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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102203882.

ATP13A2 activates the pentose phosphate pathway to promote colorectal cancer growth though TFEB‐PGD axis

Fan Zhang, Zhiwei Wu, Bowen Yu, Zhengping Ning, Zhixing Lu, Liang Li, Fei Long, Qionggui Hu, Chonglei Zhong, Yi Zhang, Changwei Lin

Clin Transl Med. 2023 May; 13(5): e1272. Published online 2023 May 26. doi: 10.1002/ctm2.1272

PMCID:: PMC10220388

Abstract Article PDF–8.4M

Select item 101191283.

Parkinson’s disease-associated ATP13A2/PARK9 functions as a lysosomal H⁺,K⁺-ATPase

Takuto Fujii, Shushi Nagamori, Pattama Wiriyasermkul, Shizhou Zheng, Asaka Yago, Takahiro Shimizu, Yoshiaki Tabuchi, Tomoyuki Okumura, Tsutomu Fujii, Hiroshi Takeshima, Hideki Sakai

Nat Commun. 2023; 14: 2174. Published online 2023 Apr 20. doi: 10.1038/s41467-023-37815-z

PMCID:: PMC10119128

Abstract Article PDF–1.6M

Select item 97077664.

ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway

Yuta Hatori, Yukina Kanda, Saori Nonaka, Hiroshi Nakanishi, Takeo Kitazawa

PLoS One. 2022; 17(11): e0276823. Published online 2022 Nov 29. doi: 10.1371/journal.pone.0276823

PMCID:: PMC9707766

Abstract Article PDF–2.0M

Select item 92626145.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 86157256.

Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson’s Disease Related Genes, PINK1 and PARK9

Anastasiia Bohush, Agnieszka Góral, Małgorzata Sierant, Barbara Nawrot, Wiesława Leśniak, Anna Filipek

Biomolecules. 2021 Nov; 11(11): 1675. Published online 2021 Nov 11. doi: 10.3390/biom11111675

PMCID:: PMC8615725

Abstract Article PDF–2.0M

Select item 86047757.

Structural basis of polyamine transport by human ATP13A2 (PARK9)

Sue Im Sim, Sören von Bülow, Gerhard Hummer, Eunyong Park

Mol Cell. Author manuscript; available in PMC 2022 Nov 18.

Published in final edited form as: Mol Cell. 2021 Nov 18; 81(22): 4635–4649.e8. Published online 2021 Oct 28. doi: 10.1016/j.molcel.2021.08.017

PMCID:: PMC8604775

Abstract Article PDF–4.2M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79621099.

ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization

Jianmin Si, Chris Van den Haute, Evy Lobbestael, Shaun Martin, Sarah van Veen, Peter Vangheluwe, Veerle Baekelandt

Int J Mol Sci. 2021 Mar; 22(5): 2689. Published online 2021 Mar 7. doi: 10.3390/ijms22052689

PMCID:: PMC7962109

Abstract Article PDF–4.8M

Select item 773381910.

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress

Stephanie Vrijsen, Laura Besora-Casals, Sarah van Veen, Jeffrey Zielich, Chris Van den Haute, Norin Nabil Hamouda, Christian Fischer, Bart Ghesquière, Ivailo Tournev, Patrizia Agostinis, Veerle Baekelandt, Jan Eggermont, Eric Lambie, Shaun Martin, Peter Vangheluwe

Proc Natl Acad Sci U S A. 2020 Dec 8; 117(49): 31198–31207. Published online 2020 Nov 23. doi: 10.1073/pnas.1922342117

PMCID:: PMC7733819

Abstract Article PDF–1.3M

Select item 772349211.

ATP13A2 Gene Variants in Patients with Parkinson's Disease in Xinjiang

Dan Wang, Hua Gao, Yanxia Li, Sen Jiang, Xinling Yang

Biomed Res Int. 2020; 2020: 6954820. Published online 2020 Nov 30. doi: 10.1155/2020/6954820

PMCID:: PMC7723492

Abstract Article PDF–351K

Select item 761244212.

Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2

Atsuhiro Tomita, Takashi Daiho, Tsukasa Kusakizako, Keitaro Yamashita, Satoshi Ogasawara, Takeshi Murata, Tomohiro Nishizawa, Osamu Nureki

Mol Cell. Author manuscript; available in PMC 2022 Feb 28.

Published in final edited form as: Mol Cell. 2021 Dec 2; 81(23): 4799–4809.e5. Published online 2021 Nov 18. doi: 10.1016/j.molcel.2021.11.001

PMCID:: PMC7612442

Abstract Article PDF–3.8M

Select item 715064913.

Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function

Nikhita Anand, Angelina Holcom, Michael Broussalian, Minna Schmidt, Shankar J. Chinta, Gordon J. Lithgow, Julie K. Andersen, Manish Chamoli

Neurobiol Dis. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Neurobiol Dis. 2020 Jun; 139: 104786. Published online 2020 Feb 5. doi: 10.1016/j.nbd.2020.104786

PMCID:: PMC7150649

Abstract Article PDF–1.2M

Select item 705708114.

Clinical and genetic analysis of ATP13A2 in hereditary spastic paraplegia expands the phenotype

Mehrdad A. Estiar, Etienne Leveille, Dan Spiegelman, Nicolas Dupre, Jean-François Trempe, Guy A. Rouleau, Ziv Gan‐Or

Mol Genet Genomic Med. 2020 Mar; 8(3): e1052. Published online 2020 Jan 15. doi: 10.1002/mgg3.1052

PMCID:: PMC7057081

Abstract Article PDF–764K

Select item 700124515.

Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson’s disease in Black South African and Nigerian patients

Oluwafemi G. Oluwole, Helena Kuivaniemi, Shameemah Abrahams, William L. Haylett, Alvera A. Vorster, Carel J. van Heerden, Colin P. Kenyon, David L. Tabb, Michael B. Fawale, Taofiki A. Sunmonu, Abiodun Ajose, Matthew O. Olaogun, Anastasia C. Rossouw, Ludo S. van Hillegondsberg, Jonathan Carr, Owen A. Ross, Morenikeji A. Komolafe, Gerard Tromp, Soraya Bardien

BMC Med Genet. 2020; 21: 23. Published online 2020 Feb 4. doi: 10.1186/s12881-020-0953-1

PMCID:: PMC7001245

Abstract Article PDF–1.2M

Select item 668728116.

Overexpression of human Atp13a2^Isoform-1 protein protects cells against manganese and starvation-induced toxicity

Janet Ugolino, Kristina M. Dziki, Annette Kim, Josephine J. Wu, Bruce E. Vogel, Mervyn J. Monteiro

PLoS One. 2019; 14(8): e0220849. Published online 2019 Aug 8. doi: 10.1371/journal.pone.0220849

PMCID:: PMC6687281

Abstract Article PDF–2.5M

Select item 649360417.

ATP13A2 Knockout Does not Affect the Infarct Size in Mice with Acute Ischemic Stroke

Jian‐Guang Yu, Mei‐Jian Cui, Wei Wang, Kai‐Bing Hu, Guo‐Jun Cai

CNS Neurosci Ther. 2012 Dec; 18(12): 1027–1029. Published online 2012 Nov 3. doi: 10.1111/cns.12023

PMCID:: PMC6493604

Article PDF–153K

Select item 646910218.

Mutations in ATP13A2 (PARK9) are associated with an amyotrophic lateral sclerosis-like phenotype, implicating this locus in further phenotypic expansion

Rossella Spataro, Maria Kousi, Sali M. K. Farhan, Jason R. Willer, Jay P. Ross, Patrick A. Dion, Guy A. Rouleau, Mark J. Daly, Benjamin M. Neale, Vincenzo La Bella, Nicholas Katsanis

Hum Genomics. 2019; 13: 19. Published online 2019 Apr 16. doi: 10.1186/s40246-019-0203-9

PMCID:: PMC6469102

Abstract Article PDF–1.8M

Select item 640428219.

Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

Subramanian Rajagopalan, Anand Rane, Shankar J. Chinta, Julie K. Andersen

J Neurosci. 2016 Jan 27; 36(4): 1086–1095. doi: 10.1523/JNEUROSCI.3117-15.2016

PMCID:: PMC6404282

Abstract Article PDF–2.7M

Select item 631455220.

ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion

Ruoxi Wang, Jieqiong Tan, Tingting Chen, Hailong Han, Runyi Tian, Ya Tan, Yiming Wu, Jingyi Cui, Fang Chen, Jie Li, Lu Lv, Xinjie Guan, Shuai Shang, Jiahong Lu, Zhuohua Zhang

J Cell Biol. 2019 Jan 7; 218(1): 267–284. doi: 10.1083/jcb.201804165

PMCID:: PMC6314552

Abstract Article PDF–5.0M

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PMC Links for GEO Profiles (Select 132503994) (64)
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Chryseobacterium ginsengisoli strain JCM 18019 sequence25, whole genome shotgun ...
Chryseobacterium ginsengisoli strain JCM 18019 sequence25, whole genome shotgun sequence
gi|2731099954|ref|NZ_BAABHX01000002 gnl|WGS:NZ_BAABHX01|sequence25

Nucleotide
Homo sapiens parkin RBR E3 ubiquitin protein ligase (PRKN), RefSeqGene on chromo...
Homo sapiens parkin RBR E3 ubiquitin protein ligase (PRKN), RefSeqGene on chromosome 6
gi|1151359166|ref|NG_008289.2|

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