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Select item 99773161.

The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism

Jeffry C. Granados, Vladimir Ermakov, Koustav Maity, David R. Vera, Geoffrey Chang, Sanjay K. Nigam

JCI Insight. 2023 Jan 24; 8(2): e160437. Published online 2023 Jan 24. doi: 10.1172/jci.insight.160437

PMCID:: PMC9977316

Abstract Article PDF–5.9M

Select item 96228712.

Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions

Neema Jamshidi, Sanjay K. Nigam

Sci Rep. 2022; 12: 18308. Published online 2022 Oct 31. doi: 10.1038/s41598-022-21091-w

PMCID:: PMC9622871

Abstract Article PDF–6.0M

Select item 91902333.

Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier

Raymond K. Hau, Robert R. Klein, Stephen H. Wright, Nathan J. Cherrington

Drug Metab Dispos. 2022 Jun; 50(6): 770–780. Published online 2022 Jun. doi: 10.1124/dmd.121.000748

PMCID:: PMC9190233

Abstract Article PDF–2.8M

Select item 89978294.

Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort

Jiří Vávra, Andrea Mančíková, Kateřina Pavelcová, Lenka Hasíková, Jana Bohatá, Blanka Stibůrková

Cells. 2022 Apr; 11(7): 1063. Published online 2022 Mar 22. doi: 10.3390/cells11071063

PMCID:: PMC8997829

Abstract Article PDF–1.6M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78646766.

The Activity of Organic Anion Transporter-3: Role of Dexamethasone

Haoxun Wang, Chenchang Liu, Guofeng You

J Pharmacol Sci. Author manuscript; available in PMC 2021 Feb 5.

Published in final edited form as: J Pharmacol Sci. 2018 Feb; 136(2): 79–85. Published online 2018 Feb 2. doi: 10.1016/j.jphs.2017.12.011

PMCID:: PMC7864676

Abstract Article PDF–1.1M

Select item 78635907.

Ubiquitin-specific Peptidase 8 Regulates the Trafficking and Stability of the Human Organic Anion Transporter 1

Jinghui Zhang, Chenchang Liu, Guofeng You

Biochim Biophys Acta Gen Subj. Author manuscript; available in PMC 2021 Feb 5.

Published in final edited form as: Biochim Biophys Acta Gen Subj. 2020 Dec; 1864(12): 129701. Published online 2020 Aug 17. doi: 10.1016/j.bbagen.2020.129701

PMCID:: PMC7863590

Abstract Article PDF–1.4M

Select item 74859538.

Genetic Diversity in Drug Transporters: Impact in African Populations

Iris Rajman, Laura Knapp, Imad Hanna

Clin Transl Sci. 2020 Sep; 13(5): 848–860. Published online 2020 Mar 31. doi: 10.1111/cts.12769

Correction in:: Clin Transl Sci. 2022 Jan; 15(1): 287.

PMCID:: PMC7485953

Abstract Article PDF–244K

Select item 68546069.

Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1)

Anna M. Euteneuer, Tamina Seeger‐Nukpezah, Hendrik Nolte, Maja Henjakovic

Physiol Rep. 2019 Nov; 7(21): e14229. Published online 2019 Nov 14. doi: 10.14814/phy2.14229

PMCID:: PMC6854606

Abstract Article PDF–1.2M

Select item 598425210.

Population specific resequencing associates the ATP Binding Cassette Subfamily C Member 4 (ABCC4) gene with gout in New Zealand Maori and Pacific men

Callum Tanner, James Boocock, Eli A Stahl, Amanda Dobbyn, Asim K Mandal, Murray Cadzow, Amanda J Phipps-Green, Ruth K Topless, Jennie Harré Hindmarsh, Lisa K Stamp, Nicola Dalbeth, Hyon K Choi, David B Mount, Tony R Merriman

Arthritis Rheumatol. Author manuscript; available in PMC 2018 Jul 1.

Published in final edited form as: Arthritis Rheumatol. 2017 Jul; 69(7): 1461–1469. Published online 2017 May 31. doi: 10.1002/art.40110

PMCID:: PMC5984252

Abstract Article PDF–554K

Select item 596733511.

A novel SNP in the 5’ regulatory region of organic anion transporter 1 is associated with chronic kidney disease

Chiao-Yin Sun, Mai-Szu Wu, Chin-Chan Lee, Shu-Hong Chen, Kang-Chieh Lo, Yau-Hung Chen

Sci Rep. 2018; 8: 8085. Published online 2018 May 24. doi: 10.1038/s41598-018-26460-y

PMCID:: PMC5967335

Abstract Article PDF–1.3M

Select item 563234712.

Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess

Akiko Ohashi, Kaori Mamada, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa

Mol Cell Biochem. 2017; 435(1): 97–108. Published online 2017 May 22. doi: 10.1007/s11010-017-3060-7

PMCID:: PMC5632347

Abstract Article PDF–548K

Select item 553161113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 550645614.

PKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1

Da Xu, Jinghui Zhang, Qiang Zhang, Yunzhou Fan, Chenchang Liu, Guofeng You

Drug Metab Dispos. 2017 Aug; 45(8): 887–895. Published online 2017 Aug. doi: 10.1124/dmd.117.075861

PMCID:: PMC5506456

Abstract Article PDF–1.6M

Select item 524322115.

The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1

Da Xu, Haoxun Wang, Carol Gardner, Zui Pan, Ping L. Zhang, Jinghui Zhang, Guofeng You

Am J Physiol Renal Physiol. 2016 Aug 1; 311(2): F320–F329. Published online 2016 May 25. doi: 10.1152/ajprenal.00153.2016

PMCID:: PMC5243221

Abstract Article

Select item 486731216.

Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1

Da Xu, Haoxun Wang, Qiang Zhang, Guofeng You

Am J Physiol Renal Physiol. 2016 May 1; 310(9): F821–F831. Published online 2016 Jan 28. doi: 10.1152/ajprenal.00522.2015

PMCID:: PMC4867312

Abstract Article

Select item 406732117.

Linkage Disequilibrium Mapping of the Chromosome 6q21–22.31 Bipolar I Disorder Susceptibility Locus

Jinbo Fan, Iuliana Ionita-Laza, Matthew B. McQueen, Bernie Devlin, Shaun Purcell, Stephen V. Faraone, Michael H. Allen, Charles L. Bowden, Joseph R. Calabrese, Mark D. Fossey, Edward S. Friedman, Laszlo Gyulai, Peter Hauser, Terence B. Ketter, Lauren B. Marangell, David J. Miklowitz, Andrew A. Nierenberg, Jayendra K. Patel, Gary S. Sachs, Michael E. Thase, Francine B. Molay, Michael A. Escamilla, Vishwajit L. Nimgaonkar, Pamela Sklar, Nan M. Laird, Jordan W. Smoller

Am J Med Genet B Neuropsychiatr Genet. Author manuscript; available in PMC 2014 Jun 23.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5; 0(1): 29–37. doi: 10.1002/ajmg.b.30942

PMCID:: PMC4067321

Abstract Article PDF–317K

Select item 368482318.

Three Ubiquitination Sites of Organic Anion Transporter-1 Synergistically Mediate Protein Kinase C–Dependent Endocytosis of the Transporter

Shanshan Li, Qiang Zhang, Guofeng You

Mol Pharmacol. 2013 Jul; 84(1): 139–146. Published online 2013 Jul. doi: 10.1124/mol.113.086769

PMCID:: PMC3684823

Abstract Article PDF–1.2M

Select item 319082619.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907