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Select item 111670881.

TIGIT⁺Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre

Natalie M. Edner, Luke P. Houghton, Elisavet Ntavli, Chloe Rees-Spear, Lina Petersone, Chunjing Wang, Astrid Fabri, Yassin Elfaki, Andrea Rueda Gonzalez, Rachel Brown, Kai Kisand, Pärt Peterson, Laura E. McCoy, Lucy S. K. Walker

Front Immunol. 2024; 15: 1395684. Published online 2024 May 29. doi: 10.3389/fimmu.2024.1395684

PMCID:: PMC11167088

Abstract Article PDF–6.5M

Select item 110292252.

Immunoreceptor TIGIT inhibits the cytotoxicity of human cytokine-induced killer cells by interacting with CD155

Baofu Zhang, Weina Zhao, Huizhong Li, Yuanyuan Chen, Hui Tian, Liantao Li, Longzhen Zhang, Chao Gao, Junnian Zheng

Cancer Immunol Immunother. 2016 Mar; 65(3): 305–314. Published online 2016 Feb 3. doi: 10.1007/s00262-016-1799-4

PMCID:: PMC11029225

Abstract Article PDF–1.7M

Select item 109923033.

COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade

Kyle Hansen, Sandeep Kumar, Kathryn Logronio, Sarah Whelan, Samir Qurashi, Hsin-Yuan Cheng, Andrew Drake, Margaret Tang, Patrick Wall, David Bernados, Ling Leung, Eran Ophir, Zoya Alteber, Gady Cojocaru, Moran Galperin, Masha Frenkel, Mark White, John Hunter, Spencer C. Liang, Maya F. Kotturi

Cancer Immunol Immunother. 2021 Dec; 70(12): 3525–3540. Published online 2021 Apr 26. doi: 10.1007/s00262-021-02921-8

PMCID:: PMC10992303

Abstract Article PDF–2.4M

Select item 109914654.

Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis

Guanfang Liu, Qi Zhang, Jingying Yang, Xiaomin Li, Luhua Xian, Wenmin Li, Ting Lin, Juan Cheng, Qiwen Lin, Xiuzhang Xu, Qin Li, Yu Lin, Maohua Zhou, Erxia Shen

Cancer Immunol Immunother. 2022 Feb; 71(2): 277–287. Published online 2021 Jun 15. doi: 10.1007/s00262-021-02978-5

Correction in:: Cancer Immunol Immunother. 2023 Aug; 72(8): 2873.

PMCID:: PMC10991465

Abstract Article PDF–3.1M

Select item 107854245.

The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling

Mingyao Huang, Xiaoqin Yu, Qing Wang, Zirong Jiang, Xiaofen Li, Wei Chen, Chuangui Song

Cell Commun Signal. 2024; 22: 35. Published online 2024 Jan 12. doi: 10.1186/s12964-023-01455-z

PMCID:: PMC10785424

Abstract Article PDF–7.6M

Select item 104553956.

CD155 and Its Receptors as Targets for Cancer Therapy

Rossella Paolini, Rosa Molfetta

Int J Mol Sci. 2023 Aug; 24(16): 12958. Published online 2023 Aug 19. doi: 10.3390/ijms241612958

PMCID:: PMC10455395

Abstract Article PDF–1.2M

Select item 104391147.

TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation

Jonathan D. Worboys, Katherine N. Vowell, Roseanna K. Hare, Ashley R. Ambrose, Margherita Bertuzzi, Michael A. Conner, Florence P. Patel, William H. Zammit, Judit Gali-Moya, Khodor S. Hazime, Katherine L. Jones, Camille Rey, Stipan Jonjic, Tihana Lenac Rovis, Gillian M. Tannahill, Gabriela Dos Santos Cruz De Matos, Jeremy D. Waight, Daniel M. Davis

Nat Commun. 2023; 14: 5016. Published online 2023 Aug 18. doi: 10.1038/s41467-023-40755-3

PMCID:: PMC10439114

Abstract Article PDF–8.2M

Select item 104232478.

Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma

Takeshi Iwasaki, Kazuhiko Hayashi, Michiko Matsushita, Daisuke Nonaka, Takamasa Matsumoto, Midori Taniguchi, Satoshi Kuwamoto, Yoshihisa Umekita, Yoshinao Oda

Sci Rep. 2023; 13: 13114. Published online 2023 Aug 12. doi: 10.1038/s41598-023-40050-7

PMCID:: PMC10423247

Abstract Article PDF–1.8M

Select item 103882749.

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy

Francesca Arruga, Marta Rubin, Despoina Papazoglou, Andrea Iannello, Nikolaos Ioannou, Riccardo Moia, Davide Rossi, Gianluca Gaidano, Marta Coscia, Luca Laurenti, Giovanni D’Arena, John N. Allan, Richard R. Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio

Haematologica. 2023 Aug 1; 108(8): 2101–2115. Published online 2023 Jan 19. doi: 10.3324/haematol.2022.282177

PMCID:: PMC10388274

Abstract Article PDF–3.8M

Select item 1037202810.

TIGIT, a novel immune checkpoint therapy for melanoma

Wei Tang, Jun Chen, Tianlong Ji, Xiufeng Cong

Cell Death Dis. 2023 Jul; 14(7): 466. Published online 2023 Jul 26. doi: 10.1038/s41419-023-05961-3

PMCID:: PMC10372028

Abstract Article PDF–1.1M

Select item 963329511.

CD155 mutation (Ala67Thr) increases the binding affinity for and the signaling via an inhibitory immunoreceptor TIGIT

Tomohei Matsuo, Akiko Iguchi‐Manaka, Akira Shibuya, Kazuko Shibuya

Cancer Sci. 2022 Nov; 113(11): 4001–4004. Published online 2022 Aug 30. doi: 10.1111/cas.15526

PMCID:: PMC9633295

Abstract Article PDF–2.3M

Select item 956690612.

Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis

Hiromitsu Asashima, Pierre-Paul Axisa, Thi Hong Giang Pham, Erin E. Longbrake, William E. Ruff, Nikhil Lele, Inessa Cohen, Khadir Raddassi, Tomokazu S. Sumida, David A. Hafler

J Clin Invest. 2022 Oct 17; 132(20): e156254. Published online 2022 Oct 17. doi: 10.1172/JCI156254

PMCID:: PMC9566906

Abstract Article PDF–4.6M

Select item 953250613.

Prognostic value of TIGIT in East Asian patients with solid cancers: A systematic review, meta-analysis and pancancer analysis

Sicong Li, Lanxing Li, Tianyan Pan, Xiaoqun Li, Yujia Tong, Yongdong Jin

Front Immunol. 2022; 13: 977016. Published online 2022 Sep 21. doi: 10.3389/fimmu.2022.977016

PMCID:: PMC9532506

Abstract Article PDF–12M

Select item 951394414.

TIGIT is the central player in T-cell suppression associated with CAR T-cell relapse in mantle cell lymphoma

Vivian Changying Jiang, Dapeng Hao, Preetesh Jain, Yijing Li, Qingsong Cai, Yixin Yao, Lei Nie, Yang Liu, Jingling Jin, Wei Wang, Heng-Huan Lee, Yuxuan Che, Enyu Dai, Guangchun Han, Ruiping Wang, Kunal Rai, Andrew Futreal, Christopher Flowers, Linghua Wang, Michael Wang

Mol Cancer. 2022; 21: 185. Published online 2022 Sep 26. doi: 10.1186/s12943-022-01655-0

PMCID:: PMC9513944

Abstract Article PDF–9.3M

Select item 937711315.

Expression of T-cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif domains (TIGIT) in anaplastic thyroid carcinoma

Tadao Nakazawa, Takuya Nagasaka, Keita Yoshida, Atsuko Hasegawa, Feng Guo, Di Wu, Kenzo Hiroshima, Ryohei Katoh

BMC Endocr Disord. 2022; 22: 204. Published online 2022 Aug 15. doi: 10.1186/s12902-022-01113-4

PMCID:: PMC9377113

Abstract Article PDF–3.1M

Select item 936617616.

