150/thno.21463

PMCID:: PMC5771085

Abstract Article PDF–4.0M

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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