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Select item 105757291.

The CTBP2-PCIF1 complex regulates m⁶Am modification of mRNA in head and neck squamous cell carcinoma

Kang Li, Jie Chen, Caihua Zhang, Maosheng Cheng, Shuang Chen, Wei Song, Chunlong Yang, Rongsong Ling, Zhi Chen, Xiaochen Wang, Gan Xiong, Jieyi Ma, Yan Zhu, Quan Yuan, Qi Liu, Liang Peng, Qianming Chen, Demeng Chen

J Clin Invest. 2023 Oct 16; 133(20): e170173. Published online 2023 Oct 16. doi: 10.1172/JCI170173

PMCID:: PMC10575729

Abstract Article PDF–4.1M

Select item 105658762.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 98413284.

Role of PCIF1‐mediated 5′‐cap N6‐methyladeonsine mRNA methylation in colorectal cancer and anti‐PD‐1 immunotherapy

Lingling Wang, Lujing Wu, Zhouting Zhu, Qiong Zhang, Wanyu Li, Gwendolyn Michelle Gonzalez, Yinsheng Wang, Tariq M Rana

EMBO J. 2023 Jan; 42(2): e111673. Published online 2022 Dec 14. doi: 10.15252/embj.2022111673

PMCID:: PMC9841328

Abstract Article PDF–3.3M

Select item 89314295.

Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs

Dan Yu, Nan Dai, Eric J. Wolf, Ivan R. Corrêa, Jr., Jujun Zhou, Tao Wu, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng

J Biol Chem. 2022 Apr; 298(4): 101751. Published online 2022 Feb 19. doi: 10.1016/j.jbc.2022.101751

PMCID:: PMC8931429

Abstract Article PDF–2.1M

Select item 85653536.

The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features

Helena Covelo-Molares, Ales Obrdlik, Ivana Poštulková, Michaela Dohnálková, Pavlína Gregorová, Ranjani Ganji, David Potěšil, Lisa Gawriyski, Markku Varjosalo, Štěpánka Vaňáčová

Nucleic Acids Res. 2021 Nov 8; 49(19): 10895–10910. Published online 2021 Oct 11. doi: 10.1093/nar/gkab900

PMCID:: PMC8565353

Abstract Article PDF–2.3M

Select item 84527647.

HIV reprograms host m⁶Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1

Qiong Zhang, Yuqi Kang, Shaobo Wang, Gwendolyn Michelle Gonzalez, Wanyu Li, Hui Hui, Yinsheng Wang, Tariq M. Rana

Nat Commun. 2021; 12: 5543. Published online 2021 Sep 20. doi: 10.1038/s41467-021-25683-4

PMCID:: PMC8452764

Abstract Article PDF–2.7M

Select item 83074718.

Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-β

Michael A. Tartell, Konstantinos Boulias, Gabriela Brunsting Hoffmann, Louis-Marie Bloyet, Eric Lieberman Greer, Sean P. J. Whelan

Proc Natl Acad Sci U S A. 2021 Jul 20; 118(29): e2025769118. Published online 2021 Jul 15. doi: 10.1073/pnas.2025769118

PMCID:: PMC8307471

Abstract Article PDF–1.8M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 794881510.

Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima

Dan Yu, Gundeep Kaur, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng

J Biol Chem. 2021 Jan-Jun; 296: 100270. Published online 2021 Jan 9. doi: 10.1016/j.jbc.2021.100270

PMCID:: PMC7948815

Abstract Article PDF–1.8M

Select item 690456111.

Atlas of quantitative single-base-resolution N⁶-methyl-adenine methylomes

Casslynn W. Q. Koh, Yeek Teck Goh, W. S. Sho Goh

Nat Commun. 2019; 10: 5636. Published online 2019 Dec 10. doi: 10.1038/s41467-019-13561-z

PMCID:: PMC6904561

Abstract Article PDF–2.5M

Select item 670382212.

Identification of the m⁶Am methyltransferase PCIF1 reveals the location and functions of m⁶Am in the transcriptome

Konstantinos Boulias, Diana Toczydłowska-Socha, Ben R. Hawley, Noa Liberman, Ken Takashima, Sara Zaccara, Théo Guez, Jean-Jacques Vasseur, Françoise Debart, L. Aravind, Samie R. Jaffrey, Eric Lieberman Greer

Mol Cell. Author manuscript; available in PMC 2020 Aug 8.

