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Items: 1 to 20 of 84

1.
Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Remington E Schmidt, Brianna M Bembenek, Zoey B Temesgen, Zhiquan Wang, Federico Innocenti, Deborah Stroka, Robert B Diasio, Carlo R Largiadèr, Steven M Offer
eLife. 2024; 13: RP94075. Published online 2024 Apr 30. doi: 10.7554/eLife.94075
PMCID:
PMC11060711
AbstractArticlePDF–1.0M
2.
Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity
Romain Larrue, Sandy Fellah, Benjamin Hennart, Naoual Sabaouni, Nihad Boukrout, Cynthia Van der Hauwaert, Clément Delage, Meyling Cheok, Michaël Perrais, Christelle Cauffiez, Delphine Allorge, Nicolas Pottier
Pharmacogenomics J. 2024; 24(1): 1. Published online 2024 Jan 12. doi: 10.1038/s41397-023-00322-x
PMCID:
PMC10786722
AbstractArticlePDF–814K
3.
Genetic Variation in miR-27a Is Associated with Fluoropyrimidine-Associated Toxicity in Patients with Dihydropyrimidine Dehydrogenase Variants after Genotype-Guided Dose Reduction
Samantha Medwid, Theodore J. Wigle, Cameron Ross, Richard B. Kim
Int J Mol Sci. 2023 Sep; 24(17): 13284. Published online 2023 Aug 27. doi: 10.3390/ijms241713284
PMCID:
PMC10487873
AbstractArticlePDF–613K
4.
Impact of renal impairment on dihydropyrimidine dehydrogenase (DPD) phenotyping
B. Royer, M. Launay, J. Ciccolini, L. Derain, F. Parant, F. Thomas, J. Guitton
ESMO Open. 2023 Jun; 8(3): 101577. Published online 2023 May 31. doi: 10.1016/j.esmoop.2023.101577
PMCID:
PMC10265596
AbstractArticlePDF–498K
5.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
6.
Allelic Frequency of DPYD Genetic Variants in Patients With Cancer in Spain: The PhotoDPYD Study
Marta Miarons, Alba Manzaneque Gordón, Pau Riera, Fernando Gutiérrez Nicolás, in Collaboration with the RedDPYD Research Group with the Spanish Society of Hospital Pharmacy (SEFH)
Oncologist. 2023 May; 28(5): e304–e308. Published online 2023 Apr 4. doi: 10.1093/oncolo/oyad077
PMCID:
PMC10166167
AbstractArticlePDF–2.5M
7.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
8.
Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine‐induced toxicity in an Asian population
Masashi Kanai, Takahisa Kawaguchi, Masahito Kotaka, Dai Manaka, Junichi Hasegawa, Akinori Takagane, Yoshinori Munemoto, Takeshi Kato, Tetsuya Eto, Tetsuo Touyama, Takanori Matsui, Katsunori Shinozaki, Shigemi Matsumoto, Tsunekazu Mizushima, Masaki Mori, Junichi Sakamoto, Atsushi Ohtsu, Takayuki Yoshino, Shigetoyo Saji, Fumihiko Matsuda
Cancer Med. 2023 Apr; 12(7): 7808–7814. Published online 2022 Dec 16. doi: 10.1002/cam4.5541
PMCID:
PMC10134304
AbstractArticlePDF–196K
9.
FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia
Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen
J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0
PMCID:
PMC9922468
AbstractArticlePDF–4.9M
10.
DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation
Theodore J. Wigle, Samantha Medwid, Cameron Ross, Ute I. Schwarz, Richard B. Kim
Curr Oncol. 2023 Jan; 30(1): 663–672. Published online 2023 Jan 4. doi: 10.3390/curroncol30010051
PMCID:
PMC9857685
AbstractArticlePDF–427K
11.
