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Select item 108497651.

AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments

Wenrui Zhang, Lu Cao, Jian Yang, Shuai Zhang, Jianyi Zhao, Zhonggang Shi, Keman Liao, Haiwei Wang, Binghong Chen, Zhongrun Qian, Haoping Xu, Linshi Wu, Hua Liu, Hongxiang Wang, Chunhui Ma, Yongming Qiu, Jianwei Ge, Jiayi Chen, Yingying Lin

J Clin Invest. 2024 Feb 1; 134(3): e173299. Published online 2024 Feb 1. doi: 10.1172/JCI173299

PMCID:: PMC10849765

Abstract Article PDF–24M

Select item 107112232.

c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6

Yanli Jiang, Longfei Li, Ruozhen Wu, Liulin Wu, Bin Zhang, Jian-Zhi Wang, Rong Liu, Fei Liu, Jing Wang, Xiaochuan Wang

J Biol Chem. 2023 Dec; 299(12): 105462. Published online 2023 Nov 15. doi: 10.1016/j.jbc.2023.105462

PMCID:: PMC10711223

Abstract Article PDF–2.9M

Select item 105933883.

Relação entre Níveis Plasmáticos Aumentados de Legumain e Propriedades da Placa Aterosclerótica Coronária

Yunpeng Deng, Yudong Fan, Di Wu, Zilong Zhang, Miaomiao Zhang, Zhiping Huang, Yuxia Gao

Arq Bras Cardiol. 2023 Nov; 120(11): e20230395. Portuguese. Published online 2023 Oct 23. doi: 10.36660/abc.20230395

PMCID:: PMC10593388

Abstract Article PDF–822K

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99412375.

Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer

Xiaojing Xu, Mengling Liu, Ke Peng, Yiyi Yu, Tianshu Liu

Clin Transl Oncol. 2023; 25(3): 776–785. Published online 2023 Jan 7. doi: 10.1007/s12094-022-02986-6

PMCID:: PMC9941237

Abstract Article PDF–1.6M

Select item 98160596.

CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1

Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou

Oncogene. 2023; 42(2): 83–98. Published online 2022 Nov 12. doi: 10.1038/s41388-022-02537-x

PMCID:: PMC9816059

Abstract Article PDF–7.6M

Select item 92468687.

An infection-induced oxidation site regulates legumain processing and tumor growth

Yekaterina Kovalyova, Daniel W. Bak, Elizabeth M. Gordon, Connie Fung, Jennifer H. B. Shuman, Timothy L. Cover, Manuel R. Amieva, Eranthie Weerapana, Stavroula K. Hatzios

Nat Chem Biol. Author manuscript; available in PMC 2022 Sep 24.

Published in final edited form as: Nat Chem Biol. 2022 Jul; 18(7): 698–705. Published online 2022 Mar 24. doi: 10.1038/s41589-022-00992-x

PMCID:: PMC9246868

Abstract Article PDF–3.2M

Select item 92316238.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910523510.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 895155611.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 877399912.

Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene

Ada-Sophia Clees, Verena Stolp, Björn Häupl, Dominik C. Fuhrmann, Frank Wempe, Marcel Seibert, Sarah Weber, Antje Banning, Ritva Tikkanen, Richard Williams, Bernhard Brüne, Hubert Serve, Frank Schnütgen, Ivana von Metzler, Nina Kurrle

Cells. 2022 Jan; 11(2): 292. Published online 2022 Jan 15. doi: 10.3390/cells11020292

PMCID:: PMC8773999

Abstract Article PDF–4.9M

Select item 836418113.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 813982615.

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction

Xingyu Zhang, Li Zou, Lanxia Meng, Min Xiong, Lina Pan, Guiqin Chen, Yongfa Zheng, Jing Xiong, Zhihao Wang, Duc M Duong, Zhaohui Zhang, Xuebing Cao, Tao Wang, Li Tang, Keqiang Ye, Zhentao Zhang

eLife. 2021; 10: e65301. Published online 2021 May 21. doi: 10.7554/eLife.65301

PMCID:: PMC8139826

Abstract Article PDF–8.4M

Select item 784241316.

Knockdown of Legumain Suppresses Cervical Cancer Cell Migration and Invasion

Fei Meng, Wei Liu

Oncol Res. 2016; 23(1-2): 7–12. Published online 2016 Jan 21. doi: 10.3727/096504015X14410238486649

PMCID:: PMC7842413

Abstract Article PDF–25M

Select item 761477917.

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

Pablo Rodríguez-Silvestre, Marco Laub, Patrycja A. Krawczyk, Alexandra K. Davies, Julia P. Schessner, Reejuana Parveen, Benjamin J. Tuck, William A. McEwan, Georg H.H. Borner, Patrycja Kozik

Science. Author manuscript; available in PMC 2023 Jul 19.

Published in final edited form as: Science. 2023 Jun 23; 380(6651): 1258–1265. Published online 2023 Jun 22. doi: 10.1126/science.adg8802

PMCID:: PMC7614779

Abstract Article PDF–1.8M

Select item 742732718.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 739249119.

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination

Gangliang Wang, Shuai Chen, Ziang Xie, Shuying Shen, Wenbin Xu, Wenxiang Chen, Xiang Li, Yizheng Wu, Liangping Li, Bin Liu, Xianjun Ding, An Qin, Shunwu Fan

Ann Rheum Dis. 2020 Aug; 79(8): 1111–1120. Published online 2020 May 14. doi: 10.1136/annrheumdis-2019-216911

PMCID:: PMC7392491

Abstract Article PDF–14M

Select item 715693920.

Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma

Yingying Lin, Keman Liao, Yifeng Miao, Zhongrun Qian, Zhaoyuan Fang, Xi Yang, Quanmin Nie, Gan Jiang, Jianhua Liu, Yiyi Yu, Jieqing Wan, Xiaohua Zhang, Yaomin Hu, Jiyao Jiang, Yongming Qiu

J Natl Cancer Inst. 2020 Apr; 112(4): 343–355. Published online 2019 Jul 27. doi: 10.1093/jnci/djz155

PMCID:: PMC7156939

Abstract Article PDF–2.0M

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Tobacco smoke effect on maternal and fetal cells
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