Published in final edited form as: Mol Cell. 2019 Aug 8; 75(3): 631–643.e8. Published online 2019 Jul 3. doi: 10.1016/j.molcel.2019.06.006

PMCID:: PMC6703822

Abstract Article PDF–1.1M

Select item 668890113.

PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression

Erdem Sendinc, David Valle-Garcia, Abhinav Dhall, Hao Chen, Telmo Henriques, Jose Navarrete-Perea, Wanqiang Sheng, Steven P. Gygi, Karen Adelman, Yang Shi

Mol Cell. Author manuscript; available in PMC 2020 Aug 8.

Published in final edited form as: Mol Cell. 2019 Aug 8; 75(3): 620–630.e9. Published online 2019 Jul 3. doi: 10.1016/j.molcel.2019.05.030

PMCID:: PMC6688901

Abstract Article PDF–1.3M

Select item 631828114.

Cap-specific, terminal N⁶-methylation by a mammalian m⁶Am methyltransferase

Hanxiao Sun, Meiling Zhang, Kai Li, Dongsheng Bai, Chengqi Yi

Cell Res. 2019 Jan; 29(1): 80–82. Published online 2018 Nov 28. doi: 10.1038/s41422-018-0117-4

PMCID:: PMC6318281

Article PDF–910K

Select item 537440615.

The Phosphorylation of PDX-1 by Protein Kinase CK2 Is Crucial for Its Stability

Sabrina Klein, Rui Meng, Mathias Montenarh, Claudia Götz

Pharmaceuticals (Basel) 2017 Mar; 10(1): 2. Published online 2016 Dec 28. doi: 10.3390/ph10010002

PMCID:: PMC5374406

Abstract Article PDF–2.7M

Select item 319082616.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 288167618.

Common variants at 30 loci contribute to polygenic dyslipidemia

Sekar Kathiresan, Cristen J Willer, Gina Peloso, Serkalem Demissie, Kiran Musunuru, Eric Schadt, Kaplan Lee, Derrick Bennett, Yun Li, Toshiko Tanaka, Benjamin F Voight, Lori L Bonnycastle, Anne U Jackson, Gabriel Crawford, Aarti Surti, Candace Guiducci, Noel Burtt, Sarah Parish, Robert Clarke, Diana Zelenika, Kari A Kubalanza, Mario A Morken, Laura J Scott, Heather M Stringham, Pilar Galan, Amy J Swift, Johanna Kuusisto, Richard N Bergman, Jouko Sundvall, Markku Laakso, Luigi Ferrucci, Paul Scheet, Serena Sanna, Manuela Uda, Qiong Yang, Kathryn Lunetta, Josee Dupuis, Paul I deBakker, Christopher J O’Donnell, John C Chambers, Jaspal S Kooner, Serge Hercberg, Pierre Meneton, Edward G Lakatta, Angelo Scuteri, David Schlessinger, Jaakko Tuomilehto, Francis S Collins, Leif Groop, David Altshuler, Rory Collins, G Mark Lathrop, Olle Melander, Veikko Salomaa, Leena Peltonen, Marju Orho-Melander, Jose M Ordovas, Michael Boehnke, Gonçalo R Abecasis, Karen L Mohlke, L Adrienne Cupples

Nat Genet. Author manuscript; available in PMC 2010 Jun 7.

Published in final edited form as: Nat Genet. 2009 Jan; 41(1): 56–65. Published online 2008 Dec 7. doi: 10.1038/ng.291

PMCID:: PMC2881676

Abstract Article PDF–1.4M

Select item 52892819.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 40044820.

Identification of PCIF1, a POZ Domain Protein That Inhibits PDX-1 (MODY4) Transcriptional Activity

Aihua Liu, Biva M. Desai, Doris A. Stoffers

Mol Cell Biol. 2004 May; 24(10): 4372–4383. doi: 10.1128/MCB.24.10.4372-4383.2004

PMCID:: PMC400448

Abstract Article PDF–711K

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