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Select item 111601081.

Protein kinase C‐δ regulates the stability of hypoxia‐inducible factor‐1α under hypoxia

Ji‐Won Lee, Jeong Ae Park, Se‐Hee Kim, Ji Hae Seo, Kyung‐Joon Lim, Joo‐Won Jeong, Chul‐Ho Jeong, Kwang‐Hoon Chun, Seung‐Ki Lee, Young‐Guen Kwon, Kyu‐Won Kim

Cancer Sci. 2007 Sep; 98(9): 1476–1481. Published online 2007 Jun 30. doi: 10.1111/j.1349-7006.2007.00535.x

PMCID:: PMC11160108

Abstract Article PDF–527K

Select item 110341842.

Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line

Angel García-Lora, Marisol Martinez, Susana Pedrinaci, Federico Garrido

Cancer Immunol Immunother. 2003 Jan; 52(1): 59–64. Published online 2002 Oct 17. doi: 10.1007/s00262-002-0336-9

PMCID:: PMC11034184

Abstract Article PDF–327K

Select item 108603013.

Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression

Yujiao Deng, Zhanwu Hou, Yizhen Li, Ming Yi, Ying Wu, Yi Zheng, Fei Yang, Guansheng Zhong, Qian Hao, Zhen Zhai, Meng Wang, Xiaobin Ma, Huafeng Kang, Fanpu Ji, Chenfang Dong, Huadong Liu, Zhijun Dai

Cell Commun Signal. 2024; 22: 115. Published online 2024 Feb 12. doi: 10.1186/s12964-024-01487-z

PMCID:: PMC10860301

Abstract Article PDF–13M

Select item 107457014.

Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer

Mehdi Chaib, Jeremiah R. Holt, Emilie L. Fisher, Laura M. Sipe, Margaret S. Bohm, Sydney C. Joseph, Boston W. Simmons, Samson Eugin Simon, Johnathan R. Yarbro, Ubaid Tanveer, Jessica L. Halle, James A. Carson, T.J. Hollingsworth, QingQing Wei, Jeffrey C. Rathmell, Paul G. Thomas, D. Neil Hayes, Liza Makowski

Sci Adv. 2023 Dec 22; 9(51): eadd3231. Published online 2023 Dec 22. doi: 10.1126/sciadv.add3231

PMCID:: PMC10745701

Abstract Article PDF–2.0M

Select item 106068205.

Thrombin-Induced COX-2 Expression and PGE₂ Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation

Chien-Chung Yang, I-Ta Lee, Yan-Jyun Lin, Wen-Bin Wu, Li-Der Hsiao, Chuen-Mao Yang

Int J Mol Sci. 2023 Oct; 24(20): 15130. Published online 2023 Oct 13. doi: 10.3390/ijms242015130

PMCID:: PMC10606820

Abstract Article PDF–5.9M

Select item 105198286.

Metabolic reprogramming contributes to radioprotection by protein kinase Cδ

Angela M. Ohm, Trisiani Affandi, Julie A. Reisz, M. Cecilia Caino, Angelo D’Alessandro, Mary E. Reyland

J Biol Chem. 2023 Oct; 299(10): 105186. Published online 2023 Aug 21. doi: 10.1016/j.jbc.2023.105186

PMCID:: PMC10519828

Abstract Article PDF–1.4M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102366388.

Inhibition of protein kinase C delta leads to cellular senescence to induce anti‐tumor effects in colorectal cancer

Yuya Shimoyama, Kohji Yamada, Saishu Yoshida, Akira Kawamura, Yoshito Hannya, Yuta Imaizumi, Tomotaka Kumamoto, Yasuhiro Takeda, Masayuki Shimoda, Ken Eto, Kiyotsugu Yoshida

Cancer Sci. 2023 Jun; 114(6): 2471–2484. Published online 2023 Mar 14. doi: 10.1111/cas.15768

PMCID:: PMC10236638

Abstract Article PDF–17M

Select item 100729069.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1005400710.

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator

Cláudia Bessa, Joana B. Loureiro, Matilde Barros, Vera M. S. Isca, Vilma A. Sardão, Paulo J. Oliveira, Raquel L. Bernardino, Carina Herman-de-Sousa, Maria Adelina Costa, Paulo Correia-de-Sá, Marco G. Alves, Patrícia Rijo, Lucília Saraiva

Int J Mol Sci. 2023 Mar; 24(6): 5710. Published online 2023 Mar 16. doi: 10.3390/ijms24065710

PMCID:: PMC10054007

Abstract Article PDF–2.8M

Select item 996523811.

Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation

Faik Imeri, Bisera Stepanovska Tanturovska, Roxana Manaila, Hermann Pavenstädt, Josef Pfeilschifter, Andrea Huwiler

Int J Mol Sci. 2023 Feb; 24(4): 3267. Published online 2023 Feb 7. doi: 10.3390/ijms24043267

PMCID:: PMC9965238

Abstract Article PDF–2.3M

Select item 992655112.

Genetic association of PRKCD and CARD9 polymorphisms with Vogt–Koyanagi–Harada disease in the Chinese Han population

Chunya Zhou, Shiya Cai, Yuhong Xie, Zhen Zeng, Jun Zhang, Guannan Su, Qiuying Wu, Xingsheng Ye, Qingfeng Cao, Peizeng Yang, Jianmin Hu

Hum Genomics. 2023; 17: 9. Published online 2023 Feb 13. doi: 10.1186/s40246-023-00459-7

PMCID:: PMC9926551

Abstract Article PDF–896K

Select item 976969813.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 947545314.

The N⁶-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2

Boyan Li, Rongrong Zhao, Wei Qiu, Ziwen Pan, Shulin Zhao, Yanhua Qi, Jiawei Qiu, Shouji Zhang, Qindong Guo, Yang Fan, Hao Xu, Ming Li, Gang Li, Hao Xue

Theranostics. 2022; 12(14): 6363–6379. Published online 2022 Aug 29. doi: 10.7150/thno.74600

PMCID:: PMC9475453

Abstract Article PDF–4.4M

Select item 927928515.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 927741116.

Extracellular PKCδ signals to epidermal growth factor receptor for tumor proliferation in liver cancer cells

Kohji Yamada, Ryusuke Kizawa, Ayano Yoshida, Rei Koizumi, Saya Motohashi, Yuya Shimoyama, Yoshito Hannya, Saishu Yoshida, Tsunekazu Oikawa, Masayuki Shimoda, Kiyotsugu Yoshida

Cancer Sci. 2022 Jul; 113(7): 2378–2385. Published online 2022 May 12. doi: 10.1111/cas.15386

PMCID:: PMC9277411

Abstract Article PDF–2.4M

Select item 911973617.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 905883618.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 889702219.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 881688420.

SGK2, 14-3-3 and HUWE1 cooperate to control the localization, stability and function of the oncoprotein PTOV1

Katie L. Pennington, Colten M. McEwan, James Woods, Colin Muir, A.G.P. Pramoda Sahankumari, Riley Eastmond, Eranga R. Balasooriya, Christina M. Egbert, Sandeep Kaur, Tyler Heaton, Katherine K. McCormack, Stephen R. Piccolo, Manabu Kurokawa, Joshua L. Andersen

Mol Cancer Res. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Mol Cancer Res. 2022 Feb; 20(2): 231–243. Published online 2021 Oct 15. doi: 10.1158/1541-7786.MCR-20-1076

PMCID:: PMC8816884

Abstract Article PDF–1.9M

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