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Items: 1 to 20 of 51

1.
Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease
Yulong Li, Jiawen Li, Xiaofang Tang, Jingjing Xu, Ru Liu, Lin Jiang, Jian Tian, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan, Xueyan Zhao
BMC Med Genomics. 2024; 17: 22. Published online 2024 Jan 17. doi: 10.1186/s12920-024-01802-0
PMCID:
PMC10795340
AbstractArticlePDF–1.5M
2.
Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets
Filip Mihalič, Caroline Benz, Eszter Kassa, Richard Lindqvist, Leandro Simonetti, Raviteja Inturi, Hanna Aronsson, Eva Andersson, Celestine N. Chi, Norman E. Davey, Anna K. Överby, Per Jemth, Ylva Ivarsson
Nat Commun. 2023; 14: 5636. Published online 2023 Sep 13. doi: 10.1038/s41467-023-41312-8
PMCID:
PMC10499821
AbstractArticlePDF–2.6M
3.
HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins
Jiawen Li, Xiaofang Tang, Jingjing Xu, Ru Liu, Lin Jiang, Lianjun Xu, Jian Tian, Xinxing Feng, Yajie Wu, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan, Xueyan Zhao
BMC Cardiovasc Disord. 2023; 23: 317. Published online 2023 Jun 24. doi: 10.1186/s12872-023-03285-w
PMCID:
PMC10290797
AbstractArticlePDF–1.7M
4.
Expression and prognostic significance of Niemann-Pick C1-Like 1 in colorectal cancer: a retrospective cohort study
Ryuk Jun Kwon, Eun-Ju Park, Sang Yeoup Lee, Youngin Lee, Chungsu Hwang, Choongrak Kim, Young Hye Cho
Lipids Health Dis. 2021; 20: 104. Published online 2021 Sep 12. doi: 10.1186/s12944-021-01539-0
PMCID:
PMC8436523
AbstractArticlePDF–1.3M
5.
Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption
Tao Long, Yang Liu, Yu Qin, Russell A. DeBose-Boyd, Xiaochun Li
Sci Adv. 2021 Aug; 7(34): eabh3997. Published online 2021 Aug 18. doi: 10.1126/sciadv.abh3997
PMCID:
PMC8373123
AbstractArticlePDF–1.2M
6.
The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity
Flaminia Ferri, Simone Carotti, Guido Carpino, Monica Mischitelli, Alfredo Cantafora, Antonio Molinaro, Maria Eva Argenziano, Simona Parisse, Alessandro Corsi, Mara Riminucci, Quirino Lai, Gianluca Mennini, Gustavo Spadetta, Francesco Pugliese, Massimo Rossi, Sergio Morini, Eugenio Gaudio, Stefano Ginanni Corradini
Int J Mol Sci. 2021 Jun; 22(11): 6100. Published online 2021 Jun 5. doi: 10.3390/ijms22116100
PMCID:
PMC8200978
AbstractArticlePDF–1.3M
7.
NPC1L1-dependent transport of 27-alkyne cholesterol in intestinal epithelial cells
Alexander L. Ticho, Nathan Calzadilla, Pooja Malhotra, Hyunjin Lee, Arivarasu Natarajan Anbazhagan, Seema Saksena, Pradeep K. Dudeja, Daesung Lee, Ravinder K. Gill, Waddah A. Alrefai
Am J Physiol Cell Physiol. 2021 May 1; 320(5): C916–C925. Published online 2021 Mar 24. doi: 10.1152/ajpcell.00062.2021
PMCID:
PMC8163569
AbstractArticle
8.
Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
Piyali Saha, Justin L Shumate, Jenna G Caldwell, Nadia Elghobashi-Meinhardt, Albert Lu, Lichao Zhang, Niclas E Olsson, Joshua E Elias, Suzanne R Pfeffer
eLife. 2020; 9: e57089. Published online 2020 May 15. doi: 10.7554/eLife.57089
PMCID:
PMC7228765
AbstractArticlePDF–6.2M
9.
Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity
Gulsum E. Muku, Ann Kusnadi, Guray Kuzu, Rachel Tanos, Iain A. Murray, Krishne Gowda, Shantu Amin, Gary H. Perdew
Lab Invest. Author manuscript; available in PMC 2020 Feb 15.
Published in final edited form as: Lab Invest. 2020 Feb; 100(2): 250–264. Published online 2019 Aug 15. doi: 10.1038/s41374-019-0306-x
PMCID:
PMC6989381
AbstractArticlePDF–2.4M
10.
Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet
Yu Toyoda, Tappei Takada, Yoshihide Yamanashi, Hiroshi Suzuki
Lipids Health Dis. 2019; 18: 234. Published online 2019 Dec 28. doi: 10.1186/s12944-019-1179-0
PMCID:
PMC6935138
AbstractArticlePDF–1.3M
11.
Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice
Youlin Wang, Pan Yang, Bo Zhang, Yao Ding, Shun Lei, Yuning Hou, Xiaoqing Guan, Qingwang Li
Mol Med Rep. 2019 Oct; 20(4): 3224–3232. Published online 2019 Aug 1. doi: 10.3892/mmr.2019.10549
PMCID:
PMC6755247
AbstractArticlePDF–768K
12.
