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Select item 112909761.

PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis

Junna Yamaguchi, Pierre Isnard, Noémie Robil, Pierre de la Grange, Clément Hoguin, Alain Schmitt, Aurélie Hummel, Jérôme Megret, Nicolas Goudin, Marine Luka, Mickaël M. Ménager, Cécile Masson, Mohammed Zarhrate, Christine Bôle-Feysot, Michalina Janiszewska, Kornelia Polyak, Julien Dairou, Sara Baldassari, Stéphanie Baulac, Christine Broissand, Christophe Legendre, Fabiola Terzi, Guillaume Canaud

J Clin Invest. 2024 Aug 1; 134(15): e176402. Published online 2024 Jun 6. doi: 10.1172/JCI176402

PMCID:: PMC11290976

Abstract Article PDF–32M

Select item 111723302.

Genetic Insights into Colorectal Cancer: Evaluating PI3K/AKT Signaling Pathway Genes Expression

Rafał Świechowski, Jacek Pietrzak, Agnieszka Wosiak, Michał Mik, Ewa Balcerczak

Int J Mol Sci. 2024 Jun; 25(11): 5806. Published online 2024 May 27. doi: 10.3390/ijms25115806

PMCID:: PMC11172330

Abstract Article PDF–5.0M

Select item 111600123.

PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

Ken‐ichi Kozaki, Issei Imoto, Atiphan Pimkhaokham, Shogo Hasegawa, Hitoshi Tsuda, Ken Omura, Johji Inazawa

Cancer Sci. 2006 Dec; 97(12): 1351–1358. Published online 2006 Oct 17. doi: 10.1111/j.1349-7006.2006.00343.x

PMCID:: PMC11160012

Abstract Article PDF–199K

Select item 111587264.

Concomitant activation of AKT with extracellular‐regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss

Noriko Mori, Satoru Kyo, Junko Sakaguchi, Yasunari Mizumoto, Satoshi Ohno, Yoshiko Maida, Manabu Hashimoto, Masahiro Takakura, Masaki Inoue

Cancer Sci. 2007 Dec; 98(12): 1881–1888. Published online 2007 Oct 9. doi: 10.1111/j.1349-7006.2007.00630.x

PMCID:: PMC11158726

Abstract Article PDF–2.2M

Select item 111583905.

PIK3CA amplification is predictive of poor prognosis in Tunisian patients with nasopharyngeal carcinoma

Ali Fendri, Abdelmajid Khabir, Wafa Mnejja, Tahia Sellami‐Boudawara, Jamel Daoud, Mounir Frikha, Abdelmonem Ghorbel, Ali Gargouri, Raja Mokdad‐Gargouri

Cancer Sci. 2009 Nov; 100(11): 2034–2039. Published online 2009 Jul 21. doi: 10.1111/j.1349-7006.2009.01292.x

PMCID:: PMC11158390

Abstract Article PDF–427K

Select item 111432146.

PIK3CA mutations in endocrine-resistant breast cancer

Caroline Schagerholm, Stephanie Robertson, Hosein Toosi, Emmanouil G. Sifakis, Johan Hartman

Sci Rep. 2024; 14: 12542. Published online 2024 May 31. doi: 10.1038/s41598-024-62664-1

PMCID:: PMC11143214

Abstract Article PDF–2.4M

Select item 111134387.

PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner

Oscar Lindblad, Julhash U. Kazi, Lars Rönnstrand, Jianmin Sun

Cell Mol Life Sci. 2015 Nov; 72(22): 4399–4407. Published online 2015 Jun 4. doi: 10.1007/s00018-015-1944-9

PMCID:: PMC11113438

Abstract Article PDF–997K

Select item 110726768.

Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth

Yen-Sung Huang, Chang-Chieh Wu, Che-Chang Chang, Shiu-Feng Huang, Hong-Yi Kuo, Hsiu-Ming Shih

Cell Mol Life Sci. 2022 Jul; 79(7): 367. Published online 2022 Jun 19. doi: 10.1007/s00018-022-04399-8

PMCID:: PMC11072676

Abstract Article PDF–8.2M

Select item 109278169.

