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Select item 110407841.

CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1

Kai Lei, Ruihao Liang, Jialu Liang, Nan Lu, Jing Huang, Ke Xu, Binghua Tan, Kexi Wang, Yicheng Liang, Wenjian Wang, Huayue Lin, Minghui Wang

J Exp Clin Cancer Res. 2024; 43: 124. Published online 2024 Apr 24. doi: 10.1186/s13046-024-03054-3

PMCID:: PMC11040784

Abstract Article PDF–18M

Select item 93687582.

Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms

Silvia Cardarelli, Adriana Erica Miele, Federica Campolo, Mara Massimi, Patrizia Mancini, Stefano Biagioni, Fabio Naro, Mauro Giorgi, Michele Saliola

Int J Mol Sci. 2022 Aug; 23(15): 8587. Published online 2022 Aug 2. doi: 10.3390/ijms23158587

PMCID:: PMC9368758

Abstract Article PDF–2.3M

Select item 89662013.

Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

Daniela Puzzo, Carla Loreto, Salvatore Giunta, Giuseppe Musumeci, Giuseppina Frasca, Maria Vittoria Podda, Ottavio Arancio, Agostino Palmeri

Neurobiol Aging. Author manuscript; available in PMC 2022 Mar 30.

Published in final edited form as: Neurobiol Aging. 2014 Mar; 35(3): 520–531. Published online 2013 Oct 7. doi: 10.1016/j.neurobiolaging.2013.09.002

PMCID:: PMC8966201

Abstract Article PDF–1.0M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80012735.

Muscle Damage in Systemic Sclerosis and CXCL10: The Potential Therapeutic Role of PDE5 Inhibition

Clarissa Corinaldesi, Rebecca L. Ross, Giuseppina Abignano, Cristina Antinozzi, Francesco Marampon, Luigi di Luigi, Maya H. Buch, Valeria Riccieri, Andrea Lenzi, Clara Crescioli, Francesco Del Galdo

Int J Mol Sci. 2021 Mar; 22(6): 2894. Published online 2021 Mar 12. doi: 10.3390/ijms22062894

PMCID:: PMC8001273

Abstract Article PDF–1.6M

Select item 77015716.

Changes in the expression and function of the PDE5 pathway in the obstructed urinary bladder

Weixiang He, Han Xiang, Daoquan Liu, Jianmin Liu, Mingzhou Li, Qian Wang, Qiaofeng Qian, Yan Li, Xun Fu, Ping Chen, Yuming Guo, Guang Zeng, Zhonghua Wu, Daxing Zhan, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang

J Cell Mol Med. 2020 Nov; 24(22): 13181–13195. Published online 2020 Oct 3. doi: 10.1111/jcmm.15926

PMCID:: PMC7701571

Abstract Article PDF–3.2M

Select item 74605607.

Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death against Human Non-Small Cell Lung Cancers

Ya-Ching Chang, Yu-Ling Tseng, Wohn-Jenn Leu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Jui-Ling Hsu, Duen-Ren Hou, Jih-Hwa Guh

Int J Mol Sci. 2020 Aug; 21(16): 5608. Published online 2020 Aug 5. doi: 10.3390/ijms21165608

PMCID:: PMC7460560

Abstract Article PDF–3.4M

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 67041199.

Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms

Valeriana Cesarini, Calogera Pisano, Gabriele Rossi, Carmela Rita Balistreri, Flavia Botti, Giorgio Antonelli, Giovanni Ruvolo, Emmanuele A. Jannini, Susanna Dolci

Sci Rep. 2019; 9: 12206. Published online 2019 Aug 21. doi: 10.1038/s41598-019-48432-6

PMCID:: PMC6704119

Abstract Article PDF–3.1M

Select item 654647710.

RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

Masashi Mukohda, Shi Fang, Jing Wu, Larry N. Agbor, Anand R. Nair, Stella-Rita C. Ibeawuchi, Chunyan Hu, Xuebo Liu, Ko-Ting Lu, Deng-Fu Guo, Deborah R. Davis, Henry L. Keen, Frederick W. Quelle, Curt D. Sigmund

J Clin Invest. 2019 Jun 3; 129(6): 2318–2332. Published online 2019 May 6. doi: 10.1172/JCI123462

PMCID:: PMC6546477

Abstract Article PDF–5.4M

Select item 616668211.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 543489612.

Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux

Anna Subbotina, Aina W. Ravna, Roy A. Lysaa, Ruben Abagyan, Ryszard Bugno, Georg Sager

J Pharm Pharmacol. 2017 Jun; 69(6): 675–683. Published online 2017 Feb 17. doi: 10.1111/jphp.12693

PMCID:: PMC5434896

Abstract Article PDF–785K

Select item 535509113.

Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome

Valeriana Cesarini, Maurizio Martini, Lucia Ricci Vitiani, Giovanni Luca Gravina, Silvia Di Agostino, Grazia Graziani, Quintino Giorgio D'Alessandris, Roberto Pallini, Luigi M Larocca, Pellegrino Rossi, Emmanuele A Jannini, Susanna Dolci

Oncotarget. 2017 Feb 21; 8(8): 13223–13239. Published online 2017 Jan 14. doi: 10.18632/oncotarget.14656

PMCID:: PMC5355091

Abstract Article PDF–9.1M

Select item 492788414.

PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease

Andrew F. Teich, Mikako Sakurai, Mitesh Patel, Cameron Holman, Faisal Saeed, Jole Fiorito, Ottavio Arancio

J Alzheimers Dis. 2016; 52(1): 295–302. Prepublished online 2016 Mar 9. Published online 2016 Apr 26. doi: 10.3233/JAD-151104

PMCID:: PMC4927884

Abstract Article PDF–30M

Select item 486917015.

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, Konstantinos Koutroumpas, Thanh-Minh T. Nguyen, Yves Texier, Sylvia E. C. van Beersum, Nicola Horn, Jason R. Willer, Dorus A. Mans, Gerard Dougherty, Ideke J. C. Lamers, Karlien L. M. Coene, Heleen H. Arts, Matthew J. Betts, Tina Beyer, Emine Bolat, Christian Johannes Gloeckner, Khatera Haidari, Lisette Hetterschijt, Daniela Iaconis, Dagan Jenkins, Franziska Klose, Barbara Knapp, Brooke Latour, Stef J. F. Letteboer, Carlo L. Marcelis, Dragana Mitic, Manuela Morleo, Machteld M. Oud, Moniek Riemersma, Susan Rix, Paulien A. Terhal, Grischa Toedt, Teunis J. P. van Dam, Erik de Vrieze, Yasmin Wissinger, Ka Man Wu, Gordana Apic, Philip L. Beales, Oliver E. Blacque, Toby J. Gibson, Martijn A. Huynen, Nicholas Katsanis, Hannie Kremer, Heymut Omran, Erwin van Wijk, Uwe Wolfrum, François Kepes, Erica E. Davis, Brunella Franco, Rachel H. Giles, Marius Ueffing, Robert B. Russell, Ronald Roepman, UK10K Rare Diseases Group

Nat Commun. 2016; 7: 11491. Published online 2016 May 13. doi: 10.1038/ncomms11491

PMCID:: PMC4869170

Abstract Article PDF–2.0M

Select item 469499816.

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

Nan Li, Xi Chen, Bing Zhu, Verónica Ramírez-Alcántara, Joshua C. Canzoneri, Kevin Lee, Sara Sigler, Bernard Gary, Yonghe Li, Wei Zhang, Mary P. Moyer, E. Alan Salter, Andrzej Wierzbicki, Adam B. Keeton, Gary A. Piazza

Oncotarget. 2015 Sep 29; 6(29): 27403–27415. Published online 2015 Jul 25. doi: 10.18632/oncotarget.4741

PMCID:: PMC4694998

Abstract Article PDF–2.8M

Select item 467474117.

Upregulation of Phosphodiesterase type 5 in the Hyperplastic Prostate

Wenhao Zhang, Ning Zang, Yaoming Jiang, Ping Chen, Xinghuan Wang, Xinhua Zhang

Sci Rep. 2015; 5: 17888. Published online 2015 Dec 10. doi: 10.1038/srep17888

PMCID:: PMC4674741

Abstract Article PDF–1.5M

Select item 431443818.

Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage

Emma E. M. Knowles, D. Reese McKay, Jack W. Kent, Jr, Emma Sprooten, Melanie A. Carless, Joanne E. Curran, Marcio A. A. de Almeida, Thomas D. Dyer, Harald H. H. Göring, Rene Olvera, Ravi Duggirala, Peter Fox, Laura Almasy, John Blangero, David. C. Glahn

Am J Psychiatry. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Am J Psychiatry. 2015 Feb 1; 172(2): 190–199. Published online 2014 Oct 31. doi: 10.1176/appi.ajp.2014.14030311

PMCID:: PMC4314438

Abstract Article PDF–460K

Select item 417248519.

Role of Ser102 and Ser104 as Regulators of cGMP Hydrolysis by PDE5A

Julie Carøe Nordgaard, Lars Schack Kruse, Steen Gammeltoft, Christina Rostrup Kruuse

PLoS One. 2014; 9(9): e107627. Published online 2014 Sep 23. doi: 10.1371/journal.pone.0107627

PMCID:: PMC4172485

Abstract Article PDF–526K

Select item 379111020.

Ventricular phosphodiesterase 5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice

Peter Pokreisz, Sara Vandenwijngaert, Virginie Bito, An Van den Bergh, Ilse Lenaerts, Cornelius Busch, Glenn Marsboom, Olivier Gheysens, Pieter Vermeersch, Liesbeth Biesmans, Xiaoshun Liu, Hilde Gillijns, Marijke Pellens, Alfons Van Lommel, Emmanuel Buys, Luc Schoonjans, Johan Vanhaecke, Erik Verbeken, Karin Sipido, Paul Herijgers, Kenneth D. Bloch, Stefan Janssens

Circulation. Author manuscript; available in PMC 2013 Oct 5.

Published in final edited form as: Circulation. 2009 Jan 27; 119(3): 408–416. Published online 2009 Jan 12. doi: 10.1161/CIRCULATIONAHA.108.822072

PMCID:: PMC3791110

Abstract Article PDF–5.0M

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