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Select item 111599861.

Vacuolar H⁺‐ATPase inhibitors overcome Bcl‐xL‐mediated chemoresistance through restoration of a caspase‐independent apoptotic pathway

Yukiko Sasazawa, Yushi Futamura, Etsu Tashiro, Masaya Imoto

Cancer Sci. 2009 Aug; 100(8): 1460–1467. Published online 2009 Apr 21. doi: 10.1111/j.1349-7006.2009.01194.x

PMCID:: PMC11159986

Abstract Article PDF–2.0M

Select item 111590962.

Bcl‐X_L and STAT3 mediate malignant actions of γ‐irradiation in lung cancer cells

Jin‐Nyoung Ho, Ga Young Kang, Seung‐Sook Lee, Jongdoo Kim, In Hwa Bae, Sang‐Gu Hwang, Hong‐Duck Um

Cancer Sci. 2010 Jun; 101(6): 1417–1423. Published online 2010 Mar 4. doi: 10.1111/j.1349-7006.2010.01552.x

PMCID:: PMC11159096

Abstract Article PDF–721K

Select item 111418773.

OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma

Trang T.T. Nguyen, Consuelo Torrini, Enyuan Shang, Chang Shu, Jeong-Yeon Mun, Qiuqiang Gao, Nelson Humala, Hasan O. Akman, Guoan Zhang, Mike-Andrew Westhoff, Georg Karpel-Massler, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin

JCI Insight. 2024 Apr 22; 9(8): e172565. Published online 2024 Mar 14. doi: 10.1172/jci.insight.172565

PMCID:: PMC11141877

Abstract Article PDF–7.3M

Select item 110328214.

Mature dendritic cells are protected from Fas/CD95-mediated apoptosis by upregulation of Bcl-X_L

Andreas Lundqvist, Takako Nagata, Rolf Kiessling, Pavel Pisa

Cancer Immunol Immunother. 2002 May; 51(3): 139–144. Published online 2002 Mar 1. doi: 10.1007/s00262-002-0265-7

PMCID:: PMC11032821

Abstract Article PDF–128K

Select item 108819965.

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, Xiaohua Chen, Boyi Yu, Xiaogang Zhen, Jing Si, Chao Sun, Hong Zhang, Cuixia Di

Cell Death Dis. 2024 Feb; 15(2): 160. Published online 2024 Feb 21. doi: 10.1038/s41419-024-06507-x

PMCID:: PMC10881996

Abstract Article PDF–5.0M

Select item 108445236.

Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

Ling Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, Zhongming Zhao, Bisrat G Debeb, Xu Feng, Junjie Chen

Life Sci Alliance. 2024 Apr; 7(4): e202302353. Published online 2024 Feb 5. doi: 10.26508/lsa.202302353

PMCID:: PMC10844523

Abstract Article PDF–4.9M

Select item 107763847.

ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides

Claudia Cerella, Sruthi Reddy Gajulapalli, Anne Lorant, Deborah Gerard, Florian Muller, Yejin Lee, Kyung Rok Kim, Byung Woo Han, Christo Christov, Christian Récher, Jean-Emmanuel Sarry, Mario Dicato, Marc Diederich

Leukemia. 2024; 38(1): 67–81. Published online 2023 Oct 30. doi: 10.1038/s41375-023-02076-8

PMCID:: PMC10776384

Abstract Article PDF–4.1M

Select item 106390698.

Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA

Ronan Le Sénéchal, Marc Keruzoré, Alicia Quillévéré, Nadège Loaëc, Van-Trang Dinh, Oksana Reznichenko, Pedro Guixens-Gallardo, Laurent Corcos, Marie-Paule Teulade-Fichou, Anton Granzhan, Marc Blondel

Nucleic Acids Res. 2023 Nov 10; 51(20): 11239–11257. Published online 2023 Oct 9. doi: 10.1093/nar/gkad772

PMCID:: PMC10639069

Abstract Article PDF–2.4M

Select item 103644359.

Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment

Anna Maria Lucianò, Marta Di Martile, Ana B. Pérez-Oliva, Marica Di Caprio, Maria Laura Foddai, Simonetta Buglioni, Victoriano Mulero, Donatella Del Bufalo

J Exp Clin Cancer Res. 2023; 42: 178. Published online 2023 Jul 24. doi: 10.1186/s13046-023-02735-9

PMCID:: PMC10364435

Abstract Article PDF–4.4M

Select item 1031267410.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560

Published in:: Mol Syst Biol. 2024 Apr; 20(4): 428–457.