PIK3CA mutation-driven immune signature as a prognostic marker for evaluating the tumor immune microenvironment and therapeutic response in breast cancer

Xueting Ren, Hanxiao Cui, Luyao Dai, Lidan Chang, Dandan Liu, Wenyu Yan, Xuyan Zhao, Huafeng Kang, Xiaobin Ma

J Cancer Res Clin Oncol. 2024; 150(3): 119. Published online 2024 Mar 11. doi: 10.1007/s00432-024-05626-4

PMCID:: PMC10927816

Abstract Article PDF–2.9M

Select item 1085094410.

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

Andreas Varkaris, Ferran Fece de la Cruz, Elizabeth E. Martin, Bryanna L. Norden, Nicholas Chevalier, Allison M. Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S. Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P. Danysh, Laxmi Parida, Ioannis Sanidas, Yongli Ji, Kayao Lau, Gerburg M. Wulf, Aditya Bardia, Laura M. Spring, Steven J. Isakoff, Jochen K. Lennerz, Kathryn Del Vecchio, Levi Pierce, Ermira Pazolli, Gad Getz, Ryan B. Corcoran, Dejan Juric

Cancer Discov. 2024 Feb 8; 14(2): 227–239. Published online 2023 Oct 31. doi: 10.1158/2159-8290.CD-23-0704

PMCID:: PMC10850944

Abstract Article PDF–14M

Select item 1082994311.

Microcystic Lymphatic Malformations in Turner Syndrome are due to Somatic Mosaicism of PIK3CA

Bede N. Nriagu, Lydia S. Williams, Niambi Brewer, Lea F. Surrey, Abhay S. Srinivasan, Dong Li, Allison Britt, James Treat, T. Blaine Crowley, Nora O’Connor, Arupa Ganguly, David Low, Maria Queenan, Theodore G. Drivas, Elaine H. Zackai, Denise M. Adams, Hakon Hakonarson, Kristen M. Snyder, Sarah E. Sheppard

Am J Med Genet A. Author manuscript; available in PMC 2024 Jan 31.

Published in final edited form as: Am J Med Genet A. 2024 Jan; 194(1): 64–69. Published online 2023 Sep 13. doi: 10.1002/ajmg.a.63385

PMCID:: PMC10829943

Abstract Article PDF–893K

Select item 1077597812.

PIK3CA regulates development of diabetes retinopathy through the PI3K/Akt/mTOR pathway

Ruijuan Guan, Zefeng Kang, Ling Li, Xin Yan, Tianpeng Gao

PLoS One. 2024; 19(1): e0295813. Published online 2024 Jan 9. doi: 10.1371/journal.pone.0295813

PMCID:: PMC10775978

Abstract Article PDF–1.9M

Select item 1073380713.

Association of PIK3CA Mutation With Pathologic Complete Response and Outcome by Hormone Receptor Status and Intrinsic Subtype in Early-Stage ERBB2/HER2-Positive Breast Cancer

Paola Zagami, Aranzazu Fernandez-Martinez, Naim U. Rashid, Katherine A. Hoadley, Patricia A. Spears, Giuseppe Curigliano, Charles M. Perou, Lisa A. Carey

JAMA Netw Open. 2023 Dec; 6(12): e2348814. Published online 2023 Dec 20. doi: 10.1001/jamanetworkopen.2023.48814

PMCID:: PMC10733807

Abstract Article

Select item 1068449914.

Coexistent ARID1A-PIK3CA mutations are associated with immune-related pathways in luminal breast cancer

Liat Anabel Sinberger, Tamar Zahavi, Amir Sonnenblick, Mali Salmon‐Divon

Sci Rep. 2023; 13: 20911. Published online 2023 Nov 27. doi: 10.1038/s41598-023-48002-x

PMCID:: PMC10684499

Abstract Article PDF–4.2M

Select item 1064675415.

Oncogenic PIK3CA recruits myeloid‐derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5‐lipoxygenase‐dependent arachidonic acid pathway

Xingchen Li, Guidong Chen, Fanchen Wang, Xiaojing Guo, Rui Zhang, Pengpeng Liu, Li Dong, Wenwen Yu, Huan Wang, Hailong Wang, Jinpu Yu

Clin Transl Med. 2023 Nov; 13(11): e1483. Published online 2023 Nov 15. doi: 10.1002/ctm2.1483

PMCID:: PMC10646754

Abstract Article PDF–16M

Select item 1054668516.

