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Select item 109045031.

FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA

Juan Wang, Xinyue Zhao, Qizhi Wang, Xiaojing Zheng, Dilihumaer Simayi, Junli Zhao, Peiyan Yang, Qinwen Mao, Haibin Xia

Cell Mol Life Sci. 2024 Dec; 81(1): 107. Published online 2024 Feb 29. doi: 10.1007/s00018-024-05133-2

PMCID:: PMC10904503

Abstract Article PDF–15M

Select item 108237432.

Activated phosphoinositide 3-kinase δ syndrome caused by PIK3CD mutations: expanding the phenotype

Peiwei Zhao, Juan Huang, Huicong Fu, Jiali Xu, Tianhong Li, Xiankai Zhang, Qingjie Meng, Lei Zhang, Li Tan, Wen Zhang, Hebin Chen, Xiaoxia Lu, Yan Ding, Xuelian He

Pediatr Rheumatol Online J. 2024; 22: 24. Published online 2024 Jan 29. doi: 10.1186/s12969-024-00955-7

PMCID:: PMC10823743

Abstract Article PDF–1.3M

Select item 108055013.

KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway

Tao Wang, Shuo Chen, Ziliang Wang, Siyu Li, Xichang Fei, Tong Wang, Mingjun Zhang

J Cell Mol Med. 2024 Jan; 28(1): e18020. Published online 2023 Nov 1. doi: 10.1111/jcmm.18020

PMCID:: PMC10805501

Abstract Article PDF–36M

Select item 104837414.

CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity

Jiasheng Chen, Yuxin Lin, Shukai zheng, Qingshan Chen, Shijie Tang, Xiaoping Zhong

J Transl Med. 2023; 21: 600. Published online 2023 Sep 6. doi: 10.1186/s12967-023-04478-9

PMCID:: PMC10483741

Abstract Article PDF–7.9M

Select item 104482765.

Mechanisms controlling membrane recruitment and activation of the autoinhibited SHIP1 inositol 5-phosphatase

Grace L. Waddell, Emma E. Drew, Henry P. Rupp, Scott D. Hansen

J Biol Chem. 2023 Aug; 299(8): 105022. Published online 2023 Jul 7. doi: 10.1016/j.jbc.2023.105022

PMCID:: PMC10448276

Abstract Article PDF–2.9M

Select item 103725906.

MLL4 Regulates the Progression of Non–Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis

Yang Yang, Rongfang Qiu, Qiaoyou Weng, Ziwei Xu, Jingjing Song, Siyu Zhao, Miaomiao Meng, Dengke Zhang, Chunli Kong, Hailin Wang, Min Xu, Zhongwei Zhao, Jiansong Ji

Cancer Res Treat. 2023 Jul; 55(3): 778–803. Published online 2023 Jan 26. doi: 10.4143/crt.2022.1042

PMCID:: PMC10372590

Abstract Article PDF–4.8M

Select item 101793177.

AQP3-Dependent PI3K/Akt Modulation in Breast Cancer Cells

Monika Mlinarić, Ivan Lučić, Lidija Milković, Inês V. da Silva, Ivana Tartaro Bujak, Vesna Musani, Graça Soveral, Ana Čipak Gašparović

Int J Mol Sci. 2023 May; 24(9): 8133. Published online 2023 May 1. doi: 10.3390/ijms24098133

PMCID:: PMC10179317

Abstract Article PDF–3.6M

Select item 98572358.

NFκB-Mediated Expression of Phosphoinositide 3-Kinase δ Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells

Haote Han, Yanhui Yang, Zhuo Han, Luping Wang, Lijun Dong, Hui Qi, Bing Liu, Jingkui Tian, Bart Vanhaesebroeck, Andrius Kazlauskas, Guoming Zhang, Shaochong Zhang, Hetian Lei

Cells. 2023 Jan; 12(2): 207. Published online 2023 Jan 4. doi: 10.3390/cells12020207

PMCID:: PMC9857235

Abstract Article PDF–3.7M

Select item 92626149.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 858208011.

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8⁺ T cells at the expense of central memory

Jennifer L. Cannons, Alejandro V. Villarino, Senta M. Kapnick, Silvia Preite, Han-Yu Shih, Julio Gomez-Rodriguez, Zenia Kaul, Hirofumi Shibata, Julie M. Reilley, Bonnie Huang, Robin Handon, Ian T. McBain, Selamawit Gossa, Tuoqi Wu, Helen C. Su, Dorian B. McGavern, John J. O’Shea, Peter J. McGuire, Gulbu Uzel, Pamela L. Schwartzberg

Cell Rep. Author manuscript; available in PMC 2021 Nov 11.

