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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74470032.

The Human TSHβ Subunit Proteins and Their Binding Sites on the TSH Receptor Using Molecular Dynamics Simulation

Mihaly Mezei, Ramkumarie Baliram, M Rejwan Ali, Mone Zaidi, Terry F Davies, Rauf Latif

Endocrinology. 2020 Sep; 161(9): bqaa125. Published online 2020 Aug 1. doi: 10.1210/endocr/bqaa125

PMCID:: PMC7447003

Abstract Article

Select item 74141353.

GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

Wei Zhou, Ben Brumpton, Omer Kabil, Julius Gudmundsson, Gudmar Thorleifsson, Josh Weinstock, Matthew Zawistowski, Jonas B. Nielsen, Layal Chaker, Marco Medici, Alexander Teumer, Silvia Naitza, Serena Sanna, Ulla T. Schultheiss, Anne Cappola, Juha Karjalainen, Mitja Kurki, Morgan Oneka, Peter Taylor, Lars G. Fritsche, Sarah E. Graham, Brooke N. Wolford, William Overton, Humaira Rasheed, Eirin B. Haug, Maiken E. Gabrielsen, Anne Heidi Skogholt, Ida Surakka, George Davey Smith, Anita Pandit, Tanmoy Roychowdhury, Whitney E. Hornsby, Jon G. Jonasson, Leigha Senter, Sandya Liyanarachchi, Matthew D. Ringel, Li Xu, Lambertus A. Kiemeney, Huiling He, Romana T. Netea-Maier, Jose I. Mayordomo, Theo S. Plantinga, Jon Hrafnkelsson, Hannes Hjartarson, Erich M. Sturgis, Aarno Palotie, Mark Daly, Cintia E. Citterio, Peter Arvan, Chad M. Brummett, Michael Boehnke, Albert de la Chapelle, Kari Stefansson, Kristian Hveem, Cristen J. Willer, Bjørn Olav Åsvold

Nat Commun. 2020; 11: 3981. Published online 2020 Aug 7. doi: 10.1038/s41467-020-17718-z

Correction in:: Nat Commun. 2021; 12: 7354.

PMCID:: PMC7414135

Abstract Article PDF–1.1M

Select item 73082134.

Central congenital hypothyroidism caused by a novel mutation, C47W, in the cysteine knot region of TSHβ

Reham S. Ebrhim, Ryan J. Bruellman, Yui Watanabe, Matthew K. Creech, Mohamed A. Abdullah, Alexandra M. Dumitrescu, Samuel Refetoff, Roy E. Weiss

Horm Res Paediatr. Author manuscript; available in PMC 2020 Jun 23.

Published in final edited form as: Horm Res Paediatr. 2019; 92(6): 390–394. Published online 2020 Jan 8. doi: 10.1159/000504981

PMCID:: PMC7308213

Abstract Article PDF–803K

Select item 68883575.

The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR

Laura Kalveram, Gunnar Kleinau, Kamila Szymańska, Patrick Scheerer, Adolfo Rivero-Müller, Annette Grüters-Kieslich, Heike Biebermann

Int J Mol Sci. 2019 Nov; 20(22): 5564. Published online 2019 Nov 7. doi: 10.3390/ijms20225564

PMCID:: PMC6888357

Abstract Article PDF–7.3M

Select item 68214756.

A RECURRENT MUTATION IN TSHB GENE UNDERLYING CENTRAL CONGENITAL HYPOTHYROIDISM UNDETECTABLE IN NEONATAL SCREENING

Maria de Fátima Borges, Horacio Mario Domené, Paula Alejandra Scaglia, Beatriz Hallal Jorge Lara, Heloísa Marcelina da Cunha Palhares, Andréia Vasconcelos Aguiar Santos, Amanda Lacerda Ferreira Gonçalves, Marília Matos Oliveira, Alessandra Bernadete Trovó de Marqui

Rev Paul Pediatr. 2019 Oct-Dec; 37(4): 520–524. Published online 2019 Jun 3. doi: 10.1590/1984-0462/;2019;37;4;00017

PMCID:: PMC6821475

Abstract Article PDF–900K

Select item 65042137.

Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques

Chongbo Yang, Ming Lu, Wenbin Chen, Zhao He, Xu Hou, Mei Feng, Hongjia Zhang, Tao Bo, Xiaoming Zhou, Yong Yu, Haiqing Zhang, Meng Zhao, Laicheng Wang, Chunxiao Yu, Ling Gao, Wenjian Jiang, Qunye Zhang, Jiajun Zhao

J Exp Med. 2019 May 6; 216(5): 1182–1198. Published online 2019 Apr 2. doi: 10.1084/jem.20181473

Correction in:: J Exp Med. 2022 Feb 7; 219(2): jem.2018147312212021c.

PMCID:: PMC6504213

Abstract Article PDF–3.8M

Select item 56028968.

TSHB mRNA is linked to cholesterol metabolism in adipose tissue

José María Moreno-Navarrete, María Moreno, Francisco Ortega, Gemma Xifra, Shangyu Hong, John M. Asara, José C. E. Serrano, Mariona Jové, Pavlos Pissios, Matthias Blüher, Wifredo Ricart, Manuel Portero-Otin, José Manuel Fernández-Real

FASEB J. 2017 Oct; 31(10): 4482–4491. Published online 2017 Jun 23. doi: 10.1096/fj.201700161R

PMCID:: PMC5602896

Abstract Article

Select item 55968119.

Congenital Central Hypothyroidism Caused by a Novel Thyroid-Stimulating Hormone-Beta Subunit Gene Mutation in Two Siblings

Bayram Özhan, Özlem Boz Anlaş, Bilge Sarıkepe, Burcu Albuz, Nur Semerci Gündüz

J Clin Res Pediatr Endocrinol. 2017 Sep; 9(3): 278–282. Published online 2017 Sep 1. doi: 10.4274/jcrpe.4595

PMCID:: PMC5596811

Abstract Article PDF–816K

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 534699811.

Serum Macro TSH Level is Associated with Sleep Quality in Patients with Cardiovascular Risks – HSCAA Study

Manabu Kadoya, Sachie Koyama, Akiko Morimoto, Akio Miyoshi, Miki Kakutani, Kae Hamamoto, Masafumi Kurajoh, Takuhito Shoji, Yuji Moriwaki, Masahiro Koshiba, Tetsuya Yamamoto, Masaaki Inaba, Mitsuyoshi Namba, Hidenori Koyama

Sci Rep. 2017; 7: 44387. Published online 2017 Mar 13. doi: 10.1038/srep44387

PMCID:: PMC5346998

Abstract Article PDF–643K

Select item 522564812.

Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome

Lynnda J. N. van Tienhoven-Wind, Robin P. F. Dullaart

Lipids Health Dis. 2017; 16: 6. Published online 2017 Jan 11. doi: 10.1186/s12944-016-0403-4

PMCID:: PMC5225648

Abstract Article PDF–363K

Select item 500789213.

T₃ Regulates a Human Macrophage-Derived TSH-β Splice Variant: Implications for Human Bone Biology

R. Baliram, R. Latif, S. A. Morshed, M. Zaidi, T. F. Davies

Endocrinology. 2016 Sep; 157(9): 3658–3667. Published online 2016 Jun 20. doi: 10.1210/en.2015-1974

PMCID:: PMC5007892

Abstract Article

Select item 464794114.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012