Pharmacogenetic Study of the Dihydropyridine Dehydrogenase Gene in Jordanian Patients with Colorectal Cancer
Nusaiba A. Almashagbah, Amjad A. Mahasneh, Khaldon G. Bodoor
Asian Pac J Cancer Prev. 2022 Sep; 23(9): 3061–3069. doi: 10.31557/APJCP.2022.23.9.3061
PMCID:
PMC9810321
AbstractArticlePDF–773K
12.
Nucleic Acid Metabolizing Enzyme Levels Predict Chemotherapy Effects in Advanced and Recurrent Colorectal Cancer
Mitsuru Watanabe, Kenji Katsumata, Tetsuo Sumi, Tetsuo Ishizaki, Masanobu Enomoto, Masatoshi Shigoka, Takahiro Wada, Hiroshi Kuwabara, Junichi Mazaki, Kenta Kasahara, Tomoya Tago, Ryutaro Udo, Yuichi Nagakawa, Shigeyuki Kawachi, Akihiko Tsuchida
Asian Pac J Cancer Prev. 2022 Mar; 23(3): 1000–1011. doi: 10.31557/APJCP.2022.23.3.1005
PMCID:
PMC9360946
AbstractArticlePDF–318K
13.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
14.
Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines
P. García-Alfonso, M. Saiz-Rodríguez, R. Mondéjar, J. Salazar, D. Páez, A. M. Borobia, M. J. Safont, I. García-García, R. Colomer, X. García-González, M. J. Herrero, L. A. López-Fernández, F. Abad-Santos
Clin Transl Oncol. 2022; 24(3): 483–494. Published online 2021 Nov 13. doi: 10.1007/s12094-021-02708-4
PMCID:
PMC8885558
AbstractArticlePDF–926K
15.
Dihydropyrimidine dehydrogenase (DPYD) gene c.1627A>G A/G and G/G genotypes are risk factors for lymph node metastasis and distant metastasis of colorectal cancer
Juanzi Zeng, Heming Wu, Qingyan Huang, Jiaquan Li, Zhikang Yu, Zhixiong Zhong
J Clin Lab Anal. 2021 Nov; 35(11): e24023. Published online 2021 Oct 6. doi: 10.1002/jcla.24023
PMCID:
PMC8605172
AbstractArticlePDF–421K
16.
DPYD Genotyping in Patients Who Have Planned Cancer Treatment With Fluoropyrimidines: A Health Technology Assessment
Ontario Health (Quality)
Ont Health Technol Assess Ser. 2021; 21(14): 1–186. Published online 2021 Aug 12.
PMCID:
PMC8382304
AbstractArticlePDF–2.6M
17.
DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer
Hiroyuki Kato, Aya Naiki-Ito, Shugo Suzuki, Shingo Inaguma, Masayuki Komura, Kenju Nakao, Taku Naiki, Kenta Kachi, Akihisa Kato, Yoichi Matsuo, Satoru Takahashi
Carcinogenesis. 2021 Jul; 42(7): 940–950. Published online 2021 Feb 26. doi: 10.1093/carcin/bgab017
PMCID:
PMC8283735
AbstractArticlePDF–20M
18.
Case report: severe toxicity in an African–American patient receiving FOLFOX carrying uncommon allelic variants in DPYD
Tristan M Sissung, Lisa Cordes, Cody J Peer, Shruti Gandhy, Jason Redman, Julius Strauss, William D Figg
Pharmacogenomics. 2021 Jan; 22(2): 81–85. Published online 2020 Dec 11. doi: 10.2217/pgs-2020-0120
PMCID:
PMC7831885
AbstractArticlePDF–426K
19.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
20.
Evaluation of adverse effects of chemotherapy regimens of 5-fluoropyrimidines derivatives and their association with DPYD polymorphisms in colorectal cancer patients
Reza Negarandeh, Ebrahim Salehifar, Fatemeh Saghafi, Hossein Jalali, Ghasem Janbabaei, Mohammad Javad Abdhaghighi, Anahita Nosrati
BMC Cancer. 2020; 20: 560. Published online 2020 Jun 16. doi: 10.1186/s12885-020-06904-3
PMCID:
PMC7298798
AbstractArticlePDF–278K

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