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Select item 102007191.

PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers

Zheng Zhong, Sugunavathi Sepramaniam, Xin Hui Chew, Kris Wood, May Ann Lee, Babita Madan, David M. Virshup

Oncogene. Author manuscript; available in PMC 2023 May 22.

Published in final edited form as: Oncogene. 2019 Oct; 38(40): 6662–6677. Published online 2019 Aug 7. doi: 10.1038/s41388-019-0908-1

PMCID:: PMC10200719

Abstract Article PDF–2.6M

Select item 97954142.

Suppression of Wnt/β-catenin signaling is associated with downregulation of Wnt1, PORCN and Rspo2 in Alzheimer’s disease

Jesse R. Macyczko, Na Wang, Jing Zhao, Yingxue Ren, Wenyan Lu, Tadafumi C. Ikezu, Na Zhao, Chia-Chen Liu, Guojun Bu, Yonghe Li

Mol Neurobiol. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Mol Neurobiol. 2023 Jan; 60(1): 26–35. Published online 2022 Oct 10. doi: 10.1007/s12035-022-03065-1

PMCID:: PMC9795414

Abstract Article PDF–1.5M

Select item 94044573.

Mechanisms and Inhibition of Porcupine-Mediated Wnt Acylation

Yang Liu, Xiaofeng Qi, Linda Donnelly, Nadia Elghobashi-Meinhardt, Tao Long, Rich W. Zhou, Yingyuan Sun, Boyuan Wang, Xiaochun Li

Nature. Author manuscript; available in PMC 2023 Jul 13.

Published in final edited form as: Nature. 2022 Jul; 607(7920): 816–822. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04952-2

PMCID:: PMC9404457

Abstract Article PDF–5.6M

Select item 84352884.

EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2

Lucie M. Wolf, Annika M. Lambert, Julie Haenlin, Michael Boutros

J Cell Sci. 2021 Aug 15; 134(16): jcs257790. Published online 2021 Aug 18. doi: 10.1242/jcs.257790

PMCID:: PMC8435288

Abstract Article

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79138306.

De Novo PORCN and ZIC2 Mutations in a Highly Consanguineous Family

Laura Castilla-Vallmanya, Semra Gürsoy, Özlem Giray-Bozkaya, Aina Prat-Planas, Gemma Bullich, Leslie Matalonga, Mónica Centeno-Pla, Raquel Rabionet, Daniel Grinberg, Susanna Balcells, Roser Urreizti

Int J Mol Sci. 2021 Feb; 22(4): 1549. Published online 2021 Feb 4. doi: 10.3390/ijms22041549

PMCID:: PMC7913830

Abstract Article PDF–9.0M

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 70403958.

Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma

Jianyi Li, Guangzhen Wu, Yingkun Xu, Jiatong Li, Ningke Ruan, Yougen Chen, Qi Zhang, Qinghua Xia

Biomed Res Int. 2020; 2020: 2527643. Published online 2020 Feb 13. doi: 10.1155/2020/2527643

PMCID:: PMC7040395

Abstract Article PDF–10M

Select item 63228829.

In vitro reconstitution of Wnt acylation reveals structural determinants of substrate recognition by the acyltransferase human Porcupine

Chul-Jin Lee, Mitra S. Rana, Chanhyung Bae, Yan Li, Anirban Banerjee

J Biol Chem. 2019 Jan 4; 294(1): 231–245. Published online 2018 Nov 12. doi: 10.1074/jbc.RA118.005746

PMCID:: PMC6322882

Abstract Article PDF–4.8M

Select item 556651010.

An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine

James J. Asciolla, Matthew M. Miele, Ronald C. Hendrickson, Marilyn D. Resh

J Biol Chem. 2017 Aug 18; 292(33): 13507–13513. Published online 2017 Jun 27. doi: 10.1074/jbc.C117.800136

PMCID:: PMC5566510

Abstract Article PDF–898K

Select item 549522511.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 466657712.

Expanding the phenotypic spectrum of PORCN variants in two males with syndromic microphthalmia

Paul D Brady, Hilde Van Esch, Nathalie Fieremans, Guy Froyen, Anne Slavotinek, Jan Deprest, Koenraad Devriendt, Joris R Vermeesch

Eur J Hum Genet. 2015 Apr; 23(4): 551–554. Published online 2014 Jul 16. doi: 10.1038/ejhg.2014.135

PMCID:: PMC4666577

Abstract Article PDF–354K

Select item 465026313.

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

B Madan, Z Ke, N Harmston, S Y Ho, A O Frois, J Alam, D A Jeyaraj, V Pendharkar, K Ghosh, I H Virshup, V Manoharan, E H Q Ong, K Sangthongpitag, J Hill, E Petretto, T H Keller, M A Lee, A Matter, D M Virshup

Oncogene. 2016 Apr 28; 35(17): 2197–2207. Published online 2015 Aug 10. doi: 10.1038/onc.2015.280