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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 108832802.

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

Chop Yan Lee, Dalmira Hubrich, Julia K Varga, Christian Schäfer, Mareen Welzel, Eric Schumbera, Milena Djokic, Joelle M Strom, Jonas Schönfeld, Johanna L Geist, Feyza Polat, Toby J Gibson, Claudia Isabelle Keller Valsecchi, Manjeet Kumar, Ora Schueler-Furman, Katja Luck

Mol Syst Biol. 2024 Feb; 20(2): 75–97. Published online 2024 Jan 15. doi: 10.1038/s44320-023-00005-6

PMCID:: PMC10883280

Abstract Article PDF–3.4M

Select item 105658763.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 100091014.

TRIM37 interacts with PTEN to promote the growth of human T-cell acute lymphocytic leukemia cells through regulating PI3K/AKT pathway

Honglan Qu, HASEN Gao-wa, Yanyan Hou, Mengwei Ren, Jun Li, Baoshong Jing, YanDan Du

Front Oncol. 2022; 12: 1016725. Published online 2023 Feb 27. doi: 10.3389/fonc.2022.1016725

PMCID:: PMC10009101

Abstract Article PDF–7.4M

Select item 96333025.

Metformin inhibits the proliferation and invasion of ovarian cancer cells by suppressing tripartite motif‐containing 37‐induced tumor necrosis factor receptor‐associated factor 2 ubiquitination

Ya Zheng, Haiyan Zhang, Hong Sun

Cancer Sci. 2022 Nov; 113(11): 3776–3786. Published online 2022 Sep 3. doi: 10.1111/cas.15524

PMCID:: PMC9633302

Abstract Article PDF–5.1M

Select item 95454726.

Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism)

Johanna Sivunen, Susann Karlberg, Reetta Kivisaari, Jouko Lohi, Niklas Karlberg, Eero Jokinen, Taisto Sarkola, Timo Jahnukainen, Marita Lipsanen‐Nyman, Hannu Jalanko

Liver Int. 2022 Jun; 42(6): 1369–1378. Published online 2022 Mar 8. doi: 10.1111/liv.15213

PMCID:: PMC9545472

Abstract Article PDF–740K

Select item 93485767.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92950748.

TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression

Guimei Cui, Zhuoran Gao, Shiehong Chang, Nitin Narwade, Yitian Chen, Barun Poudel, Kate M. K. Lei, Weibo Zhang, Gang Li, Terence C. W. Poon, Edwin Cheung

Int J Biol Sci. 2022; 18(11): 4316–4328. Published online 2022 Jul 4. doi: 10.7150/ijbs.69466

PMCID:: PMC9295074

Abstract Article PDF–2.7M

Select item 91052359.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 893022910.

Modified Yuejuwan Inhibited Cholesterol Accumulation and Inflammation in THP-1 Macrophage-Derived Foam Cells by Inhibiting the Activity of the TRIM37/TRAF2/NF-κB Pathway

Mingtai Gui, Lei Yao, Bo Lu, Jianhua Li, Jing Wang, Xunjie Zhou, Deyu Fu

Evid Based Complement Alternat Med. 2022; 2022: 6400517. Published online 2022 Mar 10. doi: 10.1155/2022/6400517

PMCID:: PMC8930229

Abstract Article PDF–1.1M

Select item 883566911.

TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment

Tuyen Thi Do, Chun-Chieh Yeh, Guo-Wei Wu, Chia-Chen Hsu, Hung-Chih Chang, Hui-Chen Chen

Int J Mol Sci. 2022 Feb; 23(3): 1176. Published online 2022 Jan 21. doi: 10.3390/ijms23031176

PMCID:: PMC8835669

Abstract Article PDF–5.9M

Select item 848772112.

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase

Shuai Zhao, Wafik S. El-Deiry

Oncotarget. 2021 Sep 28; 12(20): 1970–1979. Published online 2021 Sep 28. doi: 10.18632/oncotarget.28081

PMCID:: PMC8487721

Abstract Article PDF–3.1M

Select item 820444413.

TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner

Chenkui Miao, Chao Liang, Pu Li, Bianjiang Liu, Chao Qin, Han Yuan, Yiyang Liu, Jundong Zhu, Yankang Cui, Aiming Xu, Shangqian Wang, Shifeng Su, Jie Li, Pengfei Shao, Zengjun Wang

J Exp Clin Cancer Res. 2021; 40: 195. Published online 2021 Jun 15. doi: 10.1186/s13046-021-01980-0

PMCID:: PMC8204444

Abstract Article PDF–4.9M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812700615.

TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity

Franz Meitinger, Dong Kong, Midori Ohta, Arshad Desai, Karen Oegema, Jadranka Loncarek

J Cell Biol. 2021 Jul 5; 220(7): e202010180. Published online 2021 May 13. doi: 10.1083/jcb.202010180

PMCID:: PMC8127006

Abstract Article PDF–9.3M

Select item 787014116.

TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

Fernando R Balestra, Andrés Domínguez-Calvo, Benita Wolf, Coralie Busso, Alizée Buff, Tessa Averink, Marita Lipsanen-Nyman, Pablo Huertas, Rosa M Ríos, Pierre Gönczy

eLife. 2021; 10: e62640. Published online 2021 Jan 25. doi: 10.7554/eLife.62640

PMCID:: PMC7870141

Abstract Article PDF–4.8M

Select item 784067717.

Knockdown of Tripartite Motif-Containing Protein 37 (TRIM37) Inhibits the Proliferation and Tumorigenesis in Colorectal Cancer Cells

Ping Zhao, Hai-Tao Guan, Zhi-Jun Dai, Yu-Guang Ma, Xiao-Xu Liu, Xi-Jing Wang

Oncol Res. 2017; 25(1): 115–122. Published online 2017 Jan 2. doi: 10.3727/096504016X14732772150181

PMCID:: PMC7840677

Abstract Article PDF–6.1M

Select item 773189718.

Oncogenic TRIM37 links chemoresistance and metastatic fate in triple-negative breast cancer

Piotr Przanowski, Song Lou, Rachisan Djiake Tihagam, Tanmoy Mondal, Caroline Conlan, Gururaj Shivange, Ilyas Saltani, Chandrajeet Singh, Kun Xing, Benjamin B. Morris, Marty W. Mayo, Luis Teixeira, Jacqueline Lehmann-Che, Jogender Tushir-Singh, Sanchita Bhatnagar

Cancer Res. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Cancer Res. 2020 Nov 1; 80(21): 4791–4804. Published online 2020 Aug 27. doi: 10.1158/0008-5472.CAN-20-1459

PMCID:: PMC7731897

Abstract Article PDF–2.6M

Select item 765186219.

TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway

Shiyu Chen, Zhiwei He, Changhao Zhu, Yanqing Liu, Lin Li, Lu Deng, Jun Wang, Chao Yu, Chengyi Sun

Front Oncol. 2020; 10: 554787. Published online 2020 Oct 16. doi: 10.3389/fonc.2020.554787

PMCID:: PMC7651862

Abstract Article PDF–5.4M

Select item 759736720.

Exploiting TRIM37-driven centrosome dysfunction to kill breast cancer cells

Zhong Y. Yeow, Bramwell G. Lambrus, Rebecca Marlow, Kevin H. Zhan, Mary-Anne Durin, Lauren T. Evans, Phillip M. Scott, Thao Phan, Elizabeth Park, Lorena A. Ruiz, Daniela Moralli, Eleanor G. Knight, Luned M. Badder, Daniela Novo, Syed Haider, Catherine M. Green, Andrew NJ Tutt, Christopher J Lord, J. Ross Chapman, Andrew J. Holland

Nature. Author manuscript; available in PMC 2021 Sep 9.

Published in final edited form as: Nature. 2020 Sep; 585(7825): 447–452. Published online 2020 Sep 9. doi: 10.1038/s41586-020-2690-1

PMCID:: PMC7597367

Abstract Article PDF–1.7M

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