Increased frequency of TIGIT+ CD4 T Cell subset in autoantibody-positive first-degree relatives of patients with rheumatoid arthritis

Vidyanand Anaparti, Stacy Tanner, Christine Zhang, Liam O’Neil, Irene Smolik, Xiaobo Meng, Aaron J. Marshall, Hani El-Gabalawy

Front Immunol. 2022; 13: 932627. Published online 2022 Jul 28. doi: 10.3389/fimmu.2022.932627

PMCID:: PMC9366176

Abstract Article PDF–1.6M

Select item 935705717.

Sequential single cell transcriptional and protein marker profiling reveals TIGIT as a marker of CD19 CAR-T cell dysfunction in patients with non-Hodgkin’s lymphoma

Zachary Jackson, Changjin Hong, Robert Schauner, Boro Dropulic, Paolo F. Caimi, Marcos de Lima, Maria Florencia Giraudo, Kalpana Gupta, Jane S. Reese, Tae Hyun Hwang, David N. Wald

Cancer Discov. Author manuscript; available in PMC 2023 Feb 5.

Published in final edited form as: Cancer Discov. 2022 Aug 5; 12(8): 1886–1903. doi: 10.1158/2159-8290.CD-21-1586

PMCID:: PMC9357057

Abstract Article PDF–2.9M

Select item 929995018.

CD155/TIGIT signalling plays a vital role in the regulation of bone marrow mesenchymal stem cell–induced natural killer–cell exhaustion in multiple myeloma

Zhao‐Yun Liu, Ling Deng, Yue Jia, Hui Liu, Kai Ding, Wei Wang, Hongkai Zhang, Rong Fu

Clin Transl Med. 2022 Jul; 12(7): e861. Published online 2022 Jul 20. doi: 10.1002/ctm2.861

PMCID:: PMC9299950

Article PDF–1.5M

Select item 928712419.

Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8⁺ T cell responses

Karl L. Banta, Xiaozheng Xu, Avantika S. Chitre, Amelia Au-Yeung, Chikara Takahashi, William E. O’Gorman, Thomas D. Wu, Stephanie Mittman, Rafael Cubas, Laetitia Comps-Agrar, Amit Fulzele, Eric J. Bennett, Jane L. Grogan, Enfu Hui, Eugene Y. Chiang, Ira Mellman

Immunity. Author manuscript; available in PMC 2022 Jul 16.

Published in final edited form as: Immunity. 2022 Mar 8; 55(3): 512–526.e9. doi: 10.1016/j.immuni.2022.02.005

PMCID:: PMC9287124

Abstract Article PDF–2.6M

Select item 928417020.

TIGIT/CD47 dual high expression predicts prognosis and is associated with immunotherapy response in lung squamous cell carcinoma

Yue Peng, Bin Qiu, Fengwei Tan, Jiachen Xu, Fenglong Bie, Huayu He, Lei Liu, He Tian, Guangyu Bai, Bolun Zhou, Yuan Li, Qilin Huai, Zhenlin Yang, Shugeng Gao

Thorac Cancer. 2022 Jul; 13(14): 2014–2023. Published online 2022 May 24. doi: 10.1111/1759-7714.14478

PMCID:: PMC9284170

Abstract Article PDF–3.8M

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PMC Links for GEO Profiles (Select 132382754) (84)
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Taxonomy Links for Gene (Select 6882) (1)
Taxonomy
transcription initiation factor TFIID subunit 11 isoform 2 [Homo sapiens]
transcription initiation factor TFIID subunit 11 isoform 2 [Homo sapiens]
gi|394953994|ref|NP_001257417.1|

Protein
PREDICTED: Homo sapiens TATA-box binding protein associated factor 11 (TAF11), t...
PREDICTED: Homo sapiens TATA-box binding protein associated factor 11 (TAF11), transcript variant X1, mRNA
gi|2462610256|ref|XM_054356268.1|

Nucleotide

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