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Select item 86993221.

RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth

Takuya Kano, Ryosuke Tsumagari, Akio Nakashima, Ushio Kikkawa, Shuji Ueda, Minoru Yamanoue, Nobuyuki Takei, Yasuhito Shirai

Biomolecules. 2021 Dec; 11(12): 1814. Published online 2021 Dec 2. doi: 10.3390/biom11121814

PMCID:: PMC8699322

Abstract Article PDF–1.3M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 55316113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 47053924.

Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion

Kristen Fite, Julian Gomez-Cambronero

J Biol Chem. 2016 Jan 8; 291(2): 719–730. Published online 2015 Nov 15. doi: 10.1074/jbc.M115.686006

PMCID:: PMC4705392

Abstract Article PDF–3.1M

Select item 46866935.

The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5

Mi Hee Park, Kang-Yell Choi, Do Sik Min

Exp Mol Med. 2015 Dec; 47(12): e200. Published online 2015 Dec 18. doi: 10.1038/emm.2015.101

PMCID:: PMC4686693

Abstract Article PDF–1.4M

Select item 43950936.

Phosphatidylinositol-Glycan-Phospholipase D Is Involved in Neurodegeneration in Prion Disease

Jae-Kwang Jin, Byungki Jang, Hyoung Tae Jin, Eun-Kyoung Choi, Cha-Gyun Jung, Hiroyasu Akatsu, Jae-Il Kim, Richard I. Carp, Yong-Sun Kim

PLoS One. 2015; 10(4): e0122120. Published online 2015 Apr 13. doi: 10.1371/journal.pone.0122120

PMCID:: PMC4395093

Abstract Article PDF–499K

Select item 43581227.

Reciprocal Regulation of AMP-activated Protein Kinase and Phospholipase D

Suman Mukhopadhyay, Mahesh Saqcena, Amrita Chatterjee, Avalon Garcia, Maria A. Frias, David A. Foster

J Biol Chem. 2015 Mar 13; 290(11): 6986–6993. Published online 2015 Jan 29. doi: 10.1074/jbc.M114.622571

PMCID:: PMC4358122

Abstract Article PDF–1.3M

Select item 41327668.

Phospholipase D and the Maintenance of Phosphatidic Acid Levels for Regulation of Mammalian Target of Rapamycin (mTOR)

David A. Foster, Darin Salloum, Deepak Menon, Maria A. Frias

J Biol Chem. 2014 Aug 15; 289(33): 22583–22588. Published online 2014 Jul 2. doi: 10.1074/jbc.R114.566091

PMCID:: PMC4132766

Abstract Article PDF–638K

Select item 41327659.

Functional Regulation of Phospholipase D Expression in Cancer and Inflammation

Dong Woo Kang, Kang-Yell Choi, Do Sik Min

J Biol Chem. 2014 Aug 15; 289(33): 22575–22582. Published online 2014 Jul 2. doi: 10.1074/jbc.R114.569822

PMCID:: PMC4132765

Abstract Article PDF–674K

Select item 413276210.

Thematic Minireview Series on Phospholipase D and Cancer

Julian Gomez-Cambronero, George M. Carman

J Biol Chem. 2014 Aug 15; 289(33): 22554–22556. Published online 2014 Jul 2. doi: 10.1074/jbc.R114.593137

PMCID:: PMC4132762

Abstract Article PDF–86K

Select item 385716311.

Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low fat but not a low carbohydrate diet in obese women

Dona L. Gray, Kevin D. O’Brien, David A. D’Alessio, Bonnie J. Brehm, Mark A. Deeg

Metabolism. Author manuscript; available in PMC 2013 Dec 9.

