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Select item 110607111.

Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Remington E Schmidt, Brianna M Bembenek, Zoey B Temesgen, Zhiquan Wang, Federico Innocenti, Deborah Stroka, Robert B Diasio, Carlo R Largiadèr, Steven M Offer

eLife. 2024; 13: RP94075. Published online 2024 Apr 30. doi: 10.7554/eLife.94075

PMCID:: PMC11060711

Abstract Article PDF–1.0M

Select item 107867222.

Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity

Romain Larrue, Sandy Fellah, Benjamin Hennart, Naoual Sabaouni, Nihad Boukrout, Cynthia Van der Hauwaert, Clément Delage, Meyling Cheok, Michaël Perrais, Christelle Cauffiez, Delphine Allorge, Nicolas Pottier

Pharmacogenomics J. 2024; 24(1): 1. Published online 2024 Jan 12. doi: 10.1038/s41397-023-00322-x

PMCID:: PMC10786722

Abstract Article PDF–814K

Select item 104878733.

Genetic Variation in miR-27a Is Associated with Fluoropyrimidine-Associated Toxicity in Patients with Dihydropyrimidine Dehydrogenase Variants after Genotype-Guided Dose Reduction

Samantha Medwid, Theodore J. Wigle, Cameron Ross, Richard B. Kim

Int J Mol Sci. 2023 Sep; 24(17): 13284. Published online 2023 Aug 27. doi: 10.3390/ijms241713284

PMCID:: PMC10487873

Abstract Article PDF–613K

Select item 102655964.

Impact of renal impairment on dihydropyrimidine dehydrogenase (DPD) phenotyping

B. Royer, M. Launay, J. Ciccolini, L. Derain, F. Parant, F. Thomas, J. Guitton

ESMO Open. 2023 Jun; 8(3): 101577. Published online 2023 May 31. doi: 10.1016/j.esmoop.2023.101577

PMCID:: PMC10265596

Abstract Article PDF–498K

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101661676.

Allelic Frequency of DPYD Genetic Variants in Patients With Cancer in Spain: The PhotoDPYD Study

Marta Miarons, Alba Manzaneque Gordón, Pau Riera, Fernando Gutiérrez Nicolás, in Collaboration with the RedDPYD Research Group with the Spanish Society of Hospital Pharmacy (SEFH)

Oncologist. 2023 May; 28(5): e304–e308. Published online 2023 Apr 4. doi: 10.1093/oncolo/oyad077

PMCID:: PMC10166167

Abstract Article PDF–2.5M

Select item 101516157.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 101343048.

Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine‐induced toxicity in an Asian population

Masashi Kanai, Takahisa Kawaguchi, Masahito Kotaka, Dai Manaka, Junichi Hasegawa, Akinori Takagane, Yoshinori Munemoto, Takeshi Kato, Tetsuya Eto, Tetsuo Touyama, Takanori Matsui, Katsunori Shinozaki, Shigemi Matsumoto, Tsunekazu Mizushima, Masaki Mori, Junichi Sakamoto, Atsushi Ohtsu, Takayuki Yoshino, Shigetoyo Saji, Fumihiko Matsuda

Cancer Med. 2023 Apr; 12(7): 7808–7814. Published online 2022 Dec 16. doi: 10.1002/cam4.5541

PMCID:: PMC10134304

Abstract Article PDF–196K

Select item 99224689.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 985768510.

DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation

Theodore J. Wigle, Samantha Medwid, Cameron Ross, Ute I. Schwarz, Richard B. Kim

Curr Oncol. 2023 Jan; 30(1): 663–672. Published online 2023 Jan 4. doi: 10.3390/curroncol30010051

PMCID:: PMC9857685

Abstract Article PDF–427K

Select item 981032111.

Pharmacogenetic Study of the Dihydropyridine Dehydrogenase Gene in Jordanian Patients with Colorectal Cancer

Nusaiba A. Almashagbah, Amjad A. Mahasneh, Khaldon G. Bodoor

Asian Pac J Cancer Prev. 2022 Sep; 23(9): 3061–3069. doi: 10.31557/APJCP.2022.23.9.3061

PMCID:: PMC9810321

Abstract Article PDF–773K

Select item 936094612.

Nucleic Acid Metabolizing Enzyme Levels Predict Chemotherapy Effects in Advanced and Recurrent Colorectal Cancer

Mitsuru Watanabe, Kenji Katsumata, Tetsuo Sumi, Tetsuo Ishizaki, Masanobu Enomoto, Masatoshi Shigoka, Takahiro Wada, Hiroshi Kuwabara, Junichi Mazaki, Kenta Kasahara, Tomoya Tago, Ryutaro Udo, Yuichi Nagakawa, Shigeyuki Kawachi, Akihiko Tsuchida

Asian Pac J Cancer Prev. 2022 Mar; 23(3): 1000–1011. doi: 10.31557/APJCP.2022.23.3.1005

PMCID:: PMC9360946

Abstract Article PDF–318K

Select item 927928513.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 888555814.

Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines

P. García-Alfonso, M. Saiz-Rodríguez, R. Mondéjar, J. Salazar, D. Páez, A. M. Borobia, M. J. Safont, I. García-García, R. Colomer, X. García-González, M. J. Herrero, L. A. López-Fernández, F. Abad-Santos

Clin Transl Oncol. 2022; 24(3): 483–494. Published online 2021 Nov 13. doi: 10.1007/s12094-021-02708-4

PMCID:: PMC8885558

Abstract Article PDF–926K

Select item 860517215.

Dihydropyrimidine dehydrogenase (DPYD) gene c.1627A>G A/G and G/G genotypes are risk factors for lymph node metastasis and distant metastasis of colorectal cancer

Juanzi Zeng, Heming Wu, Qingyan Huang, Jiaquan Li, Zhikang Yu, Zhixiong Zhong

J Clin Lab Anal. 2021 Nov; 35(11): e24023. Published online 2021 Oct 6. doi: 10.1002/jcla.24023

PMCID:: PMC8605172

Abstract Article PDF–421K

Select item 838230416.

DPYD Genotyping in Patients Who Have Planned Cancer Treatment With Fluoropyrimidines: A Health Technology Assessment

Ontario Health (Quality)

Ont Health Technol Assess Ser. 2021; 21(14): 1–186. Published online 2021 Aug 12.

PMCID:: PMC8382304

Abstract Article PDF–2.6M

Select item 828373517.

DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer

Hiroyuki Kato, Aya Naiki-Ito, Shugo Suzuki, Shingo Inaguma, Masayuki Komura, Kenju Nakao, Taku Naiki, Kenta Kachi, Akihisa Kato, Yoichi Matsuo, Satoru Takahashi

Carcinogenesis. 2021 Jul; 42(7): 940–950. Published online 2021 Feb 26. doi: 10.1093/carcin/bgab017

PMCID:: PMC8283735

Abstract Article PDF–20M

Select item 783188518.

Case report: severe toxicity in an African–American patient receiving FOLFOX carrying uncommon allelic variants in DPYD

Tristan M Sissung, Lisa Cordes, Cody J Peer, Shruti Gandhy, Jason Redman, Julius Strauss, William D Figg

Pharmacogenomics. 2021 Jan; 22(2): 81–85. Published online 2020 Dec 11. doi: 10.2217/pgs-2020-0120

PMCID:: PMC7831885

Abstract Article PDF–426K

Select item 732206719.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117