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Select item 91197361.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 88421652.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 85529073.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74409195.

Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

Marina Schrecker, Julia Korobenko, Richard K Hite

eLife. 2020; 9: e59555. Published online 2020 Aug 4. doi: 10.7554/eLife.59555

PMCID:: PMC7440919

Abstract Article PDF–9.0M

Select item 74233706.

Molecular insights into the human CLC-7/Ostm1 transporter

Sensen Zhang, Yang Liu, Bing Zhang, Jun Zhou, Tianyu Li, Zhiqiang Liu, Yang Li, Maojun Yang

Sci Adv. 2020 Aug; 6(33): eabb4747. Published online 2020 Aug 12. doi: 10.1126/sciadv.abb4747

PMCID:: PMC7423370

Abstract Article PDF–3.0M

Select item 73220677.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 72694418.

Osteopetrosis-Associated Transmembrane Protein 1 Recruits RNA Exosome To Restrict Hepatitis B Virus Replication

Chunqiang Ma, Wei Xu, Qingyu Yang, Weiyong Liu, Qi Xiang, Junbo Chen, Qi Zhang, Yingle Liu, Kailang Wu, Jianguo Wu

J Virol. 2020 Jun; 94(11): e01800-19. Prepublished online 2020 Mar 18. Published online 2020 May 18. doi: 10.1128/JVI.01800-19

PMCID:: PMC7269441

Abstract Article PDF–4.7M

Select item 55581799.

Coexisting variants in OSTM1 and MANEAL cause a complex neurodegenerative disorder with NBIA-like brain abnormalities

Diran Herebian, Bader Alhaddad, Annette Seibt, Thomas Schwarzmayr, Katharina Danhauser, Dirk Klee, Stefani Harmsen, Thomas Meitinger, Tim M Strom, Ansgar Schulz, Ertan Mayatepek, Tobias B Haack, Felix Distelmaier

Eur J Hum Genet. 2017 Sep; 25(9): 1092–1095. Published online 2017 Jun 14. doi: 10.1038/ejhg.2017.96

PMCID:: PMC5558179

Abstract Article PDF–1.1M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 471942811.

Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking

Subramanya N. M. Pandruvada, Janie Beauregard, Suzanne Benjannet, Monica Pata, Claude Lazure, Nabil G. Seidah, Jean Vacher

Mol Cell Biol. 2016 Feb 1; 36(3): 507–521. Prepublished online 2015 Nov 23. Published online 2016 Jan 19. doi: 10.1128/MCB.00656-15

PMCID:: PMC4719428

Abstract Article PDF–4.0M

Select item 461721112.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 427685613.

Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis

Bongjin Shin, Jungeun Yu, Eui-Soon Park, Seunga Choi, Jiyeon Yu, Jung Me Hwang, Hyeongseok Yun, Young-Ho Chung, Kwan Soo Hong, Jong-Soon Choi, Masamichi Takami, Jaerang Rho

J Biol Chem. 2014 Dec 26; 289(52): 35868–35881. Published online 2014 Oct 30. doi: 10.1074/jbc.M114.589614

PMCID:: PMC4276856

Abstract Article PDF–3.7M

Select item 427511714.

OSTM1 Regulates β-catenin/Lef1 Interaction and is Required for Wnt/β-catenin Signaling

Michael E. Feigin, Craig C. Malbon

Cell Signal. Author manuscript; available in PMC 2014 Dec 23.

Published in final edited form as: Cell Signal. 2008 May; 20(5): 949–957. Published online 2008 Jan 24. doi: 10.1016/j.cellsig.2008.01.009

PMCID:: PMC4275117

Abstract Article PDF–4.5M

Select item 406471815.

Charting the Landscape of Tandem BRCT Domain-Mediated Protein Interactions

Nicholas T. Woods, Rafael D. Mesquita, Michael Sweet, Marcelo A. Carvalho, Xueli Li, Yun Liu, Huey Nguyen, C. Eric Thomas, Edwin S. Iversen, Jr., Sylvia Marsillac, Rachel Karchin, John Koomen, Alvaro N.A. Monteiro

Sci Signal. Author manuscript; available in PMC 2014 Jun 20.

Published in final edited form as: Sci Signal. 2012; 5(242): rs6. Published online 2012 Sep 18. doi: 10.1126/scisignal.2002255

PMCID:: PMC4064718

Abstract Article PDF–2.1M

Select item 402286316.

Severe Neurodegeneration with Impaired Autophagy Mechanism Triggered by Ostm1 Deficiency

Céline Héraud, Adam Griffiths, Subramanya N. M. Pandruvada, Manfred W. Kilimann, Monica Pata, Jean Vacher

J Biol Chem. 2014 May 16; 289(20): 13912–13925. Published online 2014 Apr 9. doi: 10.1074/jbc.M113.537233

PMCID:: PMC4022863

Abstract Article PDF–3.4M

Select item 378996017.

Common Gating of Both CLC Transporter Subunits Underlies Voltage-dependent Activation of the 2Cl⁻/1H⁺ Exchanger ClC-7/Ostm1

Carmen F. Ludwig, Florian Ullrich, Lilia Leisle, Tobias Stauber, Thomas J. Jentsch

J Biol Chem. 2013 Oct 4; 288(40): 28611–28619. Published online 2013 Aug 27. doi: 10.1074/jbc.M113.509364

PMCID:: PMC3789960

Abstract Article PDF–1.2M

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311765219.

ClC-7 is a slowly voltage-gated 2Cl⁻/1H⁺-exchanger and requires Ostm1 for transport activity

Lilia Leisle, Carmen F Ludwig, Florian A Wagner, Thomas J Jentsch, Tobias Stauber

EMBO J. 2011 Jun 1; 30(11): 2140–2152. Published online 2011 Apr 28. doi: 10.1038/emboj.2011.137

PMCID:: PMC3117652

Abstract Article PDF–1.6M

Select item 279151820.

High-Density Association Study of 383 Candidate Genes for Volumetric BMD at the Femoral Neck and Lumbar Spine Among Older Men

Laura M. Yerges, Lambertus Klei, Jane A. Cauley, Kathryn Roeder, Candace M. Kammerer, Susan P. Moffett, Kristine E. Ensrud, Cara S. Nestlerode, Lynn M. Marshall, Andrew R. Hoffman, Cora Lewis, Thomas F. Lang, Elizabeth Barrett-Connor, Robert E. Ferrell, Eric S. Orwoll, Joseph M. Zmuda

J Bone Miner Res. 2009 Dec; 24(12): 2039–2049. Published online 2009 May 18. doi: 10.1359/JBMR.090524

PMCID:: PMC2791518

Abstract Article PDF–759K

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PMC Links for GEO Profiles (Select 131979737) (27)
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Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent c...
Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent carfilzomib
Accession: GDS5826

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Pancreatic islet-like cell clusters derived from T3 embryonic stem cells
Pancreatic islet-like cell clusters derived from T3 embryonic stem cells
Accession: GDS4011

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