Published in final edited form as: Metabolism. 2008 Apr; 57(4): 10.1016/j.metabol.2007.11.007. doi: 10.1016/j.metabol.2007.11.007

PMCID:: PMC3857163

Abstract Article PDF–198K

Select item 377350512.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

Simona Principe, E. Ellen Jones, Yunee Kim, Ankit Sinha, Julius O. Nyalwidhe, Jasmin Brooks, O. John Semmes, Dean A. Troyer, Raymond S. Lance, Thomas Kislinger, Richard R. Drake

Proteomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Proteomics. 2013 May; 13(0): 1667–1671. Published online 2013 Apr 23. doi: 10.1002/pmic.201200561

PMCID:: PMC3773505

Abstract Article PDF–630K

Select item 361866713.

Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras

Ming Shi, Yang Zheng, Avalon Garcia, Lizhong Xu, David A. Foster

Cancer Lett. Author manuscript; available in PMC 2013 Apr 6.

Published in final edited form as: Cancer Lett. 2007 Dec 18; 258(2): 268–275. Published online 2007 Oct 18. doi: 10.1016/j.canlet.2007.09.003

PMCID:: PMC3618667

Abstract Article PDF–1.1M

Select item 350314714.

Pulmonary Fibrosis Inducer, Bleomycin, Causes Redox-Sensitive Activation of Phospholipase D and Cytotoxicity Through Formation of Bioactive Lipid Signal Mediator, Phosphatidic Acid, in Lung Microvascular Endothelial Cells

Rishi B. Patel, Sainath R. Kotha, Shariq I. Sherwani, Sean M. Sliman, Travis O. Gurney, Brooke Loar, Susan O’Connor Butler, Andrew J. Morris, Clay B. Marsh, Narasimham L. Parinandi

Int J Toxicol. Author manuscript; available in PMC 2012 Nov 21.

Published in final edited form as: Int J Toxicol. 2011 Feb; 30(1): 69–90. Published online 2010 Dec 3. doi: 10.1177/1091581810388850

PMCID:: PMC3503147

Abstract Article PDF–3.2M

Select item 348237215.

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

John C Chambers, Weihua Zhang, Joban Sehmi, Xinzhong Li, Mark N Wass, Pim Van der Harst, Hilma Holm, Serena Sanna, Maryam Kavousi, Sebastian E Baumeister, Lachlan J Coin, Guohong Deng, Christian Gieger, Nancy L Heard-Costa, Jouke-Jan Hottenga, Brigitte Kühnel, Vinod Kumar, Vasiliki Lagou, Liming Liang, Jian’an Luan, Pedro Marques Vidal, Irene Mateo Leach, Paul F O’Reilly, John F Peden, Nilufer Rahmioglu, Pasi Soininen, Elizabeth K Speliotes, Xin Yuan, Gudmar Thorleifsson, Behrooz Z Alizadeh, Larry D Atwood, Ingrid B Borecki, Morris J Brown, Pimphen Charoen, Francesco Cucca, Debashish Das, Eco J C de Geus, Anna L Dixon, Angela Döring, Georg Ehret, Gudmundur I Eyjolfsson, Martin Farrall, Nita G Forouhi, Nele Friedrich, Wolfram Goessling, Daniel F Gudbjartsson, Tamara B Harris, Anna-Liisa Hartikainen, Simon Heath, Gideon M Hirschfield, Albert Hofman, Georg Homuth, Elina Hyppönen, Harry L A Janssen, Toby Johnson, Antti J Kangas, Ido P Kema, Jens P Kühn, Sandra Lai, Mark Lathrop, Markus M Lerch, Yun Li, T Jake Liang, Jing-Ping Lin, Ruth J F Loos, Nicholas G Martin, Miriam F Moffatt, Grant W Montgomery, Patricia B Munroe, Kiran Musunuru, Yusuke Nakamura, Christopher J O’Donnell, Isleifur Olafsson, Brenda W Penninx, Anneli Pouta, Bram P Prins, Inga Prokopenko, Ralf Puls, Aimo Ruokonen, Markku J Savolainen, David Schlessinger, Jeoffrey N L Schouten, Udo Seedorf, Srijita Sen-Chowdhry, Katherine A Siminovitch, Johannes H Smit, Timothy D Spector, Wenting Tan, Tanya M Teslovich, Taru Tukiainen, Andre G Uitterlinden, Melanie M Van der Klauw, Ramachandran S Vasan, Chris Wallace, Henri Wallaschofski, H-Erich Wichmann, Gonneke Willemsen, Peter Würtz, Chun Xu, Laura M Yerges-Armstrong, Alcohol Genome-wide Association (AlcGen) Consortium, Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study, Genetic Investigation of Anthropometric Traits (GIANT) Consortium, Global Lipids Genetics Consortium, Genetics of Liver Disease (GOLD) Consortium, International Consortium for Blood Pressure (ICBP-GWAS), Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Goncalo R Abecasis, Kourosh R Ahmadi, Dorret I Boomsma, Mark Caulfield, William O Cookson, Cornelia M van Duijn, Philippe Froguel, Koichi Matsuda, Mark I McCarthy, Christa Meisinger, Vincent Mooser, Kirsi H Pietiläinen, Gunter Schumann, Harold Snieder, Michael J E Sternberg, Ronald P Stolk, Howard C Thomas, Unnur Thorsteinsdottir, Manuela Uda, Gérard Waeber, Nicholas J Wareham, Dawn M Waterworth, Hugh Watkins, John B Whitfield, Jacqueline C M Witteman, Bruce H R Wolffenbuttel, Caroline S Fox, Mika Ala-Korpela, Kari Stefansson, Peter Vollenweider, Henry Völzke, Eric E Schadt, James Scott, Marjo-Riitta Järvelin, Paul Elliott, Jaspal S Kooner