The Niemann–Pick C1-like 1 rs2073547 polymorphism is associated with type 2 diabetes mellitus in a Chinese population
Zhenxing Huang, Ruyin Tan, Liheng Meng, Haiyan Yang, Xinghuan Liang, Yingfen Qin, Zuojie Luo
J Int Med Res. 2019 Sep; 47(9): 4260–4271. Published online 2019 Jul 16. doi: 10.1177/0300060519862099
PMCID:
PMC6753537
AbstractArticlePDF–290K
13.
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease
Sang Bong Ahn, Dae Won Jun, Kiseok Jang, Byung Hoon Lee, Kye Jung Shin
Korean J Intern Med. 2019 Jul; 34(4): 777–784. Published online 2018 Feb 23. doi: 10.3904/kjim.2017.100
PMCID:
PMC6610185
AbstractArticlePDF–2.6M
14.
Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both: A 2 × 2 Factorial Mendelian Randomization Study
Brian A. Ference, Faisal Majeed, Raju Penumetcha, John M. Flack, Robert D. Brook
J Am Coll Cardiol. Author manuscript; available in PMC 2018 Aug 20.
Published in final edited form as: J Am Coll Cardiol. 2015 Apr 21; 65(15): 1552–1561. Published online 2015 Mar 11. doi: 10.1016/j.jacc.2015.02.020
PMCID:
PMC6101243
AbstractArticlePDF–202K
15.
Association between LDL-cholesterol lowering genetic variants and risk of type 2 diabetes
Luca A. Lotta, Stephen. J Sharp, Stephen Burgess, John R. B. Perry, Isobel. D Stewart, Sara M. Willems, Jian’an Luan, Eva Ardanaz, Larraitz Arriola, Beverley Balkau, Heiner Boeing, Panos Deloukas, Nita G Forouhi, Paul W Franks, Sara Grioni, Rudolf Kaaks, Timothy J Key, Carmen Navarro, Peter M Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, Jose-Ramón Quirós, Elio Riboli, Olov Rolandsson, Carlotta Sacerdote, Elena C Salamanca, Nadia Slimani, Annemieke MW Spijkerman, Anne Tjonneland, Rosario Tumino, Daphne L van der A, Yvonne T van der Schouw, Mark I. McCarthy, Inês Barroso, Stephen O’Rahilly, David. B Savage, Naveed Sattar, Claudia Langenberg, Robert. A Scott, Nicholas J. Wareham
JAMA. Author manuscript; available in PMC 2017 Apr 10.
Published in final edited form as: JAMA. 2016 Oct 4; 316(13): 1383–1391. doi: 10.1001/jama.2016.14568
PMCID:
PMC5386134
AbstractArticlePDF–281K
16.
Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis
Tory A. Johnson, Suzanne R. Pfeffer
Mol Biol Cell. 2016 Jun 1; 27(11): 1845–1852. doi: 10.1091/mbc.E16-03-0154
PMCID:
PMC4884074
AbstractArticlePDF–1.1M
17.
The NPC1L1 Polymorphism 1679C>G Is Associated with Gallstone Disease in Chinese Patients
Jian Wu, Wei Cui, Qu Cai, Jian Fei, Sheng-Dao Zhang, Tian-Quan Han, Hai Hu, Zhao-Yan Jiang
PLoS One. 2016; 11(1): e0147562. Published online 2016 Jan 22. doi: 10.1371/journal.pone.0147562
PMCID:
PMC4723254
AbstractArticlePDF–373K
18.
Transcriptional regulation of Niemann-Pick C1-like 1 gene by liver receptor homolog-1
Eui Sup Lee, Hyun Jung Seo, Su Sun BacK, Seung Ho Han, Yeon Ji Jeong, Jin Wook Lee, Soo Young Choi, Kyuhyung Han
BMB Rep. 2015 Sep; 48(9): 513–518. doi: 10.5483/BMBRep.2015.48.9.253
PMCID:
PMC4641235
AbstractArticlePDF–705K
19.
Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
The Myocardial Infarction Genetics Consortium Investigators
N Engl J Med. Author manuscript; available in PMC 2015 May 27.
Published in final edited form as: N Engl J Med. 2014 Nov 27; 371(22): 2072–2082. Published online 2014 Nov 12. doi: 10.1056/NEJMoa1405386
PMCID:
PMC4335708
AbstractArticlePDF–724K
20.
Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels
Ping Xie, Hongling Zhu, Lin Jia, Yinyan Ma, Weiqing Tang, Youlin Wang, Bingzhong Xue, Hang Shi, Liqing Yu
Atherosclerosis. Author manuscript; available in PMC 2015 Dec 1.
Published in final edited form as: Atherosclerosis. 2014 Dec; 237(2): 609–617. Published online 2014 Oct 17. doi: 10.1016/j.atherosclerosis.2014.09.036
PMCID:
PMC4262594
AbstractArticlePDF–1.1M

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