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Select item 110241571.

ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance

Cheol-Jung Lee, Heejung Lee, Seo Ree Kim, Soo-Bin Nam, Ga-Eun Lee, Kyeong Eun Yang, Guk Jin Lee, Sang Hoon Chun, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Sung-Jun Cho, Yong-Yeon Cho

Cell Death Dis. 2024 Apr; 15(4): 274. Published online 2024 Apr 17. doi: 10.1038/s41419-024-06647-0

PMCID:: PMC11024157

Abstract Article PDF–5.2M

Select item 110056892.

CSN6‐SPOP‐HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation

Kai Li, Jiayu Zhang, Haiwen Lyu, Jinneng Yang, Wenxia Wei, Yuzhi Wang, Haidan Luo, Yijing Zhang, Xin Jiang, Hairong Yi, Mengan Wang, Caiyun Zhang, Kang Wu, Lishi Xiao, Weijie Wen, Hui Xu, Guolin Li, Yunle Wan, Fang Yang, Runxiang Yang, Xinhui Fu, Baifu Qin, Zhongguo Zhou, Haipeng Zhang, Mong‐Hong Lee

Adv Sci (Weinh) 2024 Apr; 11(14): 2306827. Published online 2024 Feb 2. doi: 10.1002/advs.202306827

PMCID:: PMC11005689

Abstract Article PDF–9.1M

Select item 108589423.

BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma

Zongdong Yu, Xiang Wu, Jie Zhu, Huan Yan, Yuxuan Li, Hui Zhang, Yeling Zhong, Man Lin, Ganghui Ye, Xinming Li, Jiabei Jin, Kailang Li, Jie Wang, Hui Zhuang, Ting Lin, Jian He, Changjiang Lu, Zeping Xu, Xie Zhang, Hong Li, Xiaofeng Jin

Cell Mol Life Sci. 2024 Dec; 81(1): 82. Published online 2024 Feb 10. doi: 10.1007/s00018-024-05144-z

PMCID:: PMC10858942

Abstract Article PDF–17M

Select item 106964674.

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Nafiseh Sabri, Matthew J. Cuneo, Melissa R. Marzahn, Jihun Lee, Jill J. Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B. Borgia, Jeremy Schmit, Tanja Mittag

J Biol Chem. 2023 Dec; 299(12): 105427. Published online 2023 Nov 4. doi: 10.1016/j.jbc.2023.105427

PMCID:: PMC10696467

Abstract Article PDF–5.1M

Select item 106174365.

Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease

Lichao Zang, Xinyu Yang, Yan Chen, Fan Huang, Yukang Yuan, Xiangjie Chen, Yibo Zuo, Ying Miao, Jin Gu, Hui Guo, Wenxin Xia, Yang Peng, Mengyuan Tang, Ziwei Huang, Yangyang Wang, Jinhong Ma, Jingting Jiang, Wei Zhou, Hui Zheng, Weifeng Shi

J Virol. 2023 Oct; 97(10): e00786-23. Published online 2023 Oct 5. doi: 10.1128/jvi.00786-23

PMCID:: PMC10617436

Abstract Article PDF–2.6M

Select item 106144116.

Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis

Yidong Ge, Jiabei Jin, Gun Chen, Jinyun Li, Meng Ye, Xiaofeng Jin

Cell Commun Signal. 2023; 21: 303. Published online 2023 Oct 30. doi: 10.1186/s12964-023-01342-7

PMCID:: PMC10614411

Abstract Article PDF–6.8M

Select item 104914347.

SPOP targets the immune transcription factor IRF1 for proteasomal degradation

Irene Schwartz, Milica Vunjak, Valentina Budroni, Adriana Cantoran García, Marialaura Mastrovito, Adrian Soderholm, Matthias Hinterndorfer, Melanie de Almeida, Kathrin Hacker, Jingkui Wang, Kimon Froussios, Julian Jude, Thomas Decker, Johannes Zuber, Gijs A Versteeg

eLife. 2023; 12: e89951. Published online 2023 Aug 25. doi: 10.7554/eLife.89951

PMCID:: PMC10491434

Abstract Article PDF–4.3M

Select item 102989268.

Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners

Awa Diop, Paola Pietrangeli, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni

Int J Mol Sci. 2023 Jun; 24(12): 10138. Published online 2023 Jun 14. doi: 10.3390/ijms241210138

PMCID:: PMC10298926

Abstract Article PDF–1.1M

Select item 100661909.

TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks

Jian Ma, Yingke Zhou, Penglin Pan, Haixin Yu, Zixi Wang, Lei Lily Li, Bing Wang, Yuqian Yan, Yunqian Pan, Qi Ye, Tianjie Liu, Xiaoyu Feng, Shan Xu, Ke Wang, Xinyang Wang, Yanlin Jian, Bohan Ma, Yizeng Fan, Yang Gao, Haojie Huang, Lei Li

Nat Commun. 2023; 14: 1810. Published online 2023 Mar 31. doi: 10.1038/s41467-023-37499-5

PMCID:: PMC10066190

Abstract Article PDF–5.6M

Select item 999809310.

Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

F Emil Thomasen, Matthew J Cuneo, Tanja Mittag, Kresten Lindorff-Larsen

eLife. 2023; 12: e84147. Published online 2023 Mar 1. doi: 10.7554/eLife.84147

PMCID:: PMC9998093

Abstract Article PDF–6.1M

Select item 995044611.

SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1–PD-L1 axis

Kun Gao, Qing Shi, Ye Gu, Wanqi Yang, Yuanlong He, Zeheng Lv, Yan Ding, Wenxin Cao, Chenji Wang, Xiaoping Wan

Cell Death Differ. 2023 Feb; 30(2): 475–487. Published online 2022 Dec 8. doi: 10.1038/s41418-022-01097-7

PMCID:: PMC9950446

Abstract Article PDF–4.9M

Select item 980513412.

SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF

Kai Feng, Qing Shi, Dongyue Jiao, Yingji Chen, Wanqi Yang, Ke Su, Yalan Wang, Yan Huang, Pingzhao Zhang, Yao Li, Chenji Wang

Cell Biosci. 2022; 12: 211. Published online 2022 Dec 30. doi: 10.1186/s13578-022-00950-z

PMCID:: PMC9805134

Abstract Article PDF–9.4M

Select item 972786213.

Speckle-type POZ protein could play a potential inhibitory role in human renal cell carcinoma

Zhi Chen, Zuan Li, Chunlin Li, Bingcai Li, Haojian Wang, Deyong Nong, Ximing Li, Guihai Huang, Junhao Lin, Wei Li

BMC Cancer. 2022; 22: 1277. Published online 2022 Dec 7. doi: 10.1186/s12885-022-10340-w

PMCID:: PMC9727862

Abstract Article PDF–2.9M

Select item 969055414.

SPOP in Cancer: Phenomena, Mechanisms and Its Role in Therapeutic Implications

Xiaojuan Yang, Qing Zhu

Genes (Basel) 2022 Nov; 13(11): 2051. Published online 2022 Nov 7. doi: 10.3390/genes13112051

PMCID:: PMC9690554

Abstract Article PDF–2.3M

Select item 953517215.

CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein

Min Dong, Min Qian, Zhengyi Ruan

J Immunother Cancer. 2022; 10(10): e005270. Published online 2022 Oct 5. doi: 10.1136/jitc-2022-005270

Correction in:: J Immunother Cancer. 2023; 11(12): e005270corr1.

PMCID:: PMC9535172

Abstract Article PDF–10M

Select item 948261516.

The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1

Chunli Wei, Yun Liu, Xiaoyan Liu, Jingliang Cheng, Jiewen Fu, Xiuli Xiao, Robb E. Moses, Xiaotao Li, Junjiang Fu

Cell Death Discov. 2022; 8: 389. Published online 2022 Sep 17. doi: 10.1038/s41420-022-01182-3

PMCID:: PMC9482615

Abstract Article PDF–3.0M

Select item 945096517.

Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer

Kun Gao, Qing Shi, Yajuan Liu, Chenji Wang

Autophagy. 2022; 18(8): 2013–2015. Published online 2022 Apr 19. doi: 10.1080/15548627.2022.2062873

PMCID:: PMC9450965

Abstract Article PDF–353K

Select item 942975418.

SPOP promotes cervical cancer progression by inducing the movement of PD-1 away from PD-L1 in spatial localization

Jiangchun Wu, Yong Wu, Qinhao Guo, Siyu chen, Simin Wang, Xiaohua Wu, Jun Zhu, Xingzhu Ju

J Transl Med. 2022; 20: 384. Published online 2022 Aug 30. doi: 10.1186/s12967-022-03574-6

PMCID:: PMC9429754

Abstract Article PDF–3.6M

Select item 934596019.

ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression

Yizeng Fan, Tao Hou, Weichao Dan, Yasheng Zhu, Bo Liu, Yi Wei, Zixi Wang, Yang Gao, Jin Zeng, Lei Li

Cell Death Differ. 2022 Aug; 29(8): 1611–1624. Published online 2022 Feb 22. doi: 10.1038/s41418-022-00951-y

PMCID:: PMC9345960

Abstract Article PDF–5.6M

Select item 925890620.

GLI3 is stabilized by SPOP mutations and promotes castration resistance via functional cooperation with androgen receptor in prostate cancer

Marieke Burleson, Janice J. Deng, Tai Qin, Thu Minh Duong, Yuqian Yan, Xiang Gu, Debodipta Das, Acarizia Easley, Michael A. Liss, P. Renee Yew, Roble Bedolla, Addanki Pratap Kumar, Tim Hui-Ming Huang, Yi Zou, Yidong Chen, Chun-Liang Chen, Haojie Huang, Lu-Zhe Sun, Thomas G. Boyer

Mol Cancer Res. Author manuscript; available in PMC 2022 Jul 6.

Published in final edited form as: Mol Cancer Res. 2022 Jan; 20(1): 62–76. Published online 2021 Oct 5. doi: 10.1158/1541-7786.MCR-21-0108

PMCID:: PMC9258906

Abstract Article PDF–3.2M

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PMC Links for GEO Profiles (Select 132366483) (137)
PMC
Conserved Domain Links for Protein (Select 357197147) (1)
Conserved Domains
Conserved Domain Links for Protein (Select 84579950) (3)
Conserved Domains
AraC family transcriptional regulator [Chania multitudinisentens]
AraC family transcriptional regulator [Chania multitudinisentens]
gi|640471334|ref|WP_024911916.1|

Protein
PREDICTED: Danio rerio si:ch211-200e2.1 (si:ch211-200e2.1), transcript variant X...
PREDICTED: Danio rerio si:ch211-200e2.1 (si:ch211-200e2.1), transcript variant X1, mRNA
gi|1207164582|ref|XM_005174119.4|

Nucleotide

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