Published in final edited form as: Cell Rep. 2021 Oct 12; 37(2): 109804. doi: 10.1016/j.celrep.2021.109804

PMCID:: PMC8582080

Abstract Article PDF–3.2M

Select item 857115612.

The PI3Kδ inhibitor idelalisib impairs the function of human dendritic cells

Christiane Braun, Sebastian Schlaweck, Solveig Nora Daecke, Peter Brossart, Annkristin Heine

Cancer Immunol Immunother. 2021 Dec; 70(12): 3693–3700. Published online 2021 Jun 25. doi: 10.1007/s00262-021-02988-3

PMCID:: PMC8571156

Abstract Article PDF–3.6M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 811385914.

Case Report: Activating PIK3CD Mutation in Patients Presenting With Granulomatosis With Polyangiitis

Meiping Lu, Weizhong Gu, Yuanjian Sheng, Jingjing Wang, Xuefeng Xu

Front Immunol. 2021; 12: 670312. Published online 2021 Apr 28. doi: 10.3389/fimmu.2021.670312

PMCID:: PMC8113859

Abstract Article PDF–1.5M

Select item 810684215.

A somatic mutation in PIK3CD unravels a novel candidate gene for lymphatic malformation

Shengcai Wang, Wei Wang, Xuexi Zhang, Jingang Gui, Jie Zhang, Yongli Guo, Yuanhu Liu, Lin Han, Qiaoyin Liu, Yanzhen Li, Nian Sun, Zhiyong Liu, Jiangnan Du, Jun Tai, Xin Ni

Orphanet J Rare Dis. 2021; 16: 208. Published online 2021 May 8. doi: 10.1186/s13023-021-01782-9

Correction in:: Orphanet J Rare Dis. 2021; 16: 321.

PMCID:: PMC8106842

Abstract Article PDF–2.5M

Select item 783053416.

Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2

Elanora Dovat, Chunhua Song, Tommy Hu, Mohammad Atiqur Rahman, Pavan Kumar Dhanyamraju, Morgann Klink, Daniel Bogush, Mario Soliman, Shriya Kane, Mary McGrath, Yali Ding, Dhimant Desai, Arati Sharma, Chandrika Gowda

Int J Mol Sci. 2021 Jan; 22(2): 819. Published online 2021 Jan 15. doi: 10.3390/ijms22020819

PMCID:: PMC7830534

Abstract Article PDF–3.7M

Select item 782798017.

LncRNA HOTAIRM1, miR-433-5p and PIK3CD function as a ceRNA network to exacerbate the development of PCOS

Hongmin Guo, Ting Li, Xinhui Sun

J Ovarian Res. 2021; 14: 19. Published online 2021 Jan 23. doi: 10.1186/s13048-020-00742-4

PMCID:: PMC7827980

Abstract Article PDF–1.4M

Select item 735448818.

Human Cytomegalovirus Mediates Unique Monocyte-to-Macrophage Differentiation through the PI3K/SHIP1/Akt Signaling Network

Olesea Cojohari, Jamil Mahmud, Aaron M. Altman, Megan A. Peppenelli, Michael J. Miller, Gary C. Chan

Viruses. 2020 Jun; 12(6): 652. Published online 2020 Jun 17. doi: 10.3390/v12060652

PMCID:: PMC7354488

Abstract Article PDF–3.2M

Select item 726001419.

PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression

Teresa Gagliano, Kalpit Shah, Sofia Gargani, Liyan Lao, Mansour Alsaleem, Jianing Chen, Vasileios Ntafis, Penghan Huang, Angeliki Ditsiou, Viviana Vella, Kritika Yadav, Kamila Bienkowska, Giulia Bresciani, Kai Kang, Leping Li, Philip Carter, Graeme Benstead-Hume, Timothy O’Hanlon, Michael Dean, Frances M.G. Pearl, Soo-Chin Lee, Emad A. Rakha, Andrew R. Green, Dimitris L. Kontoyiannis, Erwei Song, Justin Stebbing, Georgios Giamas

J Clin Invest. 2020 Jun 1; 130(6): 3188–3204. Published online 2020 May 11. doi: 10.1172/JCI128313

PMCID:: PMC7260014

Abstract Article PDF–19M

Select item 716998320.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

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