Nat Genet. Author manuscript; available in PMC 2012 Oct 27.

Published in final edited form as: Nat Genet. 2011 Oct 16; 43(11): 1131–1138. Published online 2011 Oct 16. doi: 10.1038/ng.970

PMCID:: PMC3482372

Abstract Article PDF–1.7M

Select item 339791916.

Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells

Jelena Pribic, Derrick Brazill

Cell Signal. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: Cell Signal. 2012 Aug; 24(8): 1531–1540. Published online 2012 Mar 28. doi: 10.1016/j.cellsig.2012.03.015

PMCID:: PMC3397919

Abstract Article PDF–6.0M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 307030018.

PNPLA3 Variants Specifically Confer Increased Risk for Histologic Nonalcoholic Fatty Liver Disease But Not Metabolic Disease

Elizabeth K. Speliotes, Johannah L. Butler, Cameron D. Palmer, Benjamin F. Voight, the GIANT Consortium, the MIGen Consortium, the NASH CRN, Joel N. Hirschhorn

Hepatology. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Hepatology. 2010 Sep; 52(3): 904–912. doi: 10.1002/hep.23768

PMCID:: PMC3070300

Abstract Article PDF–342K

Select item 274057219.

A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication

Man Lung Yeung, Laurent Houzet, Venkat S. R. K. Yedavalli, Kuan-Teh Jeang

J Biol Chem. 2009 Jul 17; 284(29): 19463–19473. Published online 2009 May 20. doi: 10.1074/jbc.M109.010033

PMCID:: PMC2740572

Abstract Article PDF–2.5M

Select item 256193720.

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

Xin Yuan, Dawn Waterworth, John R.B. Perry, Noha Lim, Kijoung Song, John C. Chambers, Weihua Zhang, Peter Vollenweider, Heide Stirnadel, Toby Johnson, Sven Bergmann, Noam D. Beckmann, Yun Li, Luigi Ferrucci, David Melzer, Dena Hernandez, Andrew Singleton, James Scott, Paul Elliott, Gerard Waeber, Lon Cardon, Timothy M. Frayling, Jaspal S. Kooner, Vincent Mooser

Am J Hum Genet. 2008 Oct 10; 83(4): 520–528. Published online 2008 Oct 3. doi: 10.1016/j.ajhg.2008.09.012

PMCID:: PMC2561937

Abstract Article PDF–572K

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