Interplay between ESR1/PIK3CA codon variants, oncogenic pathway alterations and clinical phenotype in patients with metastatic breast cancer (MBC): comprehensive circulating tumor DNA (ctDNA) analysis

Lorenzo Gerratana, Andrew A. Davis, Marko Velimirovic, Katherine Clifton, Whitney L. Hensing, Ami N. Shah, Charles S. Dai, Carolina Reduzzi, Paolo D’Amico, Firas Wehbe, Arielle Medford, Seth A. Wander, William J. Gradishar, Amir Behdad, Fabio Puglisi, Cynthia X. Ma, Aditya Bardia, Massimo Cristofanilli

Breast Cancer Res. 2023; 25: 112. Published online 2023 Oct 2. doi: 10.1186/s13058-023-01718-0

PMCID:: PMC10546685

Abstract Article PDF–3.7M

Select item 1052701717.

Breast cancer mutations HER2^V777L and PIK3CA^H1047R activate the p21-CDK4/6 –Cyclin D1 axis driving tumorigenesis and drug resistance

Xiaoqing Cheng, Yirui Sun, Maureen Highkin, Nagalaxmi Vemalapally, Xiaohua Jin, Brandon Zhou, Julie L. Prior, Ashley R. Tipton, Shunqiang Li, Anton Iliuk, Samuel Achilefu, Ian S. Hagemann, John R. Edwards, Ron Bose

Cancer Res. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Cancer Res. 2023 Sep 1; 83(17): 2839–2857. doi: 10.1158/0008-5472.CAN-22-3558

PMCID:: PMC10527017

Abstract Article PDF–4.7M

Select item 1050343018.

Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition

Charles Bayard, Eleonora Segna, Maxime Taverne, Antoine Fraissenon, Quentin Hennocq, Baptiste Periou, Lola Zerbib, Sophia Ladraa, Célia Chapelle, Clément Hoguin, Sophie Kaltenbach, Patrick Villarese, Vahid Asnafi, Christine Broissand, Ivan Nemazanyy, Gwennhael Autret, Nicolas Goudin, Christophe Legendre, François-Jérôme Authier, Thomas Viel, Bertrand Tavitian, Cyril Gitiaux, Sylvie Fraitag, Jean-Paul Duong, Clarisse Delcros, Bernard Sergent, Arnaud Picard, Michael Dussiot, Laurent Guibaud, Roman Khonsari, Guillaume Canaud

J Exp Med. 2023 Nov 6; 220(11): e20230926. Published online 2023 Sep 15. doi: 10.1084/jem.20230926

PMCID:: PMC10503430

Abstract Article PDF–6.4M

Select item 1049606619.

Wataru Arihisa, Takeshi Kondo, Katsushi Yamaguchi, Junya Matsumoto, Hiroki Nakanishi, Yasuto Kunii, Hiroyasu Akatsu, Mizuki Hino, Yoshio Hashizume, Shumpei Sato, Shinji Sato, Shin‐Ichi Niwa, Hirooki Yabe, Takehiko Sasaki, Shuji Shigenobu, Mitsutoshi Setou

Neuropsychopharmacol Rep. 2023 Sep; 43(3): 403–413. Published online 2023 Jul 27. doi: 10.1002/npr2.12368

PMCID:: PMC10496066

Abstract Article PDF–1.2M

Select item 1047475120.

Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations

Bin Zhang, Rui He, Zigang Xu, Yujuan Sun, Li Wei, Li Li, Yuanxiang Liu, Wu Guo, Li Song, Huijun Wang, Zhimiao Lin, Lin Ma

Orphanet J Rare Dis. 2023; 18: 261. Published online 2023 Sep 1. doi: 10.1186/s13023-023-02860-w

PMCID:: PMC10474751

Abstract Article PDF–1.7M

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PMC Links for GEO Profiles (Select 131941017) (850)
PMC
dbVar for Gene (Select 5290) (419)
dbVar
PREDICTED: Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic...
PREDICTED: Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), transcript variant X2, mRNA
gi|2462590470|ref|XM_054346843.1|

Nucleotide
RecName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit a...
RecName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Short=PI3-kinase subunit alpha; Short=PI3K-alpha; Short=PI3Kalpha; Short=PtdIns-3-kinase subunit alpha; AltName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Short=PtdIns-3-kinase subunit p110-alpha; Short=p110alpha; AltName: Full=Phosphoinositide 3-kinase alpha; AltName: Full=Phosphoinositide-3-kinase catalytic alpha polypeptide; AltName: Full=Serine/threonine protein kinase PIK3CA
gi|126302584|sp|P42336.2|PK3CA_HUMA

Protein

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