PMCID:: PMC10312674

Abstract Article PDF–9.6M

Select item 1020228111.

Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis

Lyndsey N. Moore, Daniel L. Holmes, Anjali Sharma, Joselyn Landazuri Vinueza, Michael Lagunoff

PLoS Pathog. 2023 May; 19(5): e1011385. Published online 2023 May 10. doi: 10.1371/journal.ppat.1011385

PMCID:: PMC10202281

Abstract Article PDF–1.9M

Select item 1017524512.

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

Ruifan Wu, Jooman Park, Yanyu Qian, Zuoxiao Shi, Ruoci Hu, Yexian Yuan, Shaolei Xiong, Zilai Wang, Gege Yan, Sang-Ging Ong, Qing Song, Zhenyuan Song, Abeer M. Mahmoud, Pingwen Xu, Congcong He, Robert W. Arpke, Michael Kyba, Gang Shu, Qingyan Jiang, Yuwei Jiang

Nat Commun. 2023; 14: 2731. Published online 2023 May 12. doi: 10.1038/s41467-023-38471-z

PMCID:: PMC10175245

Abstract Article PDF–6.7M

Select item 1005601513.

BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis

Atenea A. Perez-Serna, Reinaldo S. Dos Santos, Cristina Ripoll, Angel Nadal, Decio L. Eizirik, Laura Marroqui

Int J Mol Sci. 2023 Mar; 24(6): 5657. Published online 2023 Mar 16. doi: 10.3390/ijms24065657

PMCID:: PMC10056015

Abstract Article PDF–3.8M

Select item 989828814.

TPX2 prompts mitotic survival via the induction of BCL2L1 through YAP1 protein stabilization in human embryonic stem cells

Yun-Jeong Kim, Young-Hyun Go, Ho-Chang Jeong, Eun-Ji Kwon, Seong-Min Kim, Hyun Sub Cheong, Wantae Kim, Hyoung Doo Shin, Haeseung Lee, Hyuk-Jin Cha

Exp Mol Med. 2023 Jan; 55(1): 32–42. Published online 2023 Jan 4. doi: 10.1038/s12276-022-00907-9

PMCID:: PMC9898288

Abstract Article PDF–4.0M

Select item 976993715.

Ubiquitination of SARS-CoV-2 ORF7a Prevents Cell Death Induced by Recruiting BclXL To Activate ER Stress

Zhixin Liu, Yanan Fu, Yanping Huang, Feng Zeng, Jingjing Rao, Xiao Xiao, Xiaoguang Sun, Hao Jin, Jian Li, Jing Yang, Weixing Du, Long Liu

Microbiol Spectr. 2022 Nov-Dec; 10(6): e01509-22. Published online 2022 Nov 3. doi: 10.1128/spectrum.01509-22

Correction in:: Microbiol Spectr. 2024 Jan; 12(1): e03670-23.

PMCID:: PMC9769937

Abstract Article PDF–4.6M

Select item 969895716.

Bioinformatic Analysis of the BCL-xL/BCL2L1 Interactome in Patients with Pancreatic Cancer

Dimitrios E. Magouliotis, Anna P. Karamolegkou, Prokopis-Andreas Zotos, Evangelos Tatsios, Athina A. Samara, Dimitra Alexopoulou, Fani Koutsougianni, Nikos Sakellaridis, Dimitris Zacharoulis, Konstantinos Dimas

Medicina (Kaunas) 2022 Nov; 58(11): 1663. Published online 2022 Nov 17. doi: 10.3390/medicina58111663

PMCID:: PMC9698957

Abstract Article PDF–2.3M

Select item 945609217.

Aurora Kinase A and Bcl-xL Inhibition Suppresses Metastasis in Triple-Negative Breast Cancer

Natascha Skov, Carla L. Alves, Sidse Ehmsen, Henrik J. Ditzel

Int J Mol Sci. 2022 Sep; 23(17): 10053. Published online 2022 Sep 2. doi: 10.3390/ijms231710053

PMCID:: PMC9456092

Abstract Article PDF–4.6M

Select item 899001118.

Bcl-xL acts as an inhibitor of IP₃R channels, thereby antagonizing Ca²⁺-driven apoptosis

Nicolas Rosa, Hristina Ivanova, Larry E. Wagner, 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W. Andrews, Jan B. Parys, David I. Yule, Geert Bultynck

Cell Death Differ. 2022 Apr; 29(4): 788–805. Published online 2021 Nov 8. doi: 10.1038/s41